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ChEMBL ligand: CHEMBL770 (NSC-35110, Priscoline, Tolazine, Tolazoline) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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5-HT1B receptor/Serotonin 1b (5-HT1b) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1898] [GtoPdb: 2] [UniProtKB: P28222] | ||||||||
ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1B receptor using [3H]5-HT trifluoroacetate as radioligand | B | 5 | pKi | >10000 | nM | Ki | J. Med. Chem. (1998) 41: 2243-2251 [PMID:9632357] |
ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1B receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg. Med. Chem. Lett. (2004) 14: 4697-4699 [PMID:15324890] |
5-HT1D receptor/Serotonin 1d (5-HT1d) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1983] [GtoPdb: 3] [UniProtKB: P28221] | ||||||||
ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1D receptor using [3H]5-HT trifluoroacetate as radioligand | B | 5 | pKi | >10000 | nM | Ki | J. Med. Chem. (1998) 41: 2243-2251 [PMID:9632357] |
ChEMBL | Binding affinity towards human 5-hydroxytryptamine 1D receptor | B | 5 | pKi | >10000 | nM | Ki | Bioorg. Med. Chem. Lett. (2004) 14: 4697-4699 [PMID:15324890] |
TA1 receptor/Trace amine-associated receptor 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5857] [GtoPdb: 364] [UniProtKB: Q96RJ0] | ||||||||
ChEMBL | Displacement of (S)-4-(2,4-difluorophenyl-3-tritio) -4,5-dihydro-2-oxazolamine from human TAAR1 receptor expressed in HEK293 cells after 90 mins by beta counting analysis | B | 5.79 | pKi | 1640 | nM | Ki | Bioorg. Med. Chem. Lett. (2012) 22: 5244-5248 [PMID:22795332] |
α2A-adrenoceptor in Human [GtoPdb: 25] [UniProtKB: P08913] | ||||||||
GtoPdb | Inhibition of agonist-stimulated [35S]GTPγS binding | - | 6.7 | pKi | 199 | nM | Ki | Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427] |
α2B-adrenoceptor in Human [GtoPdb: 26] [UniProtKB: P18089] | ||||||||
GtoPdb | Inhibition of agonist-stimulated [35S]GTPγS binding | - | 5.5 | pKi | 3162 | nM | Ki | Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427] |
α2C-adrenoceptor in Human [GtoPdb: 27] [UniProtKB: P18825] | ||||||||
GtoPdb | Inhibition of agonist-stimulated [35S]GTPγS binding | - | 5.43 | pKi | 3715 | nM | Ki | Biochem Pharmacol (1998) 55: 1035-43 [PMID:9605427] |
ChEMBL data shown on this page come from version 31:
Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]