MONNA [Ligand Id: 12258] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4086165 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| CaCC/Anoctamin-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2046267] [GtoPdb: 708] [UniProtKB: Q5XXA6] | ||||||||
| ChEMBL | Inhibition of human TMEM16A expressed in FRT cells assessed as reduction of ATP-induced in chloride conductance preincubated for 5 mins followed by ATP addition by short-circuit current assay | B | 5.8 | pIC50 | 1600 | nM | IC50 | J Med Chem (2017) 60: 4626-4635 [PMID:28493701] |
| ChEMBL | Inhibition of TMEM16A (unknown origin) expressed in Xenopus laevis oocytes at -60 mV holding potential by voltage-clamp assay | B | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2017) 60: 4626-4635 [PMID:28493701] |
| GtoPdb | Inhibition of TMEM16A current in Xenopus laevis oocytes by voltage-clamp assay. | - | 7.1 | pIC50 | 80 | nM | IC50 | J Med Chem (2017) 60: 4626-4635 [PMID:28493701] |
| Anoctamin-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4105767] [UniProtKB: Q9NQ90] | ||||||||
| ChEMBL | Inhibition of human TMEM16B expressed in FRT cells co-expressing iodide sensitive fluorescent protein YFP-H148Q/I152L/F46L assessed as reduction in ATP-induced Ca2+ activation-mediated chloride current by measuring decrease in iodide influx preincubated for 10 mins followed by ATP/iodide addition by fluorescence assay | B | 4.89 | pIC50 | 13000 | nM | IC50 | J Med Chem (2017) 60: 4626-4635 [PMID:28493701] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
