tetroxoprim [Ligand Id: 12328] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL32039 (Tetroxoprim, Tetroxoprima, Tetroxoprime) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Dihydrofolate reductase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1809] [UniProtKB: P0ABQ4] | ||||||||
| ChEMBL | Inhibition constant against binding of Escherichia coli dihydrofolate reductase | B | 8.35 | pKi | 4.47 | nM | Ki | J Med Chem (1988) 31: 1396-1406 [PMID:3290487] |
| ChEMBL | Inhibitory activity against Dihydrofolate reductase of Escherichia coli | B | 7.74 | pIC50 | 18 | nM | IC50 | J Med Chem (1981) 24: 933-941 [PMID:7035668] |
| Dihydrofolate reductase in Lactobacillus casei (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2902] [UniProtKB: P00381] | ||||||||
| ChEMBL | Inhibitory activity against Lactobacillus casei dihydrofolate reductase | B | 6.26 | pKi | 549.54 | nM | Ki | J Med Chem (1989) 32: 1895-1905 [PMID:2502631] |
| Dihydrofolate reductase in Pneumocystis carinii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1926] [UniProtKB: P16184] | ||||||||
| ChEMBL | Inhibitory activity against dihydrofolate reductase in Pneumocystis carinii at 37 centigrade. | B | 4.2 | pIC50 | >63000 | nM | IC50 | J Med Chem (1995) 38: 4739-4759 [PMID:7490723] |
| Dihydrofolate reductase in Salmonella enterica subsp. enterica serovar Typhi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4888] [UniProtKB: Q8Z9J9] | ||||||||
| ChEMBL | Inhibitory activity against Escherichia coli dihydrofolate reductase | B | 8.35 | pKi | 4.47 | nM | Ki | J Med Chem (1991) 34: 46-54 [PMID:1899453] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
