ChEMBL ligand: CHEMBL412262 (BMS-646256, Ibipinabant, Slv319, SLV-319)
CB1 receptor/Cannabinoid CB1 receptor in Human [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554] There should be some charts here, you may need to enable JavaScript!
CB2 receptor/Cannabinoid CB2 receptor in Human [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CB1 receptor/Cannabinoid CB1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL218] [GtoPdb: 56] [UniProtKB: P21554]
ChEMBL	Antagonistic activity towards cannabinoid receptor 1 expressed as [3H]Arachidonic acid release in CHO cells	F	9.9	pKd	0.13	nM	Kd	J Med Chem (2004) 47: 627-643 [PMID:14736243]
ChEMBL	Antagonistic activity against cannabinoid receptor 1 measured by CP-55940 induced arachnoid acid release in CHO cells	F	9.9	pKd	0.13	nM	Kd	Bioorg Med Chem Lett (2005) 15: 4794-4798 [PMID:16140010]
ChEMBL	Antagonist activity at human cannabinoid CB1 receptor expressed in CHO cells assessed as inhibition of CP-55940-induced [3H]arachidonic acid release	F	9.9	pKd	0.13	nM	Kd	Bioorg Med Chem Lett (2010) 20: 1752-1757 [PMID:20137935]
ChEMBL	Displacement of [3H]CP-55940 from human CB1R expressed in HEK293 cells	B	8.1	pKi	8	nM	Ki	J Med Chem (2008) 51: 2115-2127 [PMID:18335976]
ChEMBL	Displacement of specific CP-55940 binding in CHO cells stably transfected with human cannabinoid receptor 1	B	8.11	pKi	7.8	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4794-4798 [PMID:16140010]
ChEMBL	Displacement of CP-55940 binding from recombinant human cannabinoid receptor 1 expressed in CHO cells	B	8.11	pKi	7.8	nM	Ki	J Med Chem (2004) 47: 627-643 [PMID:14736243]
ChEMBL	Binding affinity to CB1 receptor	B	8.11	pKi	7.8	nM	Ki	J Med Chem (2008) 51: 2439-2446 [PMID:18363352]
ChEMBL	Displacement of [3H]rimonabant from human CB1 receptor expressed in HEK293 cells by liquid scintillation counting	B	8.11	pKi	7.8	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4183-4190 [PMID:19520572]
ChEMBL	Displacement of [3H]CP-55940 from human cannabinoid CB1 receptor expressed in CHO cells	B	8.11	pKi	7.8	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1752-1757 [PMID:20137935]
GtoPdb	Displacement of CP-55940 binding from recombinant human cannabinoid receptor 1 expressed in CHO cells	-	8.11	pKi	7.8	nM	Ki	J Med Chem (2004) 47: 627-43 [PMID:14736243]
ChEMBL	Displacement of radioligand from human CB1 receptor expressed in HEK293 cells	B	8.39	pKi	4.1	nM	Ki	Bioorg Med Chem Lett (2008) 18: 1199-1206 [PMID:18083560]
ChEMBL	Displacement of [3H]SR141716 from human recombinant CB1 receptor expressed in HEK293 cells	B	8.5	pKi	3.16	nM	Ki	J Med Chem (2009) 52: 1975-1982 [PMID:19338356]
ChEMBL	Displacement of [3H]BMS-725519 from human CB1 receptor expressed in CHO cells after 90 mins by scintillation counting	B	9.38	pKi	0.42	nM	Ki	Bioorg Med Chem Lett (2011) 21: 6856-6860 [PMID:21962575]
ChEMBL	Inverse agonist activity at CB1 receptor assessed as repression of basal receptor activity by mammalian cell-based receptor selection and amplification technology method	F	7.7	pIC50	19.95	nM	IC50	J Med Chem (2009) 52: 1975-1982 [PMID:19338356]
ChEMBL	Inhibition of [3H]CP-55940 binding to human recombinant CB1 receptor in CHO cells	B	7.77	pIC50	17	nM	IC50	J Med Chem (2006) 49: 7584-7587 [PMID:17181138]
CB2 receptor/Cannabinoid CB2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL253] [GtoPdb: 57] [UniProtKB: P34972]
GtoPdb	Displacement of specific CP-55,940 binding in CHO cells stably transfected with human CB2 receptor	-	5.1	pKi	7943	nM	Ki	J Med Chem (2004) 47: 627-43 [PMID:14736243]
ChEMBL	Affinity to displace CP-55940 binding from Cannabinoid receptor 2 of human expressed in CHO cells	B	5.1	pKi	7943	nM	Ki	J Med Chem (2004) 47: 627-643 [PMID:14736243]
ChEMBL	Binding affinity to CB2 receptor	B	5.1	pKi	7943	nM	Ki	J Med Chem (2008) 51: 2439-2446 [PMID:18363352]
ChEMBL	Displacement of [3H]rimonabant from human CB2 receptor expressed in HEK293 cells by liquid scintillation counting	B	5.1	pKi	7943	nM	Ki	Bioorg Med Chem Lett (2009) 19: 4183-4190 [PMID:19520572]
ChEMBL	Displacement of [3H]CP-55940 from human cannabinoid CB2 receptor expressed in CHO cells	B	5.1	pKi	7943	nM	Ki	Bioorg Med Chem Lett (2010) 20: 1752-1757 [PMID:20137935]
ChEMBL	Displacement of specific CP-55940 binding in CHO cells stably transfected with human cannabinoid receptor 2	B	5.13	pKi	7493	nM	Ki	Bioorg Med Chem Lett (2005) 15: 4794-4798 [PMID:16140010]
ChEMBL	Displacement of [3H]SR141716 from human recombinant CB2 receptor expressed in HEK293 cells	B	5.7	pKi	1995.26	nM	Ki	J Med Chem (2009) 52: 1975-1982 [PMID:19338356]
ChEMBL	Inhibition of [3H]CP-55940 binding to human recombinant CB2 receptor in CHO cells	B	5.96	pIC50	1100	nM	IC50	J Med Chem (2006) 49: 7584-7587 [PMID:17181138]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]