metronidazole [Ligand Id: 10914] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL137 (RP-8823, RP 8823, Flagyl compak, Protostat, Flagyl I.V. Rtu In Plastic Container, Zyomet, Flagyl 375, BAY-5360, Anabact, BAYER-5360, Rozex, BAYER 5360, Metrolyl, Satric, Vaginyl, Rosiced, NSC-69587, Drazifon, Metric 21, Acea, Metro i.v., Metromidol, Zidoval, Metrogel, Elyzol, Metrotop, Noritate, Metrocream, NSC-50364, Nuvessa, Flagyl-s, Norzol, Metrogel-vaginal, Vandazole, Zadstat, Metronidazole, Flagyl, Metrosa, Metrolotion, Neutratop, Flagyl er, Flagyl-400)
  • Plasmodium berghei [ChEMBL: CHEMBL612653]
  • This target only has 0 pki data point
  • 0
1 CHEMBL137_lig_chart_1 Plasmodium berghei Plasmodium berghei
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  • Thioredoxin reductase in Entamoeba histolytica [ChEMBL: CHEMBL3879846] [UniProtKB: C4LW95]
  • This target only has 1 pki data point
  • 5.48
2 CHEMBL137_lig_chart_2 Thioredoxin reductase Entamoeba histolytica
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653]
ChEMBL Antimalarial activity against Plasmodium berghei schizonts isolated from parasitized erythrocytes infected Wistar rat measured 16 hrs post compound exposure F 4.3 pIC50 >50000 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 3168-3171 [PMID:21397502]
Thioredoxin reductase in Entamoeba histolytica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879846] [UniProtKB: C4LW95]
ChEMBL Inhibition of Entamoeba histolytica thioredoxin reductase B 5.48 pKi 3300 nM Ki Eur J Med Chem (2016) 124: 393-406 [PMID:27597415]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]