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ChEMBL ligand: CHEMBL137 (Acea, Anabact, BAY-5360, BAYER 5360, BAYER-5360, Deflamon, Drazifon, Elyzol, Flagyl, Flagyl 375, Flagyl-400, Flagyl compak, Flagyl er, Flagyl I.V. Rtu In Plastic Container, Flagyl-s, Gineflavir, Metric 21, Metrocream, Metrogel, Metrogel-vaginal, Metro i.v., Metrolotion, Metrolyl, Metromidol, Metronidazole, Metrosa, Metrotop, Neutratop, Noritate, Norzol, NSC-50364, NSC-69587, Nuvessa, Orvagil, Protostat, Rosiced, Rozex, RP 8823, RP-8823, Satric, Vaginyl, Vandazole, Zadstat, Zidoval, Zyomet) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Plasmodium berghei (target type: ORGANISM) [ChEMBL: CHEMBL612653] | ||||||||
ChEMBL | Antimalarial activity against Plasmodium berghei schizonts isolated from parasitized erythrocytes infected Wistar rat measured 16 hrs post compound exposure | F | 4.3 | pIC50 | >50000 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 3168-3171 [PMID:21397502] |
Thioredoxin reductase in Entamoeba histolytica (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3879846] [UniProtKB: C4LW95] | ||||||||
ChEMBL | Inhibition of Entamoeba histolytica thioredoxin reductase | B | 5.48 | pKi | 3300 | nM | Ki | Eur J Med Chem (2016) 124: 393-406 [PMID:27597415] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]