lanepitant [Ligand Id: 3510] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL42407 (Lanepitant) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| NK1 receptor/Neurokinin 1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL249] [GtoPdb: 360] [UniProtKB: P25103] | ||||||||
| ChEMBL | Inhibition of substance P induced contraction of rabbit vena ceva (RVC) tissue expressing Tachykinin receptor 1 | F | 9.4 | pKd | 0.4 | nM | Kd | J Med Chem (1996) 39: 736-748 [PMID:8576917] |
| GtoPdb | - | - | 10 | pKi | 0.1 | nM | Ki | J Pharmacol Exp Ther (1995) 275: 737-44 [PMID:7473161] |
| ChEMBL | In vitro inhibition of binding of [125I]Bolton-Hunter SP to Tachykinin receptor 1 in human IM-9 cell line | B | 9.64 | pIC50 | 0.23 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1643-1646 [PMID:11425527] |
| GtoPdb | - | - | 9.82 | pIC50 | 0.15 | nM | IC50 | Expert Opin Ther Pat (2010) 20: 1019-45 [PMID:20533894] |
| ChEMBL | Inhibitory activity against Tachykinin receptor 1 in human IM-9 cells using [125I]-labeled Boltan-Hunter substance P as radioligand | B | 9.82 | pIC50 | 0.15 | nM | IC50 | J Med Chem (1996) 39: 736-748 [PMID:8576917] |
| Neurokinin 2 receptor in Rabbit (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3433] [UniProtKB: P79218] | ||||||||
| ChEMBL | Inhibition of neurokinin A induced contraction of rabbit pulmonary artery (RPA) tissue expressing Tachykinin receptor 2 | F | 4.7 | pKd | 19952.62 | nM | Kd | J Med Chem (1996) 39: 736-748 [PMID:8576917] |
| NK3 receptor/Neurokinin 3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3154] [GtoPdb: 362] [UniProtKB: P16177] | ||||||||
| ChEMBL | Inhibition of neurokinin B induced contraction of rat portal vein (RPV) tissue expressing Tachykinin receptor 3 | F | 4.7 | pKd | 19952.62 | nM | Kd | J Med Chem (1996) 39: 736-748 [PMID:8576917] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
