ChEMBL ligand: CHEMBL1064 (C10AA01, Flolipid, Lacersa, MK-0733, MK-733, NSC-758706, Ranzolont, Simvador, Simvastatin, Simvastatin hydroxy acid, Synvinolin, Zocor, Zocor heart-pro)
3-hydroxy-3-methylglutaryl-coenzyme A reductase in Schizosaccharomyces pombe 972h- [ChEMBL: CHEMBL1163121] [UniProtKB: Q10283] There should be some charts here, you may need to enable JavaScript!
Acetylcholinesterase in Electrophorus electricus [ChEMBL: CHEMBL4078] [UniProtKB: O42275] There should be some charts here, you may need to enable JavaScript!
ABCC2/Canalicular multispecific organic anion transporter 1 in Human [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887] There should be some charts here, you may need to enable JavaScript!
Cholinesterase in Equus caballus [ChEMBL: CHEMBL5763] [UniProtKB: P81908] There should be some charts here, you may need to enable JavaScript!
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035] hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639] There should be some charts here, you may need to enable JavaScript!
ABCB1/P-glycoprotein 1 in Human [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183] There should be some charts here, you may need to enable JavaScript!
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
3-hydroxy-3-methylglutaryl-coenzyme A reductase in Schizosaccharomyces pombe 972h- (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1163121] [UniProtKB: Q10283]
ChEMBL	Inhibition of Schizosaccharomyces pombe HMG-CoA reductase by spectrophotometry	B	4.02	pIC50	95200	nM	IC50	Bioorg Med Chem (2010) 18: 4238-4248 [PMID:20576575]
Acetylcholinesterase in Electrophorus electricus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4078] [UniProtKB: O42275]
ChEMBL	Inhibition of Electrophorus electricus (electric eel) acetylcholinesterase (AChE) assessed as inhibition of ATCh hydrolysis by Ellman method	B	5.74	pKi	1800	nM	Ki	Med Chem Res (2005) 14: 297-308
ABCC2/Canalicular multispecific organic anion transporter 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5748] [GtoPdb: 780] [UniProtKB: Q92887]
ChEMBL	TP_TRANSPORTER: inhibition of calcein-AM efflux in MRP2-expressing MDCK cells	F	4.6	pIC50	25000	nM	IC50	Drug Metab Dispos (2005) 33: 537-546 [PMID:15616150]
Cholinesterase in Equus caballus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5763] [UniProtKB: P81908]
ChEMBL	Inhibition of Equus caballus (horse) serum butyrylcholinesterase (BChE) assessed as inhibition of BTCh hydrolysis by Ellman method	B	5.3	pKi	5011.87	nM	Ki	Med Chem Res (2005) 14: 297-308
ChEMBL	Inhibition of Equus caballus (horse) serum butyrylcholinesterase (BChE) assessed as inhibition of BTCh hydrolysis by Ellman method	B	6.12	pKi	750	nM	Ki	Med Chem Res (2005) 14: 297-308
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL402] [GtoPdb: 639] [UniProtKB: P04035]
ChEMBL	Inhibitory constant against HMG-CoA reductase with alpha asarone	B	4.17	pKi	68000	nM	Ki	Bioorg Med Chem Lett (2005) 15: 989-994 [PMID:15686898]
ChEMBL	Inhibitory constant against HMG-CoA reductase	B	8.59	pKi	2.6	nM	Ki	Bioorg Med Chem Lett (2005) 15: 989-994 [PMID:15686898]
ChEMBL	Inhibition of human HMG-CoA reductase activity using NADPH by spectrophotometrically	B	5.21	pIC50	6110	nM	IC50	Bioorg Med Chem (2014) 22: 5871-5882 [PMID:25311563]
ChEMBL	Inhibition of HMGCoA reductase	B	7.31	pIC50	49	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4531-4537 [PMID:17574411]
ChEMBL	Inhibition of HMG-CoA reductase	B	7.31	pIC50	49	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4538-4544 [PMID:17574412]
ChEMBL	Inhibition of human HMG-CoA reductase after 30 mins	B	7.4	pIC50	39.81	nM	IC50	Bioorg Med Chem (2014) 22: 5871-5882 [PMID:25311563]
GtoPdb	In vitro inhibition of HMG-CoA reductase	-	7.92	pIC50	12.1	nM	IC50	J Med Chem (1992) 35: 3813-21 [PMID:1433193]
ChEMBL	Inhibitory concentration against HMG-CoA reductase	B	7.95	pIC50	11.2	nM	IC50	Bioorg Med Chem Lett (2005) 15: 989-994 [PMID:15686898]
ChEMBL	Inhibitory concentration against 3-hydroxy-3-methylglutaryl-CoA reductase	B	7.96	pIC50	11	nM	IC50	Bioorg Med Chem Lett (2005) 15: 1027-1032 [PMID:15686906]
GtoPdb	-	-	7.96	pIC50	11	nM	IC50	Science (2001) 292: 1160-4 [PMID:11349148]
ChEMBL	DRUGMATRIX: HMG-CoA Reductase enzyme inhibition (substrate: [14C]HMG-CoA)	B	8.47	pIC50	3.39	nM	IC50	DrugMatrix in vitro pharmacology data
ChEMBL	Inhibition of HMG-CoA reductase (unknown origin) using [14C]-HMG-CoA as substrate after 5 mins in presence of NADPH	B	9.05	pIC50	0.9	nM	IC50	J Med Chem (2018) 61: 2166-2210 [PMID:28850227]
hydroxymethylglutaryl-CoA reductase/HMG-CoA reductase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3247] [GtoPdb: 639] [UniProtKB: P51639]
GtoPdb	In vitro inhibition of cellular cholesterol synthesis	-	6.82	pIC50	150	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4538-44 [PMID:17574412]
GtoPdb	In vitro inhibition of HMG-CoA reductase	-	7.31	pIC50	49	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4538-44 [PMID:17574412]
ChEMBL	Inhibition of rat microsomal HMG-CoA reductase assessed as inhibition of cholesterol synthesis after 30 mins	B	7.74	pIC50	18	nM	IC50	Bioorg Med Chem (2007) 15: 5576-5589 [PMID:17560788]
ChEMBL	Inhibition of HMGR in rat hepatic microsomes assessed as conversion of [14C]HMG-CoA to [14C]mevalonic acid	B	8.37	pIC50	4.3	nM	IC50	J Med Chem (2008) 51: 2722-2733 [PMID:18412317]
GtoPdb	in vitro inhibition of cholesterol synthesis	-	8.56	pIC50	2.74	nM	IC50	Am J Cardiol (2001) 87: 28B-32B [PMID:11256847]
GtoPdb	In vitro inhibition of cellular cholesterol synthesis	-	8.89	pIC50	1.3	nM	IC50	Bioorg Med Chem Lett (2007) 17: 4538-44 [PMID:17574412]
GtoPdb	Inhibition of HMG-CoA reductase	-	9.05	pIC50	0.9	nM	IC50	J Med Chem (1986) 29: 849-52 [PMID:3634830]
ABCB1/P-glycoprotein 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4302] [GtoPdb: 768] [UniProtKB: P08183]
ChEMBL	TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells	F	4.25	pIC50	56800	nM	IC50	Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL	TP_TRANSPORTER: inhibition of Rhodamine 123 transport in 3T3-G185 cells	F	4.34	pIC50	46000	nM	IC50	Pharm Res (2001) 18: 800-806 [PMID:11474784]
ChEMBL	TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells	F	4.58	pIC50	26100	nM	IC50	Biochem Biophys Res Commun (2001) 289: 580-585 [PMID:11716514]
ChEMBL	TP_TRANSPORTER: inhibition of calcein-AM efflux in MDR1-expressing MDCK cells	F	5	pIC50	10000	nM	IC50	Drug Metab Dispos (2005) 33: 537-546 [PMID:15616150]
ChEMBL	TP_TRANSPORTER: inhibition of Daunorubicin transport in 3T3-G185 cells	F	5.05	pIC50	9000	nM	IC50	Pharm Res (2001) 18: 800-806 [PMID:11474784]
OATP1B1/Solute carrier organic anion transporter family member 1B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1697668] [GtoPdb: 1220] [UniProtKB: Q9Y6L6]
ChEMBL	TP_TRANSPORTER: inhibition of estradiol-17beta-glucuronide uptake(estradiol-17beta-glucuronide:0.02uM) in OATP1B1-expressing HEK293 cells	F	5.01	pIC50	9700	nM	IC50	Drug Metab Dispos (2005) 33: 537-546 [PMID:15616150]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]