ChEMBL ligand: CHEMBL357076 (J-113397)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] There should be some charts here, you may need to enable JavaScript!
NOP receptor/Nociceptin receptor in Human [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
ChEMBL	Displacement of [3H]diprenorphine from human cloned delta type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Binding affinity in CHO cells stably expressing cloned human Opioid receptor delta 1 by displacing radioligand [3H][D-Ala2,D-Leu5]enkephalin	B	5	pIC50	>10000	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
ChEMBL	Displacement of [3H]naltrindole from cloned human delta opioid receptor expressed in CHO cells	B	5	pIC50	>10000	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from human cloned kappa type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Displacement of [3H]U-69593 from cloned human kappa opioid receptor expressed in CHO cells	B	5.8	pIC50	1600	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Binding affinity in CHO cells stably expressing cloned human Opioid receptor kappa 1 by displacing radioligand [3H]U-69593	B	5.85	pIC50	1400	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphine from human cloned mu type opioid receptor expressed in CHO cell membranes by scintillation counter	B	6.4	pKi	>400	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Displacement of [3H]diprenorphin from cloned human mu opioid receptor expressed in CHO cells	B	5.47	pIC50	3400	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Binding affinity in CHO cells stably expressing cloned human Opioid receptor mu 1 by displacing diprenorphine	B	5.66	pIC50	2200	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146]
ChEMBL	Binding affinity towards Nociceptin/orphanin FQ (N/OFQ) receptor from recombinant HEK293 cell membranes was determined using binding assay	B	8.64	pKi	2.3	nM	Ki	Bioorg Med Chem Lett (2004) 14: 1347-1351 [PMID:14980696]
GtoPdb	-	-	8.7	pKi	-	-	-	Eur J Pharmacol (2000) 402: 45-53 [PMID:10940356]
ChEMBL	Displacement of [3H]Nociceptin from human recombinant NOP receptor expressed in CHO cells by scintillation counter	B	9.39	pKi	0.4	nM	Ki	J Med Chem (2012) 55: 4955-4967 [PMID:22541041]
ChEMBL	Antagonistic activity against nociceptin produced [35S]GTP-gamma-S, binding to Opioid receptor like 1 expressed in CHO cells	F	8.25	pIC50	5.6	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
GtoPdb	-	-	8.3	pIC50	-	-	IC50	J Med Chem (1999) 42: 5061-3 [PMID:10602690]
ChEMBL	Displacement of [125I]Tyr-nociceptin from cloned human ORL1 expressed in CHO cells	B	8.62	pIC50	2.4	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Binding affinity in CHO cells stably expressing cloned human Opioid receptor like 1 by displacing radioligand [125I]Tyr14-nociceptin	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
ChEMBL	Displacement of [125I]Tyr14-nociceptin from human cloned ORL1 receptor expressed in CHO cells	B	8.64	pIC50	2.3	nM	IC50	J Med Chem (2009) 52: 4091-4094 [PMID:19537798]
ChEMBL	Antagonist activity on nociceptin-induced [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells	F	8.82	pIC50	1.5	nM	IC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]
ChEMBL	Agonistic activity against nociceptin produced GTPgammaS binding to Opioid receptor like 1 expressed in CHO cells	B	5	pEC50	>10000	nM	EC50	J Med Chem (1999) 42: 5061-5063 [PMID:10602690]
ChEMBL	Agonist activity on nociceptin-induced maximal [35S]GTP-gamma-S binding to ORL1 expressed in CHO cells	F	5	pEC50	>10000	nM	EC50	J Med Chem (2006) 49: 847-849 [PMID:16451050]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]