ChEMBL ligand: CHEMBL139000 (R-N6-(Phenylisopropyl)Adenosine)
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] Adenosine A1 receptor in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190] A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] Adenosine A2a receptor in Guinea pig [ChEMBL: CHEMBL2605] [UniProtKB: P46616] There should be some charts here, you may need to enable JavaScript!
A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] A2B receptor in Mouse [GtoPdb: 20] [UniProtKB: Q60614] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Displacement of [3H]DPCPX from human recombinant adenosine receptor A1 expressed in CHO cells after 90 mins	B	6.31	pKi	490	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Displacement of [3H]CPPA from human adenosine A1 receptor expressed in CHO cells	B	8.7	pKi	2	nM	Ki	J Med Chem (2007) 50: 1810-1827 [PMID:17378544]
ChEMBL	Binding affinity to adenosine A1 receptor (unknown origin)	B	8.7	pKi	2	nM	Ki	J Med Chem (2016) 59: 788-809 [PMID:26356532]
GtoPdb	-	-	8.7	pKi	-	-	-	J Biol Chem (1994) 269: 32077-84 [PMID:7798201]; J Biol Chem (1999) 274: 3617-21 [PMID:9920910]; J Biol Chem (1994) 269: 2373-6 [PMID:8300561]; Biochem Pharmacol (2004) 68: 1985-93 [PMID:15476669]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]
ChEMBL	Displacement of [3H]DPCPX from human recombinant adenosine receptor A1 expressed in CHO cells after 90 mins	B	6.08	pIC50	830	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cells	B	5.92	pEC50	1200	nM	EC50	J Nat Prod (2006) 69: 432-435 [PMID:16562853]
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL	Intrinsic activity towards Adenosine A1 receptor as displacement of [3H]DPCPX from bovine cortical membranes with 1 mM GTP	B	7.7	pKi	19.9	nM	Ki	J Med Chem (2001) 44: 316-327 [PMID:11462973]
ChEMBL	Intrinsic activity towards Adenosine A1 receptor as displacement of [3H]DPCPX from bovine cortical membranes without GTP	B	8.38	pKi	4.2	nM	Ki	J Med Chem (2001) 44: 316-327 [PMID:11462973]
ChEMBL	Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovine brain cortical membranes.	B	9.22	pKi	0.6	nM	Ki	J Med Chem (1998) 41: 1708-1715 [PMID:9572897]
ChEMBL	Ability to displace the specific binding of [3H]CHA to adenosine A1 receptor from bovine brain cortical membranes	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2000) 43: 2814-2823 [PMID:10956189]
ChEMBL	Antagonist binding of N6-cyclohexyl-[3H]-adenosine to bovine brain	B	9.6	pKi	0.25	nM	Ki	J Med Chem (1982) 25: 197-207 [PMID:6279840]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Binding affinity against low affinity component of adenosine A1 receptors from rat brain membranes using [3H]-DPCPX	B	6.7	pKi	200	nM	Ki	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Affinity for the Adenosine A1 receptor in the presence of GTP (A1+GTP) by using [3H]-DPCPX as radioligand	B	7.21	pKi	62	nM	Ki	J Med Chem (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL	Affinity for the Adenosine A1 receptor in the absence of GTP (A1-GTP) by using [3H]DPCPX as radioligand	B	7.96	pKi	11	nM	Ki	J Med Chem (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL	Evaluated for the binding affinity towards the Adenosine A1 receptor in corpora striata of rats using [3H]CHA as radioligand.	B	8.52	pKi	3	nM	Ki	J Med Chem (1990) 33: 2240-2254 [PMID:2374150]
ChEMBL	Displacement of [3H]R-PIA from adenosine A1 receptor of Wistar rat forebrain	B	8.59	pKi	2.6	nM	Ki	J Med Chem (1999) 42: 3463-3477 [PMID:10479279]
ChEMBL	Binding affinity against adenosine A1 receptors from rat brain membranes using [3H]CCPA	B	8.89	pKi	1.3	nM	Ki	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Displacement of [3H]PIA from adenosine A1 receptor of rat brain membranes	B	8.89	pKi	1.3	nM	Ki	J Med Chem (1988) 31: 1179-1183 [PMID:3373486]
GtoPdb	-	-	8.92	pKi	1.2	nM	Ki	Pharmacology (1993) 46: 91-100 [PMID:8441759]
ChEMBL	Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1992) 35: 407-422 [PMID:1738138]
ChEMBL	Binding affinity to adenosine A1 receptor in rat whole brain membranes by [3H]N6-cyclohexyladenosine displacement.	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1987) 30: 1709-1711 [PMID:2888894]
ChEMBL	Binding affinity at adenosine A1 receptor from rat brain membranes by [3H]N6-cyclohexyladenosine displacement.	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1988) 31: 1282-1285 [PMID:3385722]
ChEMBL	Binding affinity towards adenosine A1 receptor on rat whole brain membrane using [3H]N6-cyclohexyladenosine	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1988) 31: 271-273 [PMID:3336027]
ChEMBL	Inhibition of [3H]- (R)-P1A binding to adenosine A1 receptor	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1991) 34: 3388-3390 [PMID:1766003]
ChEMBL	Binding affinity for Adenosine A1 receptor in cerebral cortices of Sprague-Dawley male rats using [3H]-CHA	B	8.93	pKi	1.17	nM	Ki	J Med Chem (1990) 33: 2240-2254 [PMID:2374150]
ChEMBL	Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes.	B	8.93	pKi	1.17	nM	Ki	J Med Chem (1989) 32: 1667-1673 [PMID:2754691]
ChEMBL	Displacement of [3H]CHA from adenosine A1 receptor of rat whole brain	B	8.94	pKi	1.15	nM	Ki	J Med Chem (1985) 28: 1383-1384 [PMID:2995663]
ChEMBL	Binding affinity for adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand	B	8.96	pKi	1.1	nM	Ki	J Med Chem (1986) 29: 346-353 [PMID:3005574]
ChEMBL	Binding affinity against high affinity component of adenosine A1 receptors from rat brain membranes using [3H]DPCPX	B	9	pKi	1	nM	Ki	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Inhibition of [3H]CHA (N6-cyclohexyl adenosine) to rat brain membrane Adenosine A1 receptor	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2002) 45: 1196-1202 [PMID:11881988]
ChEMBL	Inhibition of Adenylate cyclase activity in rat fat cell membrane at adenosine A1 receptor	B	7.4	pIC50	40	nM	IC50	J Med Chem (1988) 31: 1179-1183 [PMID:3373486]
ChEMBL	Concentration required for 50% inhibition of [3H]-CHA binding on rat brain adenosine A1 receptor	B	8.3	pIC50	5	nM	IC50	J Med Chem (1991) 34: 2570-2579 [PMID:1875349]
ChEMBL	Evaluated for the binding affinity towards the Adenosine A1 receptor in cerebral cortices of Sprague-Dawley male rats using [3H]CHA as radioligand.	B	8.62	pIC50	2.4	nM	IC50	J Med Chem (1990) 33: 2240-2254 [PMID:2374150]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Displacement of [3H]CGS-21680 from human adenosine A2A receptor expressed in CHO cells	B	6.05	pKi	884	nM	Ki	J Med Chem (2007) 50: 1810-1827 [PMID:17378544]
ChEMBL	Inhibitory activity at Adenosine A2A receptor by inhibition of [3H]-CGS- 21680 binding to bovine striatal membranes.	B	6.12	pKi	750	nM	Ki	J Med Chem (1998) 41: 1708-1715 [PMID:9572897]
ChEMBL	Ability to displace the specific binding of [3H]-CGS- to adenosine A2A receptor form bovine brain striatal membranes	B	6.12	pKi	750	nM	Ki	J Med Chem (2000) 43: 2814-2823 [PMID:10956189]
GtoPdb	-	-	6.2	pKi	-	-	-	Biochem Pharmacol (2004) 68: 1985-93 [PMID:15476669]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; J Biol Chem (1995) 270: 13987-97 [PMID:7775460]; Biochem Pharmacol (1999) 57: 65-75 [PMID:9920286]; Br J Pharmacol (1997) 121: 353-60 [PMID:9179373]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
GtoPdb	-	-	6.66	pKi	220	nM	Ki	Pharmacology (1993) 46: 91-100 [PMID:8441759]
ChEMBL	Binding affinity against Adenosine A2A receptor by using [3H]CGS-21680 as radioligand	B	6.85	pKi	140	nM	Ki	J Med Chem (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL	Displacement of [3H]-CGS- 21680 from adenosine A2A receptor of rat striatal tissue	B	6.93	pKi	117	nM	Ki	J Med Chem (1999) 42: 3463-3477 [PMID:10479279]
Adenosine A2a receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2605] [UniProtKB: P46616]
ChEMBL	Antagonist binding of N6-cyclohexyl-[3H]-adenosine to guinea pig brain	B	8.48	pKi	3.3	nM	Ki	J Med Chem (1982) 25: 197-207 [PMID:6279840]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb	-	-	5.5	pKi	-	-	-	Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; Mol Pharmacol (1999) 56: 705-13 [PMID:10496952]; Biochem Pharmacol (2001) 61: 657-63 [PMID:11266650]; Mol Pharmacol (2000) 58: 1349-56 [PMID:11093773]; Can J Physiol Pharmacol (1980) 58: 673-91 [PMID:6253037]
ChEMBL	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	F	3.23	pEC50	-3.23	-	logEC50	J Med Chem (2008) 51: 2088-2099 [PMID:18321038]
ChEMBL	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	F	5.77	pEC50	1680	nM	EC50	J Med Chem (2007) 50: 1810-1827 [PMID:17378544]
A2B receptor in Mouse [GtoPdb: 20] [UniProtKB: Q60614]
GtoPdb	-	-	4.72	pKi	19000	nM	Ki	Biochem Pharmacol (1994) 47: 801-14 [PMID:8135856]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	Binding affinity to adenosine A3 receptor (unknown origin)	B	7.8	pKi	16	nM	Ki	J Med Chem (2016) 59: 788-809 [PMID:26356532]
ChEMBL	Affinity for human Adenosine A3 receptor expressed in CHO cell	B	8.06	pKi	8.7	nM	Ki	J Med Chem (2002) 45: 4471-4484 [PMID:12238926]
ChEMBL	Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells	B	8.06	pKi	8.7	nM	Ki	J Med Chem (2007) 50: 1810-1827 [PMID:17378544]
GtoPdb	-	-	8.1	pKi	-	-	-	Proc Natl Acad Sci USA (1993) 90: 10365-9 [PMID:8234299]; Biochem Pharmacol (2004) 68: 1985-93 [PMID:15476669]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; Mol Pharmacol (2000) 57: 968-75 [PMID:10779381]; Neuropharmacology (1997) 36: 1157-65 [PMID:9364471]
ChEMBL	Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor	F	7.57	pEC50	27	nM	EC50	J Med Chem (2002) 45: 4471-4484 [PMID:12238926]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
GtoPdb	-	-	6.8	pKi	-	-	-	J Biol Chem (1994) 269: 24692-8 [PMID:7929142]; Pharmacology (1993) 46: 91-100 [PMID:8441759]
ChEMBL	Inhibitory activity against Adenosine A3 receptor by inhibiting specific [3H](R)-PIA binding to rat testis membranes	B	7.28	pKi	53	nM	Ki	J Med Chem (1998) 41: 1708-1715 [PMID:9572897]
ChEMBL	Affinity to Adenosine A3 receptor of rat testis membrane using [3H](R)-PIA with 150 nM DPCPX	B	7.28	pKi	53	nM	Ki	J Med Chem (2002) 45: 1196-1202 [PMID:11881988]
ChEMBL	Ability to displace the specific binding of [3H](R)-PIA to adenosine A3 receptor from rat testis membranes	B	7.28	pKi	53	nM	Ki	J Med Chem (2000) 43: 2814-2823 [PMID:10956189]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]