ChEMBL ligand: CHEMBL139000 (R-N6-(Phenylisopropyl)Adenosine)
A1 receptor/Adenosine A1 receptor in Human [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542] Adenosine A1 receptor in Bovine [ChEMBL: CHEMBL4975] [UniProtKB: P28190] A1 receptor/Adenosine A1 receptor in Rat [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099] There should be some charts here, you may need to enable JavaScript!
A2A receptor/Adenosine A2a receptor in Human [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274] A2A receptor/Adenosine A2a receptor in Rat [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543] Adenosine A2a receptor in Guinea pig [ChEMBL: CHEMBL2605] [UniProtKB: P46616] There should be some charts here, you may need to enable JavaScript!
A2B receptor/Adenosine A2b receptor in Human [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275] A2B receptor in Mouse [GtoPdb: 20] [UniProtKB: Q60614] There should be some charts here, you may need to enable JavaScript!
A3 receptor/Adenosine A3 receptor in Human [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8] A3 receptor/Adenosine A3 receptor in Rat [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
A1 receptor/Adenosine A1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL226] [GtoPdb: 18] [UniProtKB: P30542]
ChEMBL	Displacement of [3H]DPCPX from human recombinant adenosine receptor A1 expressed in CHO cells after 90 mins	B	6.31	pKi	490	nM	Ki	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Displacement of [3H]CPPA from human adenosine A1 receptor expressed in CHO cells	B	8.7	pKi	2	nM	Ki	J Med Chem (2007) 50: 1810-1827 [PMID:17378544]
ChEMBL	Binding affinity to adenosine A1 receptor (unknown origin)	B	8.7	pKi	2	nM	Ki	J Med Chem (2016) 59: 788-809 [PMID:26356532]
GtoPdb	-	-	8.7	pKi	-	-	-	J Biol Chem (1994) 269: 32077-84 [PMID:7798201]; J Biol Chem (1999) 274: 3617-21 [PMID:9920910]; J Biol Chem (1994) 269: 2373-6 [PMID:8300561]; Biochem Pharmacol (2004) 68: 1985-93 [PMID:15476669]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]
ChEMBL	Displacement of [3H]DPCPX from human recombinant adenosine receptor A1 expressed in CHO cells after 90 mins	B	6.08	pIC50	830	nM	IC50	Bioorg Med Chem Lett (2013) 23: 1834-1838 [PMID:23403082]
ChEMBL	Displacement of [3H]DPCPX from human recombinant adenosine A1 receptor expressed in CHO cells	B	5.92	pEC50	1200	nM	EC50	J Nat Prod (2006) 69: 432-435 [PMID:16562853]
Adenosine A1 receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4975] [UniProtKB: P28190]
ChEMBL	Intrinsic activity towards Adenosine A1 receptor as displacement of [3H]DPCPX from bovine cortical membranes with 1 mM GTP	B	7.7	pKi	19.9	nM	Ki	J Med Chem (2001) 44: 316-327 [PMID:11462973]
ChEMBL	Intrinsic activity towards Adenosine A1 receptor as displacement of [3H]DPCPX from bovine cortical membranes without GTP	B	8.38	pKi	4.2	nM	Ki	J Med Chem (2001) 44: 316-327 [PMID:11462973]
ChEMBL	Inhibitory activity at Adenosine A1 receptor by inhibition of [3H]CHA binding to bovine brain cortical membranes.	B	9.22	pKi	0.6	nM	Ki	J Med Chem (1998) 41: 1708-1715 [PMID:9572897]
ChEMBL	Ability to displace the specific binding of [3H]CHA to adenosine A1 receptor from bovine brain cortical membranes	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2000) 43: 2814-2823 [PMID:10956189]
ChEMBL	Antagonist binding of N6-cyclohexyl-[3H]-adenosine to bovine brain	B	9.6	pKi	0.25	nM	Ki	J Med Chem (1982) 25: 197-207 [PMID:6279840]
A1 receptor/Adenosine A1 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL318] [GtoPdb: 18] [UniProtKB: P25099]
ChEMBL	Binding affinity against low affinity component of adenosine A1 receptors from rat brain membranes using [3H]-DPCPX	B	6.7	pKi	200	nM	Ki	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Affinity for the Adenosine A1 receptor in the presence of GTP (A1+GTP) by using [3H]-DPCPX as radioligand	B	7.21	pKi	62	nM	Ki	J Med Chem (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL	Affinity for the Adenosine A1 receptor in the absence of GTP (A1-GTP) by using [3H]DPCPX as radioligand	B	7.96	pKi	11	nM	Ki	J Med Chem (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL	Evaluated for the binding affinity towards the Adenosine A1 receptor in corpora striata of rats using [3H]CHA as radioligand.	B	8.52	pKi	3	nM	Ki	J Med Chem (1990) 33: 2240-2254 [PMID:2374150]
ChEMBL	Displacement of [3H]R-PIA from adenosine A1 receptor of Wistar rat forebrain	B	8.59	pKi	2.6	nM	Ki	J Med Chem (1999) 42: 3463-3477 [PMID:10479279]
ChEMBL	Binding affinity against adenosine A1 receptors from rat brain membranes using [3H]CCPA	B	8.89	pKi	1.3	nM	Ki	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Displacement of [3H]PIA from adenosine A1 receptor of rat brain membranes	B	8.89	pKi	1.3	nM	Ki	J Med Chem (1988) 31: 1179-1183 [PMID:3373486]
GtoPdb	-	-	8.92	pKi	1.2	nM	Ki	Pharmacology (1993) 46: 91-100 [PMID:8441759]
ChEMBL	Binding affinity against adenosine A1 receptor using [3H]-CHA or [3H]PIA as radioligand	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1992) 35: 407-422 [PMID:1738138]
ChEMBL	Binding affinity to adenosine A1 receptor in rat whole brain membranes by [3H]N6-cyclohexyladenosine displacement.	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1987) 30: 1709-1711 [PMID:2888894]
ChEMBL	Binding affinity at adenosine A1 receptor from rat brain membranes by [3H]N6-cyclohexyladenosine displacement.	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1988) 31: 1282-1285 [PMID:3385722]
ChEMBL	Binding affinity towards adenosine A1 receptor on rat whole brain membrane using [3H]N6-cyclohexyladenosine	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1988) 31: 271-273 [PMID:3336027]
ChEMBL	Inhibition of [3H]- (R)-P1A binding to adenosine A1 receptor	B	8.92	pKi	1.2	nM	Ki	J Med Chem (1991) 34: 3388-3390 [PMID:1766003]
ChEMBL	Binding affinity for Adenosine A1 receptor in cerebral cortices of Sprague-Dawley male rats using [3H]-CHA	B	8.93	pKi	1.17	nM	Ki	J Med Chem (1990) 33: 2240-2254 [PMID:2374150]
ChEMBL	Inhibition of binding of [3H]N6-cyclohexyladenosine to adenosine A1 receptor of rat whole brain membranes.	B	8.93	pKi	1.17	nM	Ki	J Med Chem (1989) 32: 1667-1673 [PMID:2754691]
ChEMBL	Displacement of [3H]CHA from adenosine A1 receptor of rat whole brain	B	8.94	pKi	1.15	nM	Ki	J Med Chem (1985) 28: 1383-1384 [PMID:2995663]
ChEMBL	Binding affinity for adenosine A1 receptor in rat brain membranes using [3H]CHA as radioligand	B	8.96	pKi	1.1	nM	Ki	J Med Chem (1986) 29: 346-353 [PMID:3005574]
ChEMBL	Binding affinity against high affinity component of adenosine A1 receptors from rat brain membranes using [3H]DPCPX	B	9	pKi	1	nM	Ki	J Med Chem (1992) 35: 2363-2368 [PMID:1619615]
ChEMBL	Inhibition of [3H]CHA (N6-cyclohexyl adenosine) to rat brain membrane Adenosine A1 receptor	B	9.22	pKi	0.6	nM	Ki	J Med Chem (2002) 45: 1196-1202 [PMID:11881988]
ChEMBL	Inhibition of Adenylate cyclase activity in rat fat cell membrane at adenosine A1 receptor	B	7.4	pIC50	40	nM	IC50	J Med Chem (1988) 31: 1179-1183 [PMID:3373486]
ChEMBL	Concentration required for 50% inhibition of [3H]-CHA binding on rat brain adenosine A1 receptor	B	8.3	pIC50	5	nM	IC50	J Med Chem (1991) 34: 2570-2579 [PMID:1875349]
ChEMBL	Evaluated for the binding affinity towards the Adenosine A1 receptor in cerebral cortices of Sprague-Dawley male rats using [3H]CHA as radioligand.	B	8.62	pIC50	2.4	nM	IC50	J Med Chem (1990) 33: 2240-2254 [PMID:2374150]
A2A receptor/Adenosine A2a receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL251] [GtoPdb: 19] [UniProtKB: P29274]
ChEMBL	Displacement of [3H]CGS-21680 from human adenosine A2A receptor expressed in CHO cells	B	6.05	pKi	884	nM	Ki	J Med Chem (2007) 50: 1810-1827 [PMID:17378544]
ChEMBL	Inhibitory activity at Adenosine A2A receptor by inhibition of [3H]-CGS- 21680 binding to bovine striatal membranes.	B	6.12	pKi	750	nM	Ki	J Med Chem (1998) 41: 1708-1715 [PMID:9572897]
ChEMBL	Ability to displace the specific binding of [3H]-CGS- to adenosine A2A receptor form bovine brain striatal membranes	B	6.12	pKi	750	nM	Ki	J Med Chem (2000) 43: 2814-2823 [PMID:10956189]
GtoPdb	-	-	6.2	pKi	-	-	-	Biochem Pharmacol (2004) 68: 1985-93 [PMID:15476669]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; J Biol Chem (1995) 270: 13987-97 [PMID:7775460]; Biochem Pharmacol (1999) 57: 65-75 [PMID:9920286]; Br J Pharmacol (1997) 121: 353-60 [PMID:9179373]
A2A receptor/Adenosine A2a receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL302] [GtoPdb: 19] [UniProtKB: P30543]
GtoPdb	-	-	6.66	pKi	220	nM	Ki	Pharmacology (1993) 46: 91-100 [PMID:8441759]
ChEMBL	Binding affinity against Adenosine A2A receptor by using [3H]CGS-21680 as radioligand	B	6.85	pKi	140	nM	Ki	J Med Chem (1995) 38: 4000-4006 [PMID:7562934]
ChEMBL	Displacement of [3H]-CGS- 21680 from adenosine A2A receptor of rat striatal tissue	B	6.93	pKi	117	nM	Ki	J Med Chem (1999) 42: 3463-3477 [PMID:10479279]
Adenosine A2a receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2605] [UniProtKB: P46616]
ChEMBL	Antagonist binding of N6-cyclohexyl-[3H]-adenosine to guinea pig brain	B	8.48	pKi	3.3	nM	Ki	J Med Chem (1982) 25: 197-207 [PMID:6279840]
A2B receptor/Adenosine A2b receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL255] [GtoPdb: 20] [UniProtKB: P29275]
GtoPdb	-	-	5.5	pKi	-	-	-	Biochem Pharmacol (2005) 70: 1601-12 [PMID:16219300]; Mol Pharmacol (1999) 56: 705-13 [PMID:10496952]; Biochem Pharmacol (2001) 61: 657-63 [PMID:11266650]; Mol Pharmacol (2000) 58: 1349-56 [PMID:11093773]; Can J Physiol Pharmacol (1980) 58: 673-91 [PMID:6253037]
ChEMBL	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of adenylate cyclase	F	3.23	pEC50	-3.23	-	logEC50	J Med Chem (2008) 51: 2088-2099 [PMID:18321038]
ChEMBL	Agonist activity at human adenosine A2B receptor expressed in CHO cells assessed as stimulation of cAMP production	F	5.77	pEC50	1680	nM	EC50	J Med Chem (2007) 50: 1810-1827 [PMID:17378544]
A2B receptor in Mouse [GtoPdb: 20] [UniProtKB: Q60614]
GtoPdb	-	-	4.72	pKi	19000	nM	Ki	Biochem Pharmacol (1994) 47: 801-14 [PMID:8135856]
A3 receptor/Adenosine A3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL256] [GtoPdb: 21] [UniProtKB: P0DMS8]
ChEMBL	Binding affinity to adenosine A3 receptor (unknown origin)	B	7.8	pKi	16	nM	Ki	J Med Chem (2016) 59: 788-809 [PMID:26356532]
ChEMBL	Affinity for human Adenosine A3 receptor expressed in CHO cell	B	8.06	pKi	8.7	nM	Ki	J Med Chem (2002) 45: 4471-4484 [PMID:12238926]
ChEMBL	Displacement of [125I]I-AB-MECA from human adenosine A3 receptor expressed in CHO cells	B	8.06	pKi	8.7	nM	Ki	J Med Chem (2007) 50: 1810-1827 [PMID:17378544]
GtoPdb	-	-	8.1	pKi	-	-	-	Proc Natl Acad Sci USA (1993) 90: 10365-9 [PMID:8234299]; Biochem Pharmacol (2004) 68: 1985-93 [PMID:15476669]; Naunyn Schmiedebergs Arch Pharmacol (1998) 357: 1-9 [PMID:9459566]; Mol Pharmacol (2000) 57: 968-75 [PMID:10779381]; Neuropharmacology (1997) 36: 1157-65 [PMID:9364471]
ChEMBL	Effect on forskolin-stimulated cyclic AMP production in intact chinese hamster ovary (CHO) cell expressing the human Adenosine A3 receptor	F	7.57	pEC50	27	nM	EC50	J Med Chem (2002) 45: 4471-4484 [PMID:12238926]
A3 receptor/Adenosine A3 receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3360] [GtoPdb: 21] [UniProtKB: P28647]
GtoPdb	-	-	6.8	pKi	-	-	-	J Biol Chem (1994) 269: 24692-8 [PMID:7929142]; Pharmacology (1993) 46: 91-100 [PMID:8441759]
ChEMBL	Inhibitory activity against Adenosine A3 receptor by inhibiting specific [3H](R)-PIA binding to rat testis membranes	B	7.28	pKi	53	nM	Ki	J Med Chem (1998) 41: 1708-1715 [PMID:9572897]
ChEMBL	Affinity to Adenosine A3 receptor of rat testis membrane using [3H](R)-PIA with 150 nM DPCPX	B	7.28	pKi	53	nM	Ki	J Med Chem (2002) 45: 1196-1202 [PMID:11881988]
ChEMBL	Ability to displace the specific binding of [3H](R)-PIA to adenosine A3 receptor from rat testis membranes	B	7.28	pKi	53	nM	Ki	J Med Chem (2000) 43: 2814-2823 [PMID:10956189]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]