ChEMBL ligand: CHEMBL25230 (BW-373U86, SNC-86)
δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] δ receptor/Delta opioid receptor in Mouse [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] δ receptor/Delta opioid receptor in Rat [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] There should be some charts here, you may need to enable JavaScript!
κ receptor/Kappa opioid receptor in Human [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975] There should be some charts here, you may need to enable JavaScript!
μ receptor/Mu opioid receptor in Human [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] μ receptor/Mu opioid receptor in Rat [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb	-	-	9.49	pKi	0.32	nM	Ki	J Med Chem (2008) 51: 5893-6 [PMID:18788723]
ChEMBL	Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cells	B	9.49	pKi	0.32	nM	Ki	J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
ChEMBL	Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligand	B	9.64	pIC50	0.23	nM	IC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
ChEMBL	Agonist activity at human delta opioid receptor in CHO cells assessed as stimulation of [35S]GTPgammaS binding	F	9.4	pEC50	0.4	nM	EC50	J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
ChEMBL	Agonist potency was measured using GTP gamma-[35S] binding assay	B	9.92	pEC50	0.12	nM	EC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300]
ChEMBL	Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligand	B	9.04	pKi	0.91	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligand	B	9.04	pKi	0.91	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
ChEMBL	Agonist activity at delta opioid receptor in mouse vas deferens	F	9.2	pIC50	0.63	nM	IC50	Bioorg Med Chem Lett (2006) 16: 905-910 [PMID:16290934]
ChEMBL	Tested for inhibition of binding of [3H]DADLE to mouse brain membranes depleted of mu binding sites by pretreatment with irreversible ligand BIT for delta opioid receptor	B	9.51	pIC50	0.31	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533]
GtoPdb	-	-	8.74	pKi	1.8	nM	Ki	J Pharmacol Exp Ther (1993) 267: 852-7 [PMID:8246159]
ChEMBL	Binding affinity of compound evaluated for Opioid receptor delta 1 isolated from rat brain	B	8.74	pKi	1.8	nM	Ki	J Med Chem (2003) 46: 623-633 [PMID:12570383]
ChEMBL	Affinity of [H]DADLE to the delta opioid receptor from rat brain	B	9.04	pKi	0.91	nM	Ki	J Med Chem (2001) 44: 972-987 [PMID:11300879]
ChEMBL	Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1	B	7.23	pIC50	58.3	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1	B	8.83	pIC50	1.49	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Binding affinity was measured against Opioid receptor delta 1 using [3H]p-Cl-DPDPE as radioligand.	B	9.51	pIC50	0.31	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145]
ChEMBL	Displacement of [3H]diprenorphine from human kappa opioid receptor in CHO cells	B	5.47	pKi	3400	nM	Ki	J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
ChEMBL	Displacement of [3H]diprenorphine from human kappa opioid receptor in CHO cells at 10 uM	B	6.89	pKi	130	nM	Ki	J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
GtoPdb	-	-	6.89	pKi	130	nM	Ki	J Med Chem (2008) 51: 5893-6 [PMID:18788723]
ChEMBL	Binding affinity against cloned human Opioid receptor kappa 1 using [125I]-D-Pro10-dynorphin A[1-11] as radioligand	B	7.7	pIC50	20	nM	IC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975]
GtoPdb	-	-	7.47	pKi	34	nM	Ki	J Pharmacol Exp Ther (1993) 267: 852-7 [PMID:8246159]
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372]
ChEMBL	Displacement of [3H]diprenorphine from human mu opioid receptor in CHO cells	B	6.59	pKi	260	nM	Ki	J Med Chem (2008) 51: 5893-5896 [PMID:18788723]
GtoPdb	-	-	6.59	pKi	260	nM	Ki	J Med Chem (2008) 51: 5893-6 [PMID:18788723]
ChEMBL	Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 as radioligand	B	8.68	pIC50	2.1	nM	IC50	J Med Chem (2000) 43: 3878-3894 [PMID:11052793]
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535]
ChEMBL	Affinity of [3H]DAMGO to the mu opioid receptor from rat brain	B	7.44	pKi	36	nM	Ki	J Med Chem (2001) 44: 972-987 [PMID:11300879]
ChEMBL	Binding affinity towards opioid Mu receptor using [3H]DAMGO as radioligand	B	7.44	pKi	36	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174]
ChEMBL	Binding affinity towards opioid Mu receptor using [3H]DAMGO as radioligand	B	7.44	pKi	36	nM	Ki	Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597]
GtoPdb	-	-	7.82	pKi	15	nM	Ki	J Pharmacol Exp Ther (1993) 267: 852-7 [PMID:8246159]
ChEMBL	Inhibition of [3H]DAMGO binding to mu opioid receptor of rat brain membranes	B	7.82	pKi	15	nM	Ki	J Med Chem (2003) 46: 623-633 [PMID:12570383]
ChEMBL	Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO	B	5.63	pIC50	2322	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO	B	8.01	pIC50	9.71	nM	IC50	J Med Chem (1997) 40: 695-704 [PMID:9057856]
ChEMBL	Evaluated for inhibition of [3H]DAMGO binding from mu receptor in rat brain membranes	B	8.01	pIC50	9.71	nM	IC50	J Med Chem (1994) 37: 2125-2128 [PMID:8035418]
ChEMBL	Binding affinity was measured against Opioid receptor mu 1 using [3H]-DAMGO as radioligand.	B	8.01	pIC50	9.7	nM	IC50	J Med Chem (1998) 41: 4767-4776 [PMID:9822547]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]