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ChEMBL ligand: CHEMBL25230 (BW-373U86, SNC-86) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
GtoPdb | - | - | 9.49 | pKi | 0.32 | nM | Ki | J Med Chem (2008) 51: 5893-6 [PMID:18788723] |
ChEMBL | Displacement of [3H]diprenorphine from human delta opioid receptor in CHO cells | B | 9.49 | pKi | 0.32 | nM | Ki | J Med Chem (2008) 51: 5893-5896 [PMID:18788723] |
ChEMBL | Binding affinity against human opioid receptor delta 1 using [125I]-[D-Ala2]-deltorphin II as radioligand | B | 9.64 | pIC50 | 0.23 | nM | IC50 | J Med Chem (2000) 43: 3878-3894 [PMID:11052793] |
ChEMBL | Agonist activity at human delta opioid receptor in CHO cells assessed as stimulation of [35S]GTPgammaS binding | F | 9.4 | pEC50 | 0.4 | nM | EC50 | J Med Chem (2008) 51: 5893-5896 [PMID:18788723] |
ChEMBL | Agonist potency was measured using GTP gamma-[35S] binding assay | B | 9.92 | pEC50 | 0.12 | nM | EC50 | J Med Chem (2000) 43: 3878-3894 [PMID:11052793] |
δ receptor/Delta opioid receptor in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3222] [GtoPdb: 317] [UniProtKB: P32300] | ||||||||
ChEMBL | Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligand | B | 9.04 | pKi | 0.91 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174] |
ChEMBL | Binding affinity towards opioid Delta receptor using [3H]DADLE as radioligand | B | 9.04 | pKi | 0.91 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597] |
ChEMBL | Agonist activity at delta opioid receptor in mouse vas deferens | F | 9.2 | pIC50 | 0.63 | nM | IC50 | Bioorg Med Chem Lett (2006) 16: 905-910 [PMID:16290934] |
ChEMBL | Tested for inhibition of binding of [3H]DADLE to mouse brain membranes depleted of mu binding sites by pretreatment with irreversible ligand BIT for delta opioid receptor | B | 9.51 | pIC50 | 0.31 | nM | IC50 | J Med Chem (1994) 37: 2125-2128 [PMID:8035418] |
δ receptor/Delta opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL269] [GtoPdb: 317] [UniProtKB: P33533] | ||||||||
GtoPdb | - | - | 8.74 | pKi | 1.8 | nM | Ki | J Pharmacol Exp Ther (1993) 267: 852-7 [PMID:8246159] |
ChEMBL | Binding affinity of compound evaluated for Opioid receptor delta 1 isolated from rat brain | B | 8.74 | pKi | 1.8 | nM | Ki | J Med Chem (2003) 46: 623-633 [PMID:12570383] |
ChEMBL | Affinity of [H]DADLE to the delta opioid receptor from rat brain | B | 9.04 | pKi | 0.91 | nM | Ki | J Med Chem (2001) 44: 972-987 [PMID:11300879] |
ChEMBL | Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1 | B | 7.23 | pIC50 | 58.3 | nM | IC50 | J Med Chem (1997) 40: 695-704 [PMID:9057856] |
ChEMBL | Inhibition of radioligand [3H]DADLE binding to rat brain Opioid receptor delta 1 | B | 8.83 | pIC50 | 1.49 | nM | IC50 | J Med Chem (1997) 40: 695-704 [PMID:9057856] |
ChEMBL | Binding affinity was measured against Opioid receptor delta 1 using [3H]p-Cl-DPDPE as radioligand. | B | 9.51 | pIC50 | 0.31 | nM | IC50 | J Med Chem (1998) 41: 4767-4776 [PMID:9822547] |
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
ChEMBL | Displacement of [3H]diprenorphine from human kappa opioid receptor in CHO cells | B | 5.47 | pKi | 3400 | nM | Ki | J Med Chem (2008) 51: 5893-5896 [PMID:18788723] |
ChEMBL | Displacement of [3H]diprenorphine from human kappa opioid receptor in CHO cells at 10 uM | B | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2008) 51: 5893-5896 [PMID:18788723] |
GtoPdb | - | - | 6.89 | pKi | 130 | nM | Ki | J Med Chem (2008) 51: 5893-6 [PMID:18788723] |
ChEMBL | Binding affinity against cloned human Opioid receptor kappa 1 using [125I]-D-Pro10-dynorphin A[1-11] as radioligand | B | 7.7 | pIC50 | 20 | nM | IC50 | J Med Chem (2000) 43: 3878-3894 [PMID:11052793] |
κ receptor in Rat [GtoPdb: 318] [UniProtKB: P34975] | ||||||||
GtoPdb | - | - | 7.47 | pKi | 34 | nM | Ki | J Pharmacol Exp Ther (1993) 267: 852-7 [PMID:8246159] |
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Displacement of [3H]diprenorphine from human mu opioid receptor in CHO cells | B | 6.59 | pKi | 260 | nM | Ki | J Med Chem (2008) 51: 5893-5896 [PMID:18788723] |
GtoPdb | - | - | 6.59 | pKi | 260 | nM | Ki | J Med Chem (2008) 51: 5893-6 [PMID:18788723] |
ChEMBL | Binding affinity against cloned human Opioid receptor mu 1 using [125I]FK33824 as radioligand | B | 8.68 | pIC50 | 2.1 | nM | IC50 | J Med Chem (2000) 43: 3878-3894 [PMID:11052793] |
μ receptor/Mu opioid receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL270] [GtoPdb: 319] [UniProtKB: P33535] | ||||||||
ChEMBL | Affinity of [3H]DAMGO to the mu opioid receptor from rat brain | B | 7.44 | pKi | 36 | nM | Ki | J Med Chem (2001) 44: 972-987 [PMID:11300879] |
ChEMBL | Binding affinity towards opioid Mu receptor using [3H]DAMGO as radioligand | B | 7.44 | pKi | 36 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3053-3056 [PMID:10571174] |
ChEMBL | Binding affinity towards opioid Mu receptor using [3H]DAMGO as radioligand | B | 7.44 | pKi | 36 | nM | Ki | Bioorg Med Chem Lett (1999) 9: 3347-3350 [PMID:10612597] |
GtoPdb | - | - | 7.82 | pKi | 15 | nM | Ki | J Pharmacol Exp Ther (1993) 267: 852-7 [PMID:8246159] |
ChEMBL | Inhibition of [3H]DAMGO binding to mu opioid receptor of rat brain membranes | B | 7.82 | pKi | 15 | nM | Ki | J Med Chem (2003) 46: 623-633 [PMID:12570383] |
ChEMBL | Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO | B | 5.63 | pIC50 | 2322 | nM | IC50 | J Med Chem (1997) 40: 695-704 [PMID:9057856] |
ChEMBL | Inhibition of radioligand [3H]DAMGO binding to rat brain Opioid receptor mu 1 using 100 nM DAMGO | B | 8.01 | pIC50 | 9.71 | nM | IC50 | J Med Chem (1997) 40: 695-704 [PMID:9057856] |
ChEMBL | Evaluated for inhibition of [3H]DAMGO binding from mu receptor in rat brain membranes | B | 8.01 | pIC50 | 9.71 | nM | IC50 | J Med Chem (1994) 37: 2125-2128 [PMID:8035418] |
ChEMBL | Binding affinity was measured against Opioid receptor mu 1 using [3H]-DAMGO as radioligand. | B | 8.01 | pIC50 | 9.7 | nM | IC50 | J Med Chem (1998) 41: 4767-4776 [PMID:9822547] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]