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Compound class:
Antibody
Comment: NP137 (Netris Pharma) is a clinical lead anti-netrin 1 IgG1 monoclonal antibody [1]. It was developed as a novel anti-cancer therapeutic. The netrin 1 epitope recognised by NP137 is 90% homologous to the analogous region in netrin 3, suggesting cross-reactivity, and the potential for NP137 to be deployed against netrin 3-expressing tumours [2]. Antibody binding disrupts the netrin 1/UNC5B interaction.
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