gemifloxacin [Ligand Id: 12406] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL430 (Factiv, Gemifloxacin, Gemifloxacine, Gemifloxacino)
  • dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Topoisomerase IV subunit A in S.aureus [ChEMBL: CHEMBL4088] [UniProtKB: P0C1U9]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
dipeptidyl peptidase 4/Dipeptidyl peptidase IV in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL284] [GtoPdb: 1612] [UniProtKB: P27487]
ChEMBL Inhibition of DPP-4 (unknown origin) B 5.57 pIC50 2700 nM IC50 Bioorg Med Chem (2021) 46: 116354-116354 [PMID:34428715]
DNA gyrase subunit A/DNA gyrase subunit B/DNA gyrase in Escherichia coli (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094139] [GtoPdb: 3217, 3218] [UniProtKB: P0AES4, P0AES6]
ChEMBL Inhibitory activity against wild type Escherichia coli gyrase B 6.3 pIC50 500 nM IC50 Bioorg Med Chem Lett (2006) 16: 1272-1276 [PMID:16337791]
DNA gyrase in S.aureus (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL3038482] [UniProtKB: P0A0K8, P20831]
ChEMBL Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay B 5.25 pIC50 5600 nM IC50 J Med Chem (2007) 50: 199-210 [PMID:17228862]
ChEMBL Inhibition of Staphylococcus aureus wild-type DNA gyrase supercoiling activity assessed as effect on conversion of relaxed pBR322 DNA to supercoiled form B 5.25 pIC50 5600 nM IC50 Antimicrob Agents Chemother (2007) 51: 2445-2453 [PMID:17502409]
ChEMBL Inhibition of wild-type Staphylococcus aureus DNA gyrase assessed as inhibition of supercoiling of pBR322 DNA after 60 min by gel electrophoresis assay B 5.25 pIC50 5600 nM IC50 J Med Chem (2011) 54: 3268-3282 [PMID:21425851]
ChEMBL Inhibition of Staphylococcus aureus DNA gyrase by supercoiling assay B 5.25 pIC50 5600 nM IC50 J Med Chem (2011) 54: 3418-3425 [PMID:21443219]
Topoisomerase IV subunit A in S.aureus (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4088] [UniProtKB: P0C1U9]
ChEMBL Inhibitory activity against wild type Staphylococcus aureus topoisomerase 4 B 6.52 pIC50 300 nM IC50 Bioorg Med Chem Lett (2006) 16: 1272-1276 [PMID:16337791]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]