example 320 [WO2018198077A2] [Ligand Id: 12662] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4439972 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| large tumor suppressor kinase 1/Serine/threonine-protein kinase LATS1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6167] [GtoPdb: 1515] [UniProtKB: O95835] | ||||||||
| GtoPdb | Inhibition of human LATS1 kinase domain determined in a biochemical fluorescence-based assay | - | 9.15 | pIC50 | 0.7 | nM | IC50 | WO2018198077A2. 6-6 fused bicyclic heteroaryl compounds and their use as lats inhibitors (2018) |
| ChEMBL | Inhibition of human LATS1 kinase domain (589 to 1130 amino acids) incubated for 1 hr in presence of Fluo-SGKtide substrate by fluorescence detection based biochemical caliper assay | B | 9.15 | pIC50 | 0.7 | nM | IC50 | US-20180344738-A1. 6-6 Fused Bicyclic Heteroaryl Compounds and their Use as LATS Inhibitors (null) |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
