elafibranor   Click here for help

GtoPdb Ligand ID: 11135

Synonyms: GFT-505 | GFT505 | Iqirvo®
Approved drug PDB Ligand
elafibranor is an approved drug (EMA & FDA (2024))
Compound class: Synthetic organic
Comment: Elafibranor (GFT-505) is a PPARα/δ agonist.
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2D Structure
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Physico-chemical Properties
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Hydrogen bond acceptors 3
Hydrogen bond donors 1
Rotatable bonds 7
Topological polar surface area 88.9
Molecular weight 384.14
XLogP 4.97
No. Lipinski's rules broken 0

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

SMILES / InChI / InChIKey
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Canonical SMILES CSc1ccc(cc1)C(=O)/C=C/c1cc(C)c(c(c1)C)OC(C(=O)O)(C)C
Isomeric SMILES CSc1ccc(cc1)C(=O)/C=C/c1cc(C)c(c(c1)C)OC(C(=O)O)(C)C
InChI InChI=1S/C22H24O4S/c1-14-12-16(13-15(2)20(14)26-22(3,4)21(24)25)6-11-19(23)17-7-9-18(27-5)10-8-17/h6-13H,1-5H3,(H,24,25)/b11-6+
InChI Key AFLFKFHDSCQHOL-IZZDOVSWSA-N

Generated using the Chemistry Development Kit (CDK) (Willighagen EL et al. Journal of Cheminformatics vol. 9:33. 2017, doi:10.1186/s13321-017-0220-4; https://cdk.github.io/)

Classification Click here for help
Compound class Synthetic organic
Approved drug? Yes (EMA & FDA (2024))
Approved drug? Yes.
IUPAC Name Click here for help
2-[2,6-dimethyl-4-[(E)-3-(4-methylsulfanylphenyl)-3-oxoprop-1-enyl]phenoxy]-2-methylpropanoic acid
International Nonproprietary Names Click here for help
INN number INN
9973 elafibranor
Synonyms Click here for help
GFT-505 | GFT505 | Iqirvo®
Database Links Click here for help
CAS Registry No. 824932-88-9 (source: WHO INN record)
ChEMBL Ligand CHEMBL3707395
DrugBank Ligand DB05187
GtoPdb PubChem SID 434122195
PubChem CID 9864881
RCSB PDB Ligand MUO
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UniChem Compound Search for chemical match using the InChIKey AFLFKFHDSCQHOL-IZZDOVSWSA-N
UniChem Connectivity Search for chemical match using the InChIKey AFLFKFHDSCQHOL-IZZDOVSWSA-N

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MedChemExpress
Elafibranor (links to external site)
Cat. No. HY-16737