ChEMBL ligand: CHEMBL3707395 (Elafibranor, Gft505, GFT-505, GFT505)
NLRP3/NACHT, LRR and PYD domains-containing protein 3 in Mouse [ChEMBL: CHEMBL3779755] [GtoPdb: 1770] [UniProtKB: Q8R4B8] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181] There should be some charts here, you may need to enable JavaScript!
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
NLRP3/NACHT, LRR and PYD domains-containing protein 3 in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3779755] [GtoPdb: 1770] [UniProtKB: Q8R4B8]
ChEMBL	Inhibition of NLRP3 in mouse J774A.1 cells infected with FLA-ST assessed as inhibition of LPS- induced IL-1beta production by ELISA	B	4.4	pIC50	39600	nM	IC50	Eur J Med Chem (2021) 219: 113417-113417 [PMID:33845232]
Peroxisome proliferator-activated receptor-α/Peroxisome proliferator-activated receptor alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL239] [GtoPdb: 593] [UniProtKB: Q07869]
ChEMBL	Agonist activity at PPARalpha (unknown origin)	B	6.09	pEC50	820.3	nM	EC50	J Med Chem (2022) 65: 2571-2592 [PMID:35060744]
ChEMBL	Agonist activity at human Gal4 fused PPARalpha LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assay	B	6.12	pEC50	760	nM	EC50	Eur J Med Chem (2021) 218: 113388-113388 [PMID:33784603]
ChEMBL	Agonist activity at human PPARalpha transfected in human HepG2 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assay	B	6.43	pEC50	375	nM	EC50	Eur J Med Chem (2021) 225: 113807-113807 [PMID:34455359]
ChEMBL	Agonist activity at PPARalpha (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assay	B	6.65	pEC50	225	nM	EC50	ACS Med Chem Lett (2019) 10: 1068-1073 [PMID:31312410]
ChEMBL	Agonist activity at PPARalpha (unknown origin)	B	8	pEC50	10	nM	EC50	J Med Chem (2020) 63: 5031-5073 [PMID:31930920]
GtoPdb	-	-	8.22	pEC50	6	nM	EC50	Expert Opin Pharmacother (2014) 15: 493-503 [PMID:24428677]
Peroxisome proliferator-activated receptor-β/δ/Peroxisome proliferator-activated receptor delta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3979] [GtoPdb: 594] [UniProtKB: Q03181]
ChEMBL	Agonist activity at PPARdelta (unknown origin)	B	6.07	pEC50	842.9	nM	EC50	J Med Chem (2022) 65: 2571-2592 [PMID:35060744]
ChEMBL	Agonist activity at human Gal4 fused PPARdelta LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assay	B	6.14	pEC50	730	nM	EC50	Eur J Med Chem (2021) 218: 113388-113388 [PMID:33784603]
ChEMBL	Agonist activity at human PPARdelta transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assay	B	6.6	pEC50	249	nM	EC50	Eur J Med Chem (2021) 225: 113807-113807 [PMID:34455359]
ChEMBL	Agonist activity at PPARbeta (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assay	B	6.94	pEC50	115	nM	EC50	ACS Med Chem Lett (2019) 10: 1068-1073 [PMID:31312410]
ChEMBL	Agonist activity at PPARdelta (unknown origin)	B	8	pEC50	10	nM	EC50	J Med Chem (2020) 63: 5031-5073 [PMID:31930920]
Peroxisome proliferator-activated receptor-γ/Peroxisome proliferator-activated receptor gamma in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL235] [GtoPdb: 595] [UniProtKB: P37231]
ChEMBL	Agonist activity at human PPARgamma transfected in human HEK293 cells incubated for 18 hrs by Renilla/Firefly dual-luciferase reporter assay	B	5.4	pEC50	3962	nM	EC50	Eur J Med Chem (2021) 225: 113807-113807 [PMID:34455359]
ChEMBL	Agonist activity at human Gal4 fused PPARgamma LBD expressed in COS-7 cells incubated for 24 hrs by firefly luciferase reporter gene assay	B	5.55	pEC50	2790	nM	EC50	Eur J Med Chem (2021) 218: 113388-113388 [PMID:33784603]
ChEMBL	Agonist activity at PPARgamma (unknown origin) incubated for 3 to 16 hrs by pathhunter nuclear hormone receptor assay	B	5.67	pEC50	2116	nM	EC50	ACS Med Chem Lett (2019) 10: 1068-1073 [PMID:31312410]
ChEMBL	Agonist activity at PPARgamma (unknown origin)	B	5.73	pEC50	1843.8	nM	EC50	J Med Chem (2022) 65: 2571-2592 [PMID:35060744]
GtoPdb	-	-	7.33	pEC50	47	nM	EC50	Expert Opin Pharmacother (2014) 15: 493-503 [PMID:24428677]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]