tenidap   Click here for help

GtoPdb Ligand ID: 2395

PDB Ligand
Compound class: Synthetic organic
Comment: Tenidap is a dual COX/5-LOX inhibitor [4]. It was a clinical candidate with anti-inflammatory/anti-rheumatic potential, but development was terminated due to liver and kidney toxicity [1-2].
The INN record for tenidap provides the IUPAC name (Z)-5-chloro-3-(α-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide. The SMILES obtained by coverting this IUPAC using OPSIN match PubChem CID 60712, however this CID does not include the Z configuration that was specified in the INN's IUPAC name.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species

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2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 4
Hydrogen bond donors 2
Rotatable bonds 3
Topological polar surface area 113.56
Molecular weight 320.75
XLogP 3.2
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Clc1ccc2c(c1)c(C(=O)c1cccs1)c(n2C(=O)N)O
Isomeric SMILES c1csc(c1)C(=O)c1c(n(c2c1cc(cc2)Cl)C(=O)N)O
InChI InChI=1S/C14H9ClN2O3S/c15-7-3-4-9-8(6-7)11(13(19)17(9)14(16)20)12(18)10-2-1-5-21-10/h1-6,19H,(H2,16,20)
InChI Key IZSFDUMVCVVWKW-UHFFFAOYSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
5-chloro-2-hydroxy-3-(thiophene-2-carbonyl)indole-1-carboxamide
International Nonproprietary Names Click here for help
INN number INN
6421 tenidap
Database Links Click here for help
CAS Registry No. 120210-48-2 (source: Scifinder)
ChEBI CHEBI:35847
ChEMBL Ligand CHEMBL1908355
DrugCentral Ligand 4728
GtoPdb PubChem SID 135651243
PubChem CID 60712
RCSB PDB Ligand I2U
Search Google for chemical match using the InChIKey IZSFDUMVCVVWKW-UHFFFAOYSA-N
Search Google for chemicals with the same backbone IZSFDUMVCVVWKW
Search PubMed clinical trials tenidap
Search PubMed titles tenidap
Search PubMed titles/abstracts tenidap
UniChem Compound Search for chemical match using the InChIKey IZSFDUMVCVVWKW-UHFFFAOYSA-N
UniChem Connectivity Search for chemical match using the InChIKey IZSFDUMVCVVWKW-UHFFFAOYSA-N
Wikipedia Tenidap

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Tocris
Tenidap (links to external site)
Cat. No. 2580