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Compound class: Synthetic organic
Comment: Tenidap is a dual COX/5-LOX inhibitor . It was a clinical candidate with anti-inflammatory/anti-rheumatic potential, but development was terminated due to liver and kidney toxicity [1-2].
The INN record for tenidap provides the IUPAC name (Z)-5-chloro-3-(α-hydroxy-2-thenylidene)-2-oxo-1-indolinecarboxamide. The SMILES obtained by coverting this IUPAC using OPSIN match PubChem CID 60712, however this CID does not include the Z configuration that was specified in the INN's IUPAC name.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|International Nonproprietary Names|
|CAS Registry No.||120210-48-2 (source: Scifinder)|
|GtoPdb PubChem SID||135651243|
|Search Google for chemical match using the InChIKey||IZSFDUMVCVVWKW-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||IZSFDUMVCVVWKW|
|Search PubMed clinical trials||tenidap|
|Search PubMed titles||tenidap|
|Search PubMed titles/abstracts||tenidap|
|UniChem Compound Search for chemical match using the InChIKey||IZSFDUMVCVVWKW-UHFFFAOYSA-N|
|UniChem Connectivity Search for chemical match using the InChIKey||IZSFDUMVCVVWKW-UHFFFAOYSA-N|
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Tenidap (links to external site)
Cat. No. 2580