naltriben [Ligand Id: 1640] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL100940 (Naltriben) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
| GtoPdb | - | - | 10 | pKi | 0.1 | nM | Ki |
NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]; J Pharmacol Exp Ther (1991) 257: 676-80 [PMID:1851833] |
| ChEMBL | Compound was evaluated for binding affinity at Opioid receptor delta 1 in guinea pig brain membranes | B | 10.89 | pKi | 0.01 | nM | Ki | J Med Chem (1991) 34: 1757-1762 [PMID:1648136] |
| δ receptor in Mouse [GtoPdb: 317] [UniProtKB: P32300] | ||||||||
| GtoPdb | - | - | 10.9 | pKi | - | - | - | Mol Pharmacol (1994) 45: 330-4 [PMID:8114680] |
| δ receptor in Rat [GtoPdb: 317] [UniProtKB: P33533] | ||||||||
| GtoPdb | - | - | 10 | pKi | - | - | - | Br J Pharmacol (1999) 128: 556-62 [PMID:10516632] |
| Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144] | ||||||||
| ChEMBL | Compound was evaluated for binding affinity of Opioid receptor kappa 1 in guinea pig brain membranes | B | 6.82 | pKi | 152 | nM | Ki | J Med Chem (1991) 34: 1757-1762 [PMID:1648136] |
| Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266] | ||||||||
| ChEMBL | Compound was evaluated for binding affinity at Opioid receptor mu 1 in guinea pig brain membranes | B | 7.72 | pKi | 19 | nM | Ki | J Med Chem (1991) 34: 1757-1762 [PMID:1648136] |
| κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
| GtoPdb | - | - | 8.4 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
| μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
| GtoPdb | - | - | 7.9 | pKi | - | - | - | NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
