naltriben [Ligand Id: 1640] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL100940 (Naltriben)
  • δ receptor/Delta opioid receptor in Human [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
  • δ receptor in Mouse [GtoPdb: 317] [UniProtKB: P32300]
  • δ receptor in Rat [GtoPdb: 317] [UniProtKB: P33533]
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  • κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
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  • μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143]
GtoPdb - - 10 pKi 0.1 nM Ki NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407];
J Pharmacol Exp Ther (1991) 257: 676-80 [PMID:1851833]
ChEMBL Compound was evaluated for binding affinity at Opioid receptor delta 1 in guinea pig brain membranes B 10.89 pKi 0.01 nM Ki J. Med. Chem. (1991) 34: 1757-1762 [PMID:1648136]
δ receptor in Mouse [GtoPdb: 317] [UniProtKB: P32300]
GtoPdb - - 10.9 pKi - - - Mol Pharmacol (1994) 45: 330-4 [PMID:8114680]
δ receptor in Rat [GtoPdb: 317] [UniProtKB: P33533]
GtoPdb - - 10 pKi - - - Br J Pharmacol (1999) 128: 556-62 [PMID:10516632]
Kappa opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3952] [UniProtKB: P41144]
ChEMBL Compound was evaluated for binding affinity of Opioid receptor kappa 1 in guinea pig brain membranes B 6.82 pKi 152 nM Ki J. Med. Chem. (1991) 34: 1757-1762 [PMID:1648136]
Mu opioid receptor in Guinea pig (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4354] [UniProtKB: P97266]
ChEMBL Compound was evaluated for binding affinity at Opioid receptor mu 1 in guinea pig brain membranes B 7.72 pKi 19 nM Ki J. Med. Chem. (1991) 34: 1757-1762 [PMID:1648136]
κ receptor in Human [GtoPdb: 318] [UniProtKB: P41145]
GtoPdb - - 8.4 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]
μ receptor in Human [GtoPdb: 319] [UniProtKB: P35372]
GtoPdb - - 7.9 pKi - - - NIDA Res Monogr (1998) 178: 440-66 [PMID:9686407]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]