AGL 2043 [Ligand Id: 5918] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2218927 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| epidermal growth factor receptor/Epidermal growth factor receptor erbB1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL203] [GtoPdb: 1797] [UniProtKB: P00533] | ||||||||
| ChEMBL | Inhibition of EGFR in human A431 cells incubated for 2 hrs followed by EGF stimulation and measured after 10 mins by immunoblot assay | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem (2019) 27: 16-35 [PMID:30502116] |
| Insulin-like growth factor I receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1957] [GtoPdb: 1801] [UniProtKB: P08069] | ||||||||
| ChEMBL | Inhibition of IGFR1 (unknown origin) using poly (Glu,Tyr) 4:1 as substrate | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem (2019) 27: 16-35 [PMID:30502116] |
| platelet derived growth factor receptor beta/Platelet-derived growth factor receptor beta in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1913] [GtoPdb: 1804] [UniProtKB: P09619] | ||||||||
| ChEMBL | Inhibition of human PDGFR beta | B | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem (2019) 27: 16-35 [PMID:30502116] |
| GtoPdb | Using purified human PDGFRβ | - | 7.05 | pIC50 | 90 | nM | IC50 | Bioorg Med Chem (2003) 11: 2007-18 [PMID:12670652] |
| KIT proto-oncogene, receptor tyrosine kinase/Stem cell growth factor receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1936] [GtoPdb: 1805] [UniProtKB: P10721] | ||||||||
| ChEMBL | Inhibition of c-KIT in human M-07e cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by KIT ligand stimulation by immunoblotting analysis | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2019) 27: 16-35 [PMID:30502116] |
| fms related receptor tyrosine kinase 3/Tyrosine-protein kinase receptor FLT3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1974] [GtoPdb: 1807] [UniProtKB: P36888] | ||||||||
| ChEMBL | Inhibition of human FLT3 expressed in mouse BAF3 cells assessed as reduction in tyrphostin activity incubated for 2 hrs followed by FLT3 ligand stimulation by immunoblot analysis | B | 6 | pIC50 | 1000 | nM | IC50 | Bioorg Med Chem (2019) 27: 16-35 [PMID:30502116] |
| SRC proto-oncogene, non-receptor tyrosine kinase/Tyrosine-protein kinase SRC in Mouse (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3074] [GtoPdb: 2206] [UniProtKB: P05480] | ||||||||
| ChEMBL | Inhibition of SRC in transformed mouse NIH3T3 cells by SDS-PAGE based immunoblot assay | B | 4.52 | pIC50 | >30000 | nM | IC50 | Bioorg Med Chem (2019) 27: 16-35 [PMID:30502116] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
