compound 26 [PMID: 21733693] [Ligand Id: 8783] activity data from GtoPdb and ChEMBL
Click here for a description of the charts and data table
Please tell us if you are using this feature and what you think!
| ChEMBL ligand: CHEMBL1808264 |
|---|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
There should be some charts here, you may need to enable JavaScript!
|
| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| activin A receptor type 2B/Activin receptor type-2B in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5466] [GtoPdb: 1792] [UniProtKB: Q13705] | ||||||||
| ChEMBL | Inhibition of ACTR-2B | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4436-4440 [PMID:21733693] |
| nuclear receptor coactivator 1/Nuclear receptor coactivator 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1615387] [GtoPdb: 2693] [UniProtKB: Q15788] | ||||||||
| GtoPdb | - | - | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4436-40 [PMID:21733693] |
| ChEMBL | Inhibition of Src1 | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4436-4440 [PMID:21733693] |
| erb-b2 receptor tyrosine kinase 4/Receptor protein-tyrosine kinase erbB-4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3009] [GtoPdb: 1799] [UniProtKB: Q15303] | ||||||||
| ChEMBL | Inhibition of ErbB4 | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4436-4440 [PMID:21733693] |
| B-Raf proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase B-raf in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5145] [GtoPdb: 1943] [UniProtKB: P15056] | ||||||||
| ChEMBL | Inhibition of B-Raf V600E mutant (unknown origin) using fluorescein-MAP2K1 as substrate after 1 hr by electrophoretic assay | B | 8.42 | pIC50 | 3.8 | nM | IC50 | Medchemcomm (2017) 8: 1835-1844 [PMID:30108894] |
| ChEMBL | Inhibition of B-Raf V600E mutant | B | 8.42 | pIC50 | 3.8 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4436-4440 [PMID:21733693] |
| ChEMBL | Inhibition of B-Raf V600E mutant (unknown origin) using fluorescein-MAP2K1 as substrate after 1 hr by electrophoretic assay | B | 8.42 | pIC50 | 3.8 | nM | IC50 | Medchemcomm (2017) 8: 1835-1844 [PMID:30108894] |
| ChEMBL | Inhibition of B-Raf V600E mutant in human SK-MEL-28 cells assessed as reduction of ERK phosphorylation after 1 hr | B | 7.64 | pEC50 | 23 | nM | EC50 | Bioorg Med Chem Lett (2011) 21: 4436-4440 [PMID:21733693] |
| transforming growth factor beta receptor 1/TGF-beta receptor type I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4439] [GtoPdb: 1788] [UniProtKB: P36897] | ||||||||
| ChEMBL | Inhibition of ALK5 | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4436-4440 [PMID:21733693] |
| Bruton tyrosine kinase/Tyrosine-protein kinase BTK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5251] [GtoPdb: 1948] [UniProtKB: Q06187] | ||||||||
| ChEMBL | Inhibition of Btk | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4436-4440 [PMID:21733693] |
| LCK proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase LCK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL258] [GtoPdb: 2053] [UniProtKB: P06239] | ||||||||
| ChEMBL | Inhibition of Lck | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4436-4440 [PMID:21733693] |
| LYN proto-oncogene, Src family tyrosine kinase/Tyrosine-protein kinase Lyn in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3905] [GtoPdb: 2060] [UniProtKB: P07948] | ||||||||
| ChEMBL | Inhibition of Lyn | B | 8 | pIC50 | 10 | nM | IC50 | Bioorg Med Chem Lett (2011) 21: 4436-4440 [PMID:21733693] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
