retigabine derivative 10g [Ligand Id: 11479] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL4588394 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696] | ||||||||
| GtoPdb | - | - | 6 | pEC50 | - | - | - | ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942] |
| ChEMBL | Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assay | B | 6.11 | pEC50 | 780 | nM | EC50 | ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942] |
| Kv7.5/Voltage-gated potassium channel subunit Kv7.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2925] [GtoPdb: 564] [UniProtKB: Q9NR82] | ||||||||
| ChEMBL | Agonist activity at human KCNQ5 expressed in CHOK1 cells by whole cell patch clamp assay | B | 5.77 | pEC50 | 1680 | nM | EC50 | ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942] |
| GtoPdb | - | - | 6 | pEC50 | - | - | - | ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
