retigabine derivative 10g [Ligand Id: 11479] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL4588394
  • Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
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  • Kv7.5/Voltage-gated potassium channel subunit Kv7.5 in Human [ChEMBL: CHEMBL2925] [GtoPdb: 564] [UniProtKB: Q9NR82]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Kv7.4/Voltage-gated potassium channel subunit Kv7.4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3576] [GtoPdb: 563] [UniProtKB: P56696]
GtoPdb - - 6 pEC50 - - - ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942]
ChEMBL Agonist activity at human KCNQ4 expressed in CHOK1 cells by whole cell patch clamp assay B 6.11 pEC50 780 nM EC50 ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942]
Kv7.5/Voltage-gated potassium channel subunit Kv7.5 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2925] [GtoPdb: 564] [UniProtKB: Q9NR82]
ChEMBL Agonist activity at human KCNQ5 expressed in CHOK1 cells by whole cell patch clamp assay B 5.77 pEC50 1680 nM EC50 ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942]
GtoPdb - - 6 pEC50 - - - ACS Med Chem Lett (2019) 10: 27-33 [PMID:30655942]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]