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ChEMBL ligand: CHEMBL6206 (Bromoenol Lactone, BTNP) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519] | ||||||||
ChEMBL | Irreversible inhibition of fatty acid amide hydrolase | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2005) 48: 5059-5087 [PMID:16078824] |
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612] | ||||||||
ChEMBL | Inhibition of FAAH in rat brain assessed as hydrolysis of anandamide | B | 6.1 | pIC50 | 800 | nM | IC50 | J Med Chem (2008) 51: 7327-7343 [PMID:18983142] |
iPLA2-G6/Calcium-independent phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3213] [GtoPdb: 1431] [UniProtKB: O60733] | ||||||||
ChEMBL | Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2. | B | 6.85 | pIC50 | 140 | nM | IC50 | J Med Chem (1993) 36: 95-100 [PMID:8421294] |
ChEMBL | Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2. | B | 7 | pIC50 | >100 | nM | IC50 | J Med Chem (1993) 36: 95-100 [PMID:8421294] |
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364] | ||||||||
ChEMBL | Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay | F | 4.8 | pIC50 | 15848.93 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
ChEMBL | Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay | F | 5 | pIC50 | 10000 | nM | IC50 | Nat Chem Biol (2009) 5: 765-771 [PMID:19734910] |
TRPC5 in Mouse [GtoPdb: 490] [UniProtKB: Q9QX29] | ||||||||
GtoPdb | - | - | 4.97 | pIC50 | - | - | - | J Pharmacol Exp Ther (2011) 339: 329-40 [PMID:21795434] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]