bromoenol lactone [Ligand Id: 5149] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL6206 (BTNP, Bromoenol Lactone)
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Human [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
  • Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
There should be some charts here, you may need to enable JavaScript!
  • iPLA2-G6/Calcium-independent phospholipase A2 in Human [ChEMBL: CHEMBL3213] [GtoPdb: 1431] [UniProtKB: O60733]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • TRPC5 in Mouse [GtoPdb: 490] [UniProtKB: Q9QX29]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Fatty acid amide hydrolase/Anandamide amidohydrolase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2243] [GtoPdb: 1400] [UniProtKB: O00519]
ChEMBL Irreversible inhibition of fatty acid amide hydrolase B 6.1 pIC50 800 nM IC50 J. Med. Chem. (2005) 48: 5059-5087 [PMID:16078824]
Fatty acid amide hydrolase/Anandamide amidohydrolase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3229] [GtoPdb: 1400] [UniProtKB: P97612]
ChEMBL Inhibition of FAAH in rat brain assessed as hydrolysis of anandamide B 6.1 pIC50 800 nM IC50 J. Med. Chem. (2008) 51: 7327-7343 [PMID:18983142]
iPLA2-G6/Calcium-independent phospholipase A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3213] [GtoPdb: 1431] [UniProtKB: O60733]
ChEMBL Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2. B 6.85 pIC50 140 nM IC50 J. Med. Chem. (1993) 36: 95-100 [PMID:8421294]
ChEMBL Compounds were evaluated for the inhibitory activity against canine myocardial cytosolic calcium dependent phospholipase A2. B 7 pIC50 >100 nM IC50 J. Med. Chem. (1993) 36: 95-100 [PMID:8421294]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay F 4.8 pIC50 15848.93 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
TRPC5 in Mouse [GtoPdb: 490] [UniProtKB: Q9QX29]
GtoPdb - - 4.97 pIC50 - - - J Pharmacol Exp Ther (2011) 339: 329-40 [PMID:21795434]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]