bekanamycin [Ligand Id: 12182] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL176 (Aminodeoxykanamycin, Bekanamicina, Bekanamycin, Bekanamycine, Bekanamycin sulfate, Kanamycin b, Kantrex, Klebcil, Nebramycin v, NK 1006, NK-1006) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| 3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1795135] [UniProtKB: C3TDZ2] | ||||||||
| ChEMBL | Inhibition of Escherichia coli FabH overexpressed in Escherichia coli DH10B cells assessed as incorporation of [3H] in the product after 25 mins by liquid scintillation counting analysis | B | 5.2 | pIC50 | 6300 | nM | IC50 | Bioorg Med Chem Lett (2014) 24: 90-95 [PMID:24332628] |
| 3-oxoacyl-[acyl-carrier-protein] synthase 3 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4914] [UniProtKB: P0A6R0] | ||||||||
| ChEMBL | Inhibition of Escherichia coli FabH expressed in Escherichia coli DH10B using holo-ACP/acetyl-CoA as substrate assessed as incorporation of [3H] signal in final product preincubated with holo-ACP for 1 hr followed by acetyl-CoA addition measured after 25 mins by liquid scintillation counting method | B | 5.25 | pIC50 | 5600 | nM | IC50 | Medchemcomm (2016) 7: 1980-1987 |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
