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ChEMBL ligand: CHEMBL67166 (D-Sphingosine) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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protein kinase, cAMP-dependent, catalytic, alpha subunit/cAMP-dependent protein kinase alpha-catalytic subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3390] [GtoPdb: 1476] [UniProtKB: P27791] | ||||||||
ChEMBL | Inhibition of cAMP-dependent kinase PKA(Protein kinase A) catalytic subunit at 100 uM | B | 7.01 | pIC50 | 98 | nM | IC50 | J Med Chem (1991) 34: 2928-2931 [PMID:1895309] |
cholesteryl ester transfer protein/Cholesteryl ester transfer protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3572] [GtoPdb: 3248] [UniProtKB: P11597] | ||||||||
ChEMBL | Compound was measured for its inhibitory activity against cholesteryl ester transfer protein (CETP) | B | 4.94 | pIC50 | 11500 | nM | IC50 | Bioorg Med Chem Lett (1997) 7: 1481-1482 |
sphingosine kinase 1/Sphingosine kinase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4394] [GtoPdb: 2204] [UniProtKB: Q9NYA1] | ||||||||
ChEMBL | Inhibition of SphK1 | B | 5.41 | pIC50 | 3860 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3382-3385 [PMID:19467599] |
sphingosine kinase 2/Sphingosine kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3023] [GtoPdb: 2205] [UniProtKB: Q9NRA0] | ||||||||
ChEMBL | Inhibition of SphK2 | B | 5.81 | pIC50 | 1560 | nM | IC50 | Bioorg Med Chem Lett (2009) 19: 3382-3385 [PMID:19467599] |
TRPM3 in Human [GtoPdb: 495] [UniProtKB: Q9HCF6] | ||||||||
GtoPdb | - | - | 4.9 | pEC50 | 12589 | nM | EC50 | Mol Pharmacol (2005) 67: 798-805 [PMID:15550678] |
TRPM7 in Mouse [GtoPdb: 499] [UniProtKB: Q923J1] | ||||||||
GtoPdb | - | - | 6.23 | pIC50 | 590 | nM | IC50 | Br J Pharmacol (2013) 168: 1294-312 [PMID:23145923] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]