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Compound class:
Synthetic organic
Comment: NX-2127 is an orally bioavailable protein degrader molecule. It reduces levels of both Bruton's tyrosine kinase (BTK) and the IKZF transcription factors Ikaros (IKZF1) and Aiolos (IKZF3) through targeted ubiquitination and proteasomal degradation. NX-2127 acts as a dual PROTAC (through recruitment of cereblon) and molecular glue (degradation of the neosubstrate transcription factors). It is predicted that this approach can achieve clinical efficacy, even in the presence of BTK mutations that confer resistance to clinically used kinase inhibitor drugs.
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Classification ![]() |
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Compound class | Synthetic organic |
Ligand families/groups | PROTACs, molecular glues and other degraders |
IUPAC Name ![]() |
3-[4-[1-[[(3R)-1-[2-(2,6-dioxopiperidin-3-yl)-1,3-dioxoisoindol-5-yl]pyrrolidin-3-yl]methyl]piperidin-4-yl]anilino]-5-piperidin-1-ylpyrazine-2-carboxamide |
Database Links ![]() |
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GtoPdb PubChem SID | 479821309 |
PubChem CID | 167282486 |
Search Google for chemical match using the InChIKey | XLWJWCMQMBVNSG-LZDHLTRGSA-N |
Search Google for chemicals with the same backbone | XLWJWCMQMBVNSG |
UniChem Compound Search for chemical match using the InChIKey | XLWJWCMQMBVNSG-LZDHLTRGSA-N |
UniChem Connectivity Search for chemical match using the InChIKey | XLWJWCMQMBVNSG-LZDHLTRGSA-N |