BMS-986158   Click here for help

GtoPdb Ligand ID: 11757

Synonyms: BMS986158 | compound 18 [PMID: 34543572]
PDB Ligand
Compound class: Synthetic organic
Comment: BMS-986158 is a clinical candidate inhibitor of bromodomain and extra-terminal (BET) domain-containing proteins [3]. It was developed as a potential treatment for haematologic and solid tumours. Early pan-BET inhibitors include (+)-JQ1 and molibresib (GSK525762), but some tumours are either inherently resistant to these inhibitors [4], or develop treatment-induced resistance [1]. BMS-986158 was designed on a different chemical scaffold to combat resistance issues.
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Ligand Activity Visualisation Charts

These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.

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View interactive charts of activity data across species
2D Structure
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2D Structure

An image of the ligand's 2D structure. For small molecules with SMILES these are drawn using the NCI/CADD Chemical Identifier Resolver. Click on the image to access the chemical structure search tool with the ligand pre-loaded in the structure editor. For other types of ligands, e.g. longer nucleotides and peptides, a manually drawn representation of the molecule may be provided.

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Physico-chemical Properties
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Physico-chemical Properties

Calculated molecular properties are available for small molecules and natural products (not peptides). Properties were generated using the CDK toolkit. All properties were selected to enable the prediction of the Lipinski Rule-of-Five profile or ‘druglikeness’ for each ligand. For more info on each category see the help pages.

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Hydrogen bond acceptors 5
Hydrogen bond donors 1
Rotatable bonds 5
Topological polar surface area 77.99
Molecular weight 495.26
XLogP 4.99
No. Lipinski's rules broken 0
SMILES / InChI / InChIKey
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SMILES / InChI / InChIKey

SMILES (Simplified Molecular Input Line Entry Specification) A specification for unambiguously describing the structure of chemical molecules using short ASCII strings. Canonical SMILES specify a unique representation of the 2D structure without chiral or isotopic specifications. Isomeric SMILES include chiral specification and isotopes.

Standard InChI (IUPAC International Chemical Identifier) and InChIKey InChI is a non-proprietary, standard, textual identifier for chemical substances designed to facilitate linking of information and database searching. An InChIKey is a simplified version of a full InChI, designed for easier web searching.

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Canonical SMILES Cc1nnn(c1c1cnc2c(c1)n([C@H](c1ccccc1)C1CCOCC1)c1c2ccc(c1)C(O)(C)C)C
Isomeric SMILES Cn1nnc(C)c1c1cnc2c(c1)n([C@@H](C1CCOCC1)c1ccccc1)c1c2ccc(c1)C(C)(C)O
InChI InChI=1S/C30H33N5O2/c1-19-28(34(4)33-32-19)22-16-26-27(31-18-22)24-11-10-23(30(2,3)36)17-25(24)35(26)29(20-8-6-5-7-9-20)21-12-14-37-15-13-21/h5-11,16-18,21,29,36H,12-15H2,1-4H3/t29-/m1/s1
InChI Key KGERZPVQIRYWRK-GDLZYMKVSA-N
Classification Click here for help
Compound class Synthetic organic
IUPAC Name Click here for help
2-[3-(3,5-dimethyltriazol-4-yl)-5-[(S)-oxan-4-yl(phenyl)methyl]pyrido[3,2-b]indol-7-yl]propan-2-ol
Synonyms Click here for help
BMS986158 | compound 18 [PMID: 34543572]
Database Links Click here for help
CAS Registry No. 1800340-40-2 (source: PubChem)
ChEMBL Ligand CHEMBL4297458
DrugBank Ligand DB15435
GtoPdb PubChem SID 458923792
PubChem CID 118196485
RCSB PDB Ligand YWA
Search Google for chemical match using the InChIKey KGERZPVQIRYWRK-GDLZYMKVSA-N
Search Google for chemicals with the same backbone KGERZPVQIRYWRK
UniChem Compound Search for chemical match using the InChIKey KGERZPVQIRYWRK-GDLZYMKVSA-N
UniChem Connectivity Search for chemical match using the InChIKey KGERZPVQIRYWRK-GDLZYMKVSA-N