ChEMBL ligand: CHEMBL709 (Alfuzosin, NSC-760065, Uroxatral)
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] There should be some charts here, you may need to enable JavaScript!
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348] Alpha-1a adrenergic receptor in Bovine [ChEMBL: CHEMBL4892] [UniProtKB: P18130] α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140] There should be some charts here, you may need to enable JavaScript!
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368] α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823] There should be some charts here, you may need to enable JavaScript!
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100] α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Organic cation transporter 1/Solute carrier family 22 member 1 in Human [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Inhibition of AChE (unknown origin)	B	7.74	pIC50	18	nM	IC50	Bioorg Med Chem (2018) 26: 1511-1522 [PMID:29429576]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL229] [GtoPdb: 22] [UniProtKB: P35348]
ChEMBL	In vitro antagonistic activity against alpha-1A receptor in dog prostate.	F	6.66	pKd	218.78	nM	Kd	J Med Chem (2001) 44: 1971-1985 [PMID:11384242]
ChEMBL	Binding affinity was tested on human Alpha-1A adrenergic receptor	B	8	pKi	10	nM	Ki	J Med Chem (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL	Binding affinity against Alpha-1A adrenergic receptor from human clone	B	8.09	pKi	8.2	nM	Ki	J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
GtoPdb	-	-	8.1	pKi	8.2	nM	Ki	Pharm Acta Helv (2000) 74: 163-71 [PMID:10812954]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
Alpha-1a adrenergic receptor in Bovine (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4892] [UniProtKB: P18130]
ChEMBL	Binding affinity against Alpha-1A adrenergic receptor from bovine clone	B	7.64	pKi	23	nM	Ki	J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
α1A-adrenoceptor/Alpha-1a adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL319] [GtoPdb: 22] [UniProtKB: P43140]
ChEMBL	In vitro antagonistic activity towards alpha-1A adrenergic receptor in rat vas deferens	F	7.61	pKd	24.55	nM	Kd	J Med Chem (2001) 44: 1971-1985 [PMID:11384242]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL232] [GtoPdb: 23] [UniProtKB: P35368]
ChEMBL	Binding affinity against Alpha-1B adrenergic receptor from hamster clones.	B	7.92	pKi	12	nM	Ki	J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
ChEMBL	Binding affinity was tested on human Alpha-1B adrenergic receptor	B	8	pKi	10	nM	Ki	J Med Chem (1997) 40: 1293-1315 [PMID:9135028]
ChEMBL	Binding affinity against Alpha-1B adrenergic receptor from human clone	B	8.55	pKi	2.8	nM	Ki	J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
GtoPdb	-	-	8.6	pKi	2.8	nM	Ki	J Med Chem (1995) 38: 3415-44 [PMID:7658428]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
α1B-adrenoceptor/Alpha-1b adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL315] [GtoPdb: 23] [UniProtKB: P15823]
ChEMBL	In vitro antagonistic activity against alpha-1B receptor in rat spleen.	F	8.31	pKd	4.9	nM	Kd	J Med Chem (2001) 44: 1971-1985 [PMID:11384242]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL223] [GtoPdb: 24] [UniProtKB: P25100]
GtoPdb	-	-	8.4	pKi	-	-	-	Pharm Acta Helv (2000) 74: 163-71 [PMID:10812954]; Pharmacol Res Perspect (2020) 8: e00602 [PMID:32608144]
ChEMBL	Binding affinity against Alpha-1D adrenergic receptor, from human clones.	B	8.44	pKi	3.6	nM	Ki	J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
ChEMBL	Binding affinity was tested on human Alpha-1D adrenergic receptor	B	8.5	pKi	3.16	nM	Ki	J Med Chem (1997) 40: 1293-1315 [PMID:9135028]
α1D-adrenoceptor/Alpha-1d adrenergic receptor in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL326] [GtoPdb: 24] [UniProtKB: P23944]
ChEMBL	Binding affinity against Alpha-1D adrenergic receptor, from rat clones.	B	8.46	pKi	3.5	nM	Ki	J Med Chem (1995) 38: 3415-3444 [PMID:7658428]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) K1 cells stably expressing hERG measured using IonWorks Quattro automated patch clamp platform	F	4.7	pIC50	19952.62	nM	IC50	J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]
ChEMBL	Inhibition of rapid delayed inward rectifying potassium current (IKr) in Chinese hamster ovary (CHO) cells stable expressing hERG measured using IonWorks Barracuda automated patch clamp platform	F	4.9	pIC50	12589.25	nM	IC50	J Pharmacol Toxicol Methods (2014) 70: 246-254 [PMID:25087753]
Organic cation transporter 1/Solute carrier family 22 member 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5685] [GtoPdb: 1019] [UniProtKB: O15245]
ChEMBL	Inhibition of human OCT1 expressed in HEK293 cells assessed as decrease in uptake of ASP+ after 2 mins by fluorescence assay	B	4.83	pIC50	14870	nM	IC50	J Med Chem (2017) 60: 2685-2696 [PMID:28230985]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]