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Synonyms: AG-014699 | AG014699 | AG14447 | PF-01367338 | Rubraca®
rucaparib is an approved drug (FDA (2016), EMA (2018))
Compound class: Synthetic organic
Comment: Rucaparib is an orally active poly(ADP-ribose)polymerase (PARP) inhibitor with anti-cancer activity . It was developed by Clovis Oncology.
PARP inhibitors are known to enhance efficacy of anti-cancer therapies such as DNA alkylating agents, topoisomerase I poisons, and ionizing radiation.
Note that in the Thomas et al. paper , AG014699 refers to the phosphate salt and AG14447 to the parent molecule.
Rucaparib was accepted for FDA priority review for the treatment of advanced ovarian cancer harbouring mutant BRCA (August 2016).
Note: olaparib was the first PARP inhibitor to be approved for clinical use.
Ligand Activity Visualisation Charts
These are box plot that provide a unique visualisation, summarising all the activity data for a ligand taken from ChEMBL and GtoPdb across multiple targets and species. Click on a plot to see the median, interquartile range, low and high data points. A value of zero indicates that no data are available. A separate chart is created for each target, and where possible the algorithm tries to merge ChEMBL and GtoPdb targets by matching them on name and UniProt accession, for each available species. However, please note that inconsistency in naming of targets may lead to data for the same target being reported across multiple charts.✖
|Compound class||Synthetic organic|
|Approved drug?||Yes (FDA (2016), EMA (2018))|
|International Nonproprietary Names|
|AG-014699 | AG014699 | AG14447 | PF-01367338 | Rubraca®|
|CAS Registry No.||283173-50-2|
|GtoPdb PubChem SID||223366069|
|RCSB PDB Ligand||RPB|
|Search Google for chemical match using the InChIKey||HMABYWSNWIZPAG-UHFFFAOYSA-N|
|Search Google for chemicals with the same backbone||HMABYWSNWIZPAG|
|Search PubMed clinical trials||rucaparib|
|Search PubMed titles||rucaparib|
|Search PubMed titles/abstracts||rucaparib|
|Search UniChem for chemical match using the InChIKey||HMABYWSNWIZPAG-UHFFFAOYSA-N|
|Search UniChem for chemicals with the same backbone||HMABYWSNWIZPAG|
|SynPHARM||80263 (in complex with poly(ADP-ribose) polymerase 1)|