ChEMBL ligand: CHEMBL1173055 (Rucaparib, AG-014699, AG-14447)
poly(ADP-ribose) polymerase 1/Poly [ADP-ribose] polymerase-1 in Human [ChEMBL: CHEMBL3105] [GtoPdb: 2771] [UniProtKB: P09874] There should be some charts here, you may need to enable JavaScript!
Poly [ADP-ribose] polymerase 10 in Human [ChEMBL: CHEMBL2429708] [UniProtKB: Q53GL7] There should be some charts here, you may need to enable JavaScript!
Poly [ADP-ribose] polymerase 12 in Human [ChEMBL: CHEMBL2429709] [UniProtKB: Q9H0J9] There should be some charts here, you may need to enable JavaScript!
Poly [ADP-ribose] polymerase 14 in Human [ChEMBL: CHEMBL2176777] [UniProtKB: Q460N5] There should be some charts here, you may need to enable JavaScript!
Poly [ADP-ribose] polymerase 15 in Human [ChEMBL: CHEMBL2176778] [UniProtKB: Q460N3] There should be some charts here, you may need to enable JavaScript!
poly(ADP-ribose) polymerase 2/Poly [ADP-ribose] polymerase 2 in Human [ChEMBL: CHEMBL5366] [GtoPdb: 2772] [UniProtKB: Q9UGN5] There should be some charts here, you may need to enable JavaScript!
poly (ADP-ribose) polymerase 3/Poly [ADP-ribose] polymerase 3 in Human [ChEMBL: CHEMBL5083] [GtoPdb: 2864] [UniProtKB: Q9Y6F1] There should be some charts here, you may need to enable JavaScript!
Poly [ADP-ribose] polymerase 4 in Human [ChEMBL: CHEMBL6142] [UniProtKB: Q9UKK3] There should be some charts here, you may need to enable JavaScript!
tankyrase/Tankyrase-1 in Human [ChEMBL: CHEMBL6164] [GtoPdb: 3108] [UniProtKB: O95271] There should be some charts here, you may need to enable JavaScript!
tankyrase 2/Tankyrase-2 in Human [ChEMBL: CHEMBL6154] [GtoPdb: 3109] [UniProtKB: Q9H2K2] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
poly(ADP-ribose) polymerase 1/Poly [ADP-ribose] polymerase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3105] [GtoPdb: 2771] [UniProtKB: P09874]
GtoPdb	-	-	8.85	pKi	1.4	nM	Ki	Mol Cancer Ther (2007) 6: 945-56 [PMID:17363489]
ChEMBL	Inhibition of human full-length recombinant ARTD1 assessed as incorporation of [32P]NAD+ by scintillation counting analysis	B	8.85	pKi	1.4	nM	Ki	ACS Med. Chem. Lett. (2014) 5: 18-22 [PMID:24900770]
ChEMBL	Inhibition of PARP1 (unknown origin)	B	8.85	pKi	1.4	nM	Ki	Bioorg Med Chem Lett (2016) 26: 4127-4132 [PMID:27353531]
ChEMBL	Inhibition of human recombinant full-length PARP1 after 4 mins by [32P]NAD+ incorporation assay	B	8.85	pKi	1.4	nM	Ki	Eur J Med Chem (2019) 165: 198-215 [PMID:30684797]
ChEMBL	Inhibition of PARP1 (unknown origin)	B	6.3	pIC50	>500	nM	IC50	J. Med. Chem. (2015) 58: 3302-3314 [PMID:25761096]
ChEMBL	Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.52	pIC50	302	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human His6-tagged PARP1 C-3-zinc finger domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.52	pIC50	301	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	7.4	pIC50	39.81	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human His6-tagged PARP1 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	7.4	pIC50	39.8	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human GST-tagged PARP1 expressed in Escherichia coli using damaged DNA as substrate after 30 mins in presence of NAD+ by resazurin dye based fluorescence assay	B	7.59	pIC50	26	nM	IC50	Bioorg Med Chem Lett (2018) 28: 847-852 [PMID:29456106]
ChEMBL	Inhibition of human recombinant full-length PARP1 after 4 mins by [32P]NAD+ incorporation assay	B	8.33	pIC50	4.7	nM	IC50	Eur J Med Chem (2019) 165: 198-215 [PMID:30684797]
ChEMBL	Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	8.49	pIC50	3.2	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of full length recombinant human His6-tagged PARP1 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	8.5	pIC50	3.16	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of human PARP1 using [3H]NAD as substrate after 1 min by microplate scintillation counting analysis	B	8.7	pIC50	1.98	nM	IC50	J. Med. Chem. (2016) 59: 335-357 [PMID:26652717]
ChEMBL	Inhibition of PARP1 (unknown origin)	B	9.09	pIC50	0.8	nM	IC50	Bioorg. Med. Chem. Lett. (2015) 25: 4557-4561 [PMID:26342868]
ChEMBL	Inhibition of PARP1 (unknown origin)	B	9.1	pIC50	0.8	nM	IC50	J Med Chem (2019) 62: 5330-5357 [PMID:31042381]
Poly [ADP-ribose] polymerase 10 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2429708] [UniProtKB: Q53GL7]
ChEMBL	Inhibition of recombinant human His6-tagged PARP10 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	5.64	pIC50	2310	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human His6-tagged PARP10 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	5.64	pIC50	2290.87	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.24	pIC50	570	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of full length recombinant human His6-tagged PARP10 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.25	pIC50	562.34	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
Poly [ADP-ribose] polymerase 12 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2429709] [UniProtKB: Q9H0J9]
ChEMBL	Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	5.18	pIC50	6650	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human His6-tagged PARP12 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	5.18	pIC50	6606.93	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
Poly [ADP-ribose] polymerase 14 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176777] [UniProtKB: Q460N5]
ChEMBL	Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	5.05	pIC50	8912.51	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human His6-tagged PARP14 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	5.05	pIC50	8830	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
Poly [ADP-ribose] polymerase 15 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2176778] [UniProtKB: Q460N3]
ChEMBL	Inhibition of recombinant human His6-tagged PARP15 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	4.49	pIC50	32600	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human His6-tagged PARP15 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	4.49	pIC50	32359.37	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
poly(ADP-ribose) polymerase 2/Poly [ADP-ribose] polymerase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5366] [GtoPdb: 2772] [UniProtKB: Q9UGN5]
ChEMBL	Inhibition of recombinant human His6-tagged PARP2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.86	pIC50	138.04	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human His6-tagged PARP2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.86	pIC50	138	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	7.55	pIC50	28.2	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of full length recombinant human His6-tagged PARP2 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	7.55	pIC50	28.18	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of PARP2 (unknown origin)	B	9.3	pIC50	0.5	nM	IC50	J Med Chem (2019) 62: 5330-5357 [PMID:31042381]
poly (ADP-ribose) polymerase 3/Poly [ADP-ribose] polymerase 3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL5083] [GtoPdb: 2864] [UniProtKB: Q9Y6F1]
ChEMBL	Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.29	pIC50	512	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of full length recombinant human His6-tagged PARP3 expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.39	pIC50	407.38	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
Poly [ADP-ribose] polymerase 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6142] [UniProtKB: Q9UKK3]
ChEMBL	Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.08	pIC50	839	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human His6-tagged PARP4 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.08	pIC50	831.76	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
tankyrase/Tankyrase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6164] [GtoPdb: 3108] [UniProtKB: O95271]
ChEMBL	Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.84	pIC50	144.54	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human TNKS1 ADP-ribosyltransferase/sterile alpha motif domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.84	pIC50	144	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of human 6xhis-tagged ARTD5 (1030 to 1317) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ as substrate by fluorescence assay	B	7.6	pIC50	25.12	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 18-22 [PMID:24900770]
ChEMBL	Inhibition of human 6xhis-tagged ARTD5 (1030 to 1317) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ as substrate by fluorescence assay	B	7.6	pIC50	25	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 18-22 [PMID:24900770]
tankyrase 2/Tankyrase-2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6154] [GtoPdb: 3109] [UniProtKB: Q9H2K2]
ChEMBL	Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.05	pIC50	891.25	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of recombinant human TNKS2 ADP-ribosyltransferase domain expressed in Escherichia coli BL21(DE3) preincubated for 15 mins followed by biotinylated NAD+ addition by chemiluminescence assay	B	6.05	pIC50	890	nM	IC50	J Med Chem (2017) 60: 1262-1271 [PMID:28001384]
ChEMBL	Inhibition of human N-terminal 6xhis-tagged ARTD6 (873 to 1161) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ as substrate by fluorescence assay	B	7.85	pIC50	14.13	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 18-22 [PMID:24900770]
ChEMBL	Inhibition of human N-terminal 6xhis-tagged ARTD6 (873 to 1161) expressed in Escherichia coli Rosetta2 (DE3) cells using NAD+ as substrate by fluorescence assay	B	7.85	pIC50	14	nM	IC50	ACS Med. Chem. Lett. (2014) 5: 18-22 [PMID:24900770]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]