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poly (ADP-ribose) polymerase 3

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Target not currently curated in GtoImmuPdb

Target id: 2864

Nomenclature: poly (ADP-ribose) polymerase 3

Abbreviated Name: PARP3

Family: Poly ADP-ribose polymerases

Contents:

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 533 3p21.2 PARP3 poly(ADP-ribose) polymerase family member 3
Mouse - 528 9 F1 Parp3 poly (ADP-ribose) polymerase family, member 3
Rat - 526 8q32 Parp3 poly (ADP-ribose) polymerase family
Previous and Unofficial Names Click here for help
poly (ADP-ribose) polymerase family, member 3 | poly (ADP-ribose) polymerase family | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3 | ADPRTL3 | IRT1 | pADPRT-3 | poly(ADP-ribose) synthetase-3
Database Links Click here for help
Alphafold Q9Y6F1 (Hs)
CATH/Gene3D 1.20.142.10, 2.20.140.10
ChEMBL Target CHEMBL5083 (Hs)
Ensembl Gene ENSG00000041880 (Hs), ENSMUSG00000023249 (Mm), ENSRNOG00000012865 (Rn)
Entrez Gene 10039 (Hs), 235587 (Mm), 300985 (Rn)
Human Protein Atlas ENSG00000041880 (Hs)
KEGG Gene hsa:10039 (Hs), mmu:235587 (Mm), rno:300985 (Rn)
OMIM 607726 (Hs)
Pharos Q9Y6F1 (Hs)
RefSeq Nucleotide NM_005485 (Hs), NM_145619 (Mm), NM_001008328 (Rn)
RefSeq Protein NP_005476 (Hs), NP_663594 (Mm), NP_001008329 (Rn)
SynPHARM 82200 (in complex with ME0328)
UniProtKB Q9Y6F1 (Hs)
Wikipedia PARP3 (Hs)

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ME0328 Small molecule or natural product Primary target of this compound Click here for species-specific activity table Ligand has a PDB structure Hs Inhibition 6.1 pIC50 1
⤷ pIC50 6.1 (IC50 9x10-7 M) [1]
Immuno Process Associations
Immuno Process:  B cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  Cellular signalling
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  Immune regulation
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  Immune system development
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  Inflammation
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS
Immuno Process:  T cell (activation)
GO Annotations:  Associated to 1 GO processes
GO:0045829 negative regulation of isotype switching ISS

References

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1. Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan TT, Hellsten V, Weigelt J, Linusson A et al.. (2013) Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J Med Chem, 56 (23): 9556-68. [PMID:24188023]

How to cite this page

Poly ADP-ribose polymerases: poly (ADP-ribose) polymerase 3. Last modified on 28/11/2018. Accessed on 28/11/2023. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2864.