poly (ADP-ribose) polymerase 3 | Poly ADP-ribose polymerases | IUPHAR/BPS Guide to PHARMACOLOGY

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poly (ADP-ribose) polymerase 3

Target not currently curated in GtoImmuPdb

Target id: 2864

Nomenclature: poly (ADP-ribose) polymerase 3

Abbreviated Name: PARP3

Family: Poly ADP-ribose polymerases

Annotation status:  image of a grey circle Awaiting annotation/under development. Please contact us if you can help with annotation.  » Email us

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 533 3p21.2 PARP3 poly(ADP-ribose) polymerase family member 3
Mouse - 528 9 F1 Parp3 poly (ADP-ribose) polymerase family, member 3
Rat - 526 8q32 Parp3 poly (ADP-ribose) polymerase family, member 3
Previous and Unofficial Names
poly (ADP-ribose) polymerase family, member 3 | poly (ADP-ribose) polymerase family | ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase)-like 3 | ADPRTL3 | IRT1 | pADPRT-3 | poly(ADP-ribose) synthetase-3
Database Links
CATH/Gene3D
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Gene
OMIM
RefSeq Nucleotide
RefSeq Protein
SynPHARM
UniProtKB
Wikipedia

Download all structure-activity data for this target as a CSV file

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
ME0328 Hs Inhibition 6.1 pIC50 1
pIC50 6.1 (IC50 9x10-7 M) [1]

References

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1. Lindgren AE, Karlberg T, Ekblad T, Spjut S, Thorsell AG, Andersson CD, Nhan TT, Hellsten V, Weigelt J, Linusson A et al.. (2013) Chemical probes to study ADP-ribosylation: synthesis and biochemical evaluation of inhibitors of the human ADP-ribosyltransferase ARTD3/PARP3. J. Med. Chem., 56 (23): 9556-68. [PMID:24188023]

How to cite this page

Poly ADP-ribose polymerases: poly (ADP-ribose) polymerase 3. Last modified on 28/11/2018. Accessed on 19/11/2019. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=2864.