AZD0328 [Ligand Id: 7697] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2151437 (Azd 0328, Azd-0328, Azd0328, AZD-0328, AZD0328) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| nicotinic acetylcholine receptor β2 subunit/nicotinic acetylcholine receptor α4 subunit/Neuronal acetylcholine receptor; alpha4/beta2 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907589] [GtoPdb: 472, 465] [UniProtKB: P17787, P43681] | ||||||||
| ChEMBL | Binding affinity to human alpha4beta2 nAChR | B | 6.85 | pKi | 140 | nM | Ki | J Med Chem (2011) 54: 7943-7961 [PMID:21919481] |
| nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2492] [GtoPdb: 468] [UniProtKB: P36544] | ||||||||
| GtoPdb | - | - | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2011) 54: 7943-61 [PMID:21919481] |
| ChEMBL | Binding affinity to human alpha7 nAchR | B | 8.52 | pKi | 3 | nM | Ki | J Med Chem (2011) 54: 7943-7961 [PMID:21919481] |
| ChEMBL | Displacement of [125I]alpha-bungarotoxin from human alpha7 nAChR expressed in HEK293 cell membranes after 2 hrs by topcount scintillation counting analysis | B | 8.52 | pKi | 3 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 5002-5005 [PMID:29050783] |
| ChEMBL | Agonist activity at human alpha7 nAChR | F | 6.47 | pEC50 | 340 | nM | EC50 | J Med Chem (2011) 54: 7943-7961 [PMID:21919481] |
| nicotinic acetylcholine receptor α7 subunit/Neuronal acetylcholine receptor protein alpha-7 subunit in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4980] [GtoPdb: 468] [UniProtKB: Q05941] | ||||||||
| ChEMBL | Displacement of [125I]alpha-bungarotoxin from rat alpha7 nAChR expressed in HEK293 cell membranes after 2 hrs by topcount scintillation counting analysis | B | 8.3 | pKi | 5 | nM | Ki | Bioorg Med Chem Lett (2017) 27: 5002-5005 [PMID:29050783] |
| 5-HT3A/Serotonin 3a (5-HT3a) receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1899] [GtoPdb: 373] [UniProtKB: P46098] | ||||||||
| ChEMBL | Binding affinity to human 5HT3A receptor | B | 7.92 | pKi | 12 | nM | Ki | J Med Chem (2011) 54: 7943-7961 [PMID:21919481] |
| 5-HT3A in Human [GtoPdb: 379] | ||||||||
| GtoPdb | - | - | 7.92 | pKi | 12 | nM | Ki | J Med Chem (2011) 54: 7943-61 [PMID:21919481] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
