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ChEMBL ligand: CHEMBL481512 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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δ receptor/Delta opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL236] [GtoPdb: 317] [UniProtKB: P41143] | ||||||||
ChEMBL | Displacement of [3H]DPDPE from human delta opioid receptor expressed in CHOK1 cells | B | 6.18 | pKi | >667 | nM | Ki | J Med Chem (2009) 52: 610-625 [PMID:19125610] |
ChEMBL | Agonist activity at human delta opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding | F | 5.33 | pEC50 | 4696 | nM | EC50 | J Med Chem (2009) 52: 610-625 [PMID:19125610] |
κ receptor/Kappa opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL237] [GtoPdb: 318] [UniProtKB: P41145] | ||||||||
ChEMBL | Displacement of [3H]enadoline from human kappa opioid receptor expressed in HEK293 cells | B | 7.64 | pKi | 23.1 | nM | Ki | J Med Chem (2009) 52: 610-625 [PMID:19125610] |
ChEMBL | Agonist activity at human kappa opioid receptor expressed in HEK293 cells by [35S]GTPgammaS binding | F | 7.1 | pEC50 | 80 | nM | EC50 | J Med Chem (2009) 52: 610-625 [PMID:19125610] |
μ receptor/Mu opioid receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL233] [GtoPdb: 319] [UniProtKB: P35372] | ||||||||
ChEMBL | Displacement of [3H]DAMGO from human mu opioid receptor expressed in CHOK1 cells | B | 8.98 | pKi | 1.05 | nM | Ki | J Med Chem (2009) 52: 610-625 [PMID:19125610] |
ChEMBL | Agonist activity at human mu opioid receptor expressed in CHOK1 cells by [35S]GTPgammaS binding | F | 7.47 | pEC50 | 34 | nM | EC50 | J Med Chem (2009) 52: 610-625 [PMID:19125610] |
NOP receptor/Nociceptin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2014] [GtoPdb: 320] [UniProtKB: P41146] | ||||||||
ChEMBL | Displacement of [3H]N/OFQ from human NOP receptor expressed in HEK293 cells | B | 10.07 | pKi | 0.09 | nM | Ki | J Med Chem (2009) 52: 610-625 [PMID:19125610] |
GtoPdb | Binding affinity for hNOP | - | 10.07 | pKi | 0.09 | nM | Ki | J Med Chem (2009) 52: 610-25 [PMID:19125610] |
ChEMBL | Agonist activity at human NOP receptor expressed in HEK293 cells by [35S]GTPgammaS binding | F | 9.41 | pEC50 | 0.39 | nM | EC50 | J Med Chem (2009) 52: 610-625 [PMID:19125610] |
GtoPdb | Potency determined in a functional assay; [35S]GTPγS recruitment | - | 9.41 | pEC50 | 0.39 | nM | EC50 | J Med Chem (2009) 52: 610-25 [PMID:19125610] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]