BRL-15572 [Ligand Id: 10] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL534232 (BRL-15572)
  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
1 CHEMBL534232_lig_chart_1 Plasmodium falciparum Plasmodium falciparum
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  • 5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
  • This target only has 1 pki data point
2 CHEMBL534232_lig_chart_2 5-HT1A receptor Human
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  • 5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
  • This target only has 1 pki data point
3 CHEMBL534232_lig_chart_3 5-HT1B receptor Human
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  • 5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
  • This target only has 1 pki data point
4 CHEMBL534232_lig_chart_4 5-HT1D receptor Human
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  • 5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
  • This target only has 1 pki data point
5 CHEMBL534232_lig_chart_5 5-ht1e receptor Human
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  • 5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
  • This target only has 1 pki data point
6 CHEMBL534232_lig_chart_6 5-HT1F receptor Human
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  • 5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
  • This target only has 1 pki data point
7 CHEMBL534232_lig_chart_7 5-HT2A receptor Human
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  • 5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
  • This target only has 1 pki data point
8 CHEMBL534232_lig_chart_8 5-HT2B receptor Human
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  • 5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
  • This target only has 1 pki data point
9 CHEMBL534232_lig_chart_9 5-HT2C receptor Human
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  • 5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406]
  • This target only has 1 pki data point
10 CHEMBL534232_lig_chart_10 5-HT6 receptor Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against Plasmodium falciparum W2 after 72 hrs by SYBR green assay F 5 pIC50 10000 nM IC50 Nat. Chem. Biol. (2009) 5: 765-771 [PMID:19734910]
5-HT1A receptor in Human [GtoPdb: 1] [UniProtKB: P08908]
GtoPdb - - 7.7 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (1997) 356: 312-20 [PMID:9303567]
5-HT1B receptor in Human [GtoPdb: 2] [UniProtKB: P28222]
GtoPdb - - 6.1 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (1997) 356: 312-20 [PMID:9303567]
5-HT1D receptor in Human [GtoPdb: 3] [UniProtKB: P28221]
GtoPdb - - 7.9 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (1997) 356: 312-20 [PMID:9303567]
5-ht1e receptor in Human [GtoPdb: 4] [UniProtKB: P28566]
GtoPdb - - 5.2 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (1997) 356: 312-20 [PMID:9303567]
5-HT1F receptor in Human [GtoPdb: 5] [UniProtKB: P30939]
GtoPdb - - 6 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (1997) 356: 312-20 [PMID:9303567]
5-HT2A receptor in Human [GtoPdb: 6] [UniProtKB: P28223]
GtoPdb - - 6.6 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (1997) 356: 312-20 [PMID:9303567]
5-HT2B receptor in Human [GtoPdb: 7] [UniProtKB: P41595]
GtoPdb - - 7.4 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (1997) 356: 312-20 [PMID:9303567]
5-HT2C receptor in Human [GtoPdb: 8] [UniProtKB: P28335]
GtoPdb - - 6.2 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (1997) 356: 312-20 [PMID:9303567]
5-HT6 receptor in Human [GtoPdb: 11] [UniProtKB: P50406]
GtoPdb - - 5.9 pKi - - - Naunyn Schmiedebergs Arch. Pharmacol. (1997) 356: 312-20 [PMID:9303567]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]