compound 15 [PMID: 24900237] [Ligand Id: 8220] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2042829
  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells in presence of mouse plasma B 6.65 pIC50 225 nM IC50 ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237]
ChEMBL Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells B 7.35 pIC50 45 nM IC50 ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237]
ChEMBL Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasma B 7.35 pIC50 45 nM IC50 J Med Chem (2012) 55: 4580-4593 [PMID:22564207]
GtoPdb - - 7.85 pIC50 14 nM IC50 ACS Med Chem Lett (2010) 1: 493-8 [PMID:24900237]
ChEMBL Inhibition of ALK B 7.85 pIC50 14 nM IC50 ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237]
ChEMBL Inhibition of human ALK cytoplasmic domain expressed in baculovirus using GST-PLCgamma as substrate preincubated for 15 mins before substrate addition measured after 1 hr by time resolved fluorescence assay B 7.85 pIC50 14 nM IC50 J Med Chem (2012) 55: 4580-4593 [PMID:22564207]
ChEMBL Inhibition of ALK (unknown origin) B 7.85 pIC50 14 nM IC50 J Med Chem (2019) 62: 10927-10954 [PMID:31419130]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
GtoPdb - - 6.22 pIC50 597 nM IC50 ACS Med Chem Lett (2010) 1: 493-8 [PMID:24900237]
ChEMBL Inhibition of insulin receptor B 6.22 pIC50 597 nM IC50 ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237]
ChEMBL Inhibition of INSR (unknown origin) B 6.22 pIC50 597 nM IC50 J Med Chem (2019) 62: 10927-10954 [PMID:31419130]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]