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ChEMBL ligand: CHEMBL2042829 |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73] | ||||||||
ChEMBL | Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells in presence of mouse plasma | B | 6.65 | pIC50 | 225 | nM | IC50 | ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237] |
ChEMBL | Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells | B | 7.35 | pIC50 | 45 | nM | IC50 | ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237] |
ChEMBL | Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasma | B | 7.35 | pIC50 | 45 | nM | IC50 | J Med Chem (2012) 55: 4580-4593 [PMID:22564207] |
GtoPdb | - | - | 7.85 | pIC50 | 14 | nM | IC50 | ACS Med Chem Lett (2010) 1: 493-8 [PMID:24900237] |
ChEMBL | Inhibition of ALK | B | 7.85 | pIC50 | 14 | nM | IC50 | ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237] |
ChEMBL | Inhibition of human ALK cytoplasmic domain expressed in baculovirus using GST-PLCgamma as substrate preincubated for 15 mins before substrate addition measured after 1 hr by time resolved fluorescence assay | B | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2012) 55: 4580-4593 [PMID:22564207] |
ChEMBL | Inhibition of ALK (unknown origin) | B | 7.85 | pIC50 | 14 | nM | IC50 | J Med Chem (2019) 62: 10927-10954 [PMID:31419130] |
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213] | ||||||||
GtoPdb | - | - | 6.22 | pIC50 | 597 | nM | IC50 | ACS Med Chem Lett (2010) 1: 493-8 [PMID:24900237] |
ChEMBL | Inhibition of insulin receptor | B | 6.22 | pIC50 | 597 | nM | IC50 | ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237] |
ChEMBL | Inhibition of INSR (unknown origin) | B | 6.22 | pIC50 | 597 | nM | IC50 | J Med Chem (2019) 62: 10927-10954 [PMID:31419130] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]