compound 15 [PMID: 24900237] [Ligand Id: 8220] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2042829
  • ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
ALK receptor tyrosine kinase/ALK tyrosine kinase receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4247] [GtoPdb: 1839] [UniProtKB: Q9UM73]
ChEMBL Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells in presence of mouse plasma B 6.65 pIC50 225 nM IC50 ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237]
ChEMBL Inhibition of NPM-ALK autophosphorylation in human KARPAS299 cells B 7.35 pIC50 45 nM IC50 ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237]
ChEMBL Inhibition of ALK tyrosine phosphorylation in human Karpas-299 cells after 2 hrs in presence of mouse plasma B 7.35 pIC50 45 nM IC50 J Med Chem (2012) 55: 4580-4593 [PMID:22564207]
GtoPdb - - 7.85 pIC50 14 nM IC50 ACS Med Chem Lett (2010) 1: 493-8 [PMID:24900237]
ChEMBL Inhibition of ALK B 7.85 pIC50 14 nM IC50 ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237]
ChEMBL Inhibition of human ALK cytoplasmic domain expressed in baculovirus using GST-PLCgamma as substrate preincubated for 15 mins before substrate addition measured after 1 hr by time resolved fluorescence assay B 7.85 pIC50 14 nM IC50 J Med Chem (2012) 55: 4580-4593 [PMID:22564207]
ChEMBL Inhibition of ALK (unknown origin) B 7.85 pIC50 14 nM IC50 J Med Chem (2019) 62: 10927-10954 [PMID:31419130]
Insulin receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1981] [GtoPdb: 1800] [UniProtKB: P06213]
GtoPdb - - 6.22 pIC50 597 nM IC50 ACS Med Chem Lett (2010) 1: 493-8 [PMID:24900237]
ChEMBL Inhibition of insulin receptor B 6.22 pIC50 597 nM IC50 ACS Med Chem Lett (2010) 1: 493-498 [PMID:24900237]
ChEMBL Inhibition of INSR (unknown origin) B 6.22 pIC50 597 nM IC50 J Med Chem (2019) 62: 10927-10954 [PMID:31419130]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]