aciclovir [Ligand Id: 4829] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL184 (Soraway, Soothelip, Viralief, Virovir 400, Acyclovir, Herpetad, Lipsore, Virasorb, Avert, Clearsore, Aviral, Virovir 200, NSC-645011, Lypsyl, Avaclyr, Acycloguanosine, Virovir 800, Sitavig, Zovirax, Aciclovir, Cyclovir, Duvimex, Ranovir, Cymex ultra)
  • Purine nucleoside phosphorylase in Mycobacterium tuberculosis [ChEMBL: CHEMBL1169594] [UniProtKB: P9WP01]
  • purine nucleoside phosphorylase/Purine nucleoside phosphorylase in Human [ChEMBL: CHEMBL4338] [GtoPdb: 2841] [UniProtKB: P00491]
  • This target only has 1 pki data point
  • 4.04
1 CHEMBL184_lig_chart_1 Purine nucleoside phosphorylase Mycobacterium tuberculosisHuman
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Purine nucleoside phosphorylase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169594] [UniProtKB: P9WP01]
ChEMBL Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysis B 4.9 pKd 12589.25 nM Kd Bioorg. Med. Chem. (2010) 18: 4769-4774 [PMID:20570524]
purine nucleoside phosphorylase/Purine nucleoside phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4338] [GtoPdb: 2841] [UniProtKB: P00491]
ChEMBL Inhibition of human PNP B 4.04 pKi 91000 nM Ki MedChemComm (2018) 9: 1983-1993

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]