aciclovir [Ligand Id: 4829] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL184 (Aciclovir, Aciclovirum, Acycloguanosine, Acyclovir, Avaclyr, Avert, Aviral, Clearsore, Cyclovir, Cymex ultra, Duvimex, Gerpevir, Herpetad, Lipsore, Lypsyl, Novirus, NSC-645011, NSC-758477, Ranovir, Sitavig, Soothelip, Soraway, Viralief, Virasorb, Virovir 200, Virovir 400, Virovir 800, Zovirax) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Purine nucleoside phosphorylase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1169594] [UniProtKB: P9WP01] | ||||||||
| ChEMBL | Binding affinity to Mycobacterium tuberculosis purine nucleoside phosphorylase by spectrophotometric analysis | B | 4.9 | pKd | 12589.25 | nM | Kd | Bioorg Med Chem (2010) 18: 4769-4774 [PMID:20570524] |
| purine nucleoside phosphorylase/Purine nucleoside phosphorylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4338] [GtoPdb: 2841] [UniProtKB: P00491] | ||||||||
| ChEMBL | Inhibition of human PNP | B | 4.04 | pKi | 91000 | nM | Ki | Medchemcomm (2018) 9: 1983-1993 [PMID:30627387] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
