ChEMBL ligand: CHEMBL1360 (Atracurium, Tracrium)
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α3 subunit in Human [GtoPdb: 464] [UniProtKB: P32297] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α4 subunit in Human [GtoPdb: 465] [UniProtKB: P43681] There should be some charts here, you may need to enable JavaScript!
nicotinic acetylcholine receptor α7 subunit in Human [GtoPdb: 468] [UniProtKB: P36544] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
KCa2.3/Small conductance calcium-activated potassium channel protein 3 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3780] [GtoPdb: 383] [UniProtKB: P70605]
ChEMBL	Inhibition of Wistar rat recombinant SK3 channel expressed in HEK293 cells by whole cell patch clamp technique	B	5.19	pKd	6400	nM	Kd	J. Med. Chem. (2008) 51: 7625-7634 [PMID:18998663]
ChEMBL	Displacement of [I125]apamine from Wistar rat recombinant SK3 channel expressed in HEK293 cells	B	5.23	pKi	5900	nM	Ki	J. Med. Chem. (2008) 51: 7625-7634 [PMID:18998663]
nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708]
GtoPdb	Antagonism of ACh activation of α1β1εδ nACh receptors expressed in Xenopus oocytes.	-	7.01	pIC50	97	nM	IC50	Anesthesiology (2006) 105: 521-33 [PMID:16931985]
nicotinic acetylcholine receptor α3 subunit in Human [GtoPdb: 464] [UniProtKB: P32297]
GtoPdb	Antagonism of ACh activation of human α3β2 or α3β4 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations.	-	9.05	pIC50	0.9	nM	IC50	Anesthesiology (2006) 105: 521-33 [PMID:16931985]
nicotinic acetylcholine receptor α4 subunit in Human [GtoPdb: 465] [UniProtKB: P43681]
GtoPdb	Antagonism of ACh activation of human α4β2 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations.	-	8.1	pIC50	7.9	nM	IC50	Anesthesiology (2006) 105: 521-33 [PMID:16931985]
nicotinic acetylcholine receptor α7 subunit in Human [GtoPdb: 468] [UniProtKB: P36544]
GtoPdb	Antagonism of ACh activation of human α7 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations.	-	8.25	pIC50	5.6	nM	IC50	Anesthesiology (2006) 105: 521-33 [PMID:16931985]

ChEMBL data shown on this page come from version 26:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]