atracurium [Ligand Id: 9537] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL1360
  • nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708]
There should be some charts here, you may need to enable JavaScript!
  • nicotinic acetylcholine receptor α3 subunit in Human [GtoPdb: 464] [UniProtKB: P32297]
There should be some charts here, you may need to enable JavaScript!
  • nicotinic acetylcholine receptor α4 subunit in Human [GtoPdb: 465] [UniProtKB: P43681]
There should be some charts here, you may need to enable JavaScript!
  • nicotinic acetylcholine receptor α7 subunit in Human [GtoPdb: 468] [UniProtKB: P36544]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
nicotinic acetylcholine receptor α1 subunit in Human [GtoPdb: 462] [UniProtKB: P02708]
GtoPdb Antagonism of ACh activation of α1β1εδ nACh receptors expressed in Xenopus oocytes. - 7.01 pIC50 97 nM IC50 Anesthesiology (2006) 105: 521-33 [PMID:16931985]
nicotinic acetylcholine receptor α3 subunit in Human [GtoPdb: 464] [UniProtKB: P32297]
GtoPdb Antagonism of ACh activation of human α3β2 or α3β4 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. - 9.05 pIC50 0.9 nM IC50 Anesthesiology (2006) 105: 521-33 [PMID:16931985]
nicotinic acetylcholine receptor α4 subunit in Human [GtoPdb: 465] [UniProtKB: P43681]
GtoPdb Antagonism of ACh activation of human α4β2 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. - 8.1 pIC50 7.9 nM IC50 Anesthesiology (2006) 105: 521-33 [PMID:16931985]
nicotinic acetylcholine receptor α7 subunit in Human [GtoPdb: 468] [UniProtKB: P36544]
GtoPdb Antagonism of ACh activation of human α7 nACh receptors expressed in Xenopus oocytes, at different ACh concentrations. - 8.25 pIC50 5.6 nM IC50 Anesthesiology (2006) 105: 521-33 [PMID:16931985]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]