trifluridine [Ligand Id: 8697] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL1129 (F3dthd, NSC-529182, NSC-75520, T.f.t., Trifluridine, Trifluridine, Triherpine, Viroptic)
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  • Thymidylate kinase in Mycobacterium tuberculosis [ChEMBL: CHEMBL2361] [UniProtKB: P9WKE1]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Thymidine kinase in Macacine herpesvirus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075062] [UniProtKB: A3RLP8]
ChEMBL Inhibition of Herpes B virus recombinant thymidine kinase-mediated [3H]TdR phosphorylation B 5.7 pIC50 2000 nM IC50 Antimicrob Agents Chemother (2007) 51: 2028-2034 [PMID:17438061]
Thymidylate kinase in Mycobacterium tuberculosis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2361] [UniProtKB: P9WKE1]
ChEMBL Inhibitory activity against thymidine monophosphate kinase (TMPK) in Mycobacterium tuberculosis B 4.01 pKi 97000 nM Ki Bioorg Med Chem Lett (2003) 13: 3045-3048 [PMID:12941330]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]