zaragozic acid C [Ligand Id: 3073] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL505374 (Zaragozic Acid C)
  • squalene synthase /Squalene synthetase in Human [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268]
  • squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268]
ChEMBL Inhibition of squalene synthase B 9.52 pIC50 0.3 nM IC50 J Nat Prod (1996) 59: 52-54
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
ChEMBL Inhibition of rat squalene synthase B 10.35 pKi 0.04 nM Ki J Nat Prod (1996) 59: 52-54
GtoPdb Inhibition of rat squalene synthase - 10.4 pKi 0.05 nM Ki Proc Natl Acad Sci USA (1993) 90: 80-4 [PMID:8419946];
Tetrahedron (1992) 48: 10221-10226
ChEMBL Inhibition of rat liver squalene synthase by liqiud scintillation counting B 9.4 pIC50 0.4 nM IC50 J Nat Prod (1993) 56: 1923-1929 [PMID:8289063]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]