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ChEMBL ligand: CHEMBL505374 (Zaragozic Acid C) |
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DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
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squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268] | ||||||||
ChEMBL | Inhibition of squalene synthase | B | 9.52 | pIC50 | 0.3 | nM | IC50 | J Nat Prod (1996) 59: 52-54 |
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] | ||||||||
ChEMBL | Inhibition of rat squalene synthase | B | 10.35 | pKi | 0.04 | nM | Ki | J Nat Prod (1996) 59: 52-54 |
GtoPdb | Inhibition of rat squalene synthase | - | 10.4 | pKi | 0.05 | nM | Ki |
Proc Natl Acad Sci USA (1993) 90: 80-4 [PMID:8419946]; Tetrahedron (1992) 48: 10221-10226 |
ChEMBL | Inhibition of rat liver squalene synthase by liqiud scintillation counting | B | 9.4 | pIC50 | 0.4 | nM | IC50 | J Nat Prod (1993) 56: 1923-1929 [PMID:8289063] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]