ChEMBL ligand: CHEMBL505374 (Zaragozic Acid C)
squalene synthase /Squalene synthetase in Human [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268] squalene synthase /Squalene synthetase in Rat [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
squalene synthase /Squalene synthetase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3338] [GtoPdb: 645] [UniProtKB: P37268]
ChEMBL	Inhibition of squalene synthase	B	9.52	pIC50	0.3	nM	IC50	J Nat Prod (1996) 59: 52-54
squalene synthase /Squalene synthetase in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3815] [GtoPdb: 645] [UniProtKB: Q02769]
ChEMBL	Inhibition of rat squalene synthase	B	10.35	pKi	0.04	nM	Ki	J Nat Prod (1996) 59: 52-54
GtoPdb	Inhibition of rat squalene synthase	-	10.4	pKi	0.05	nM	Ki	Proc Natl Acad Sci USA (1993) 90: 80-4 [PMID:8419946]; Tetrahedron (1992) 48: 10221-10226
ChEMBL	Inhibition of rat liver squalene synthase by liqiud scintillation counting	B	9.4	pIC50	0.4	nM	IC50	J Nat Prod (1993) 56: 1923-1929 [PMID:8289063]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]