ChEMBL ligand: CHEMBL1213082
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/phosphoinositide-3-kinase regulatory subunit 1/PI3-kinase p110-delta/p85-alpha in Human [ChEMBL: CHEMBL2111432] [GtoPdb: 2155, 2503] [UniProtKB: O00329, P27986] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329] There should be some charts here, you may need to enable JavaScript!
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/PI3-kinase p110-alpha subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4005] [GtoPdb: 2153] [UniProtKB: P42336]
ChEMBL	Inhibition of PI3Kalpha (unknown origin)	B	4	pIC50	>100000	nM	IC50	Medchemcomm (2012) 3: 1337-1355
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta/PI3-kinase p110-beta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3145] [GtoPdb: 2154] [UniProtKB: P42338]
ChEMBL	Inhibition of PI3Kbeta (unknown origin)	B	4.12	pIC50	75000	nM	IC50	Medchemcomm (2012) 3: 1337-1355
ChEMBL	Inhibition of p110beta	B	4.8	pIC50	16000	nM	IC50	Nat Chem Biol (2010) 6: 117-124 [PMID:20081827]
ChEMBL	Inhibition of PI3Kbeta in presence of 10 uM ATP	B	4.8	pIC50	16000	nM	IC50	J Med Chem (2012) 55: 8559-8581 [PMID:22924688]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/phosphoinositide-3-kinase regulatory subunit 1/PI3-kinase p110-delta/p85-alpha in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2111432] [GtoPdb: 2155, 2503] [UniProtKB: O00329, P27986]
GtoPdb	-	-	7.7	pKi	~20	nM	Ki	Chem Biol (2005) 12: 621-37 [PMID:15975507]
ChEMBL	Inhibition of human recombinant full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 insect cells using PI:PS as substrate after 60 mins by ADP-Glo assay	B	7.7	pKi	19.95	nM	Ki	J Med Chem (2017) 60: 4304-4315 [PMID:28489362]
ChEMBL	Inhibition of human recombinant full length N-terminal His6-tagged PI3K p110delta/p85alpha expressed in baculovirus infected Sf9 insect cells using PI:PS as substrate after 60 mins by ADP-Glo assay	B	7.9	pKi	12.59	nM	Ki	J Med Chem (2017) 60: 4304-4315 [PMID:28489362]
GtoPdb	-	-	6.3	pIC50	500	nM	IC50	J Immunol (2003) 170: 2647-54 [PMID:12594293]
ChEMBL	Inhibition of full length recombinant human N-terminal His6-tagged PI3K p110delta/human p85alpha expressed in baculovirus infected sf21 cells using PIP2 as substrate preincubated for 30 mins followed by substrate addition by HTRF assay	B	6.89	pIC50	130	nM	IC50	ACS Med Chem Lett (2017) 8: 118-123 [PMID:28105286]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta/PI3-kinase p110-delta subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3130] [GtoPdb: 2155] [UniProtKB: O00329]
ChEMBL	Inhibition of p110delta	B	7.7	pKi	20	nM	Ki	Chem Biol (2005) 12: 621-637 [PMID:15975507]
GtoPdb	-	-	7.7	pKi	~20	nM	Ki	Chem Biol (2005) 12: 621-37 [PMID:15975507]
GtoPdb	-	-	6.3	pIC50	500	nM	IC50	J Immunol (2003) 170: 2647-54 [PMID:12594293]
ChEMBL	Inhibition of PI3Kdelta (unknown origin)	B	6.3	pIC50	500	nM	IC50	Medchemcomm (2012) 3: 1337-1355
ChEMBL	Inhibition of PI3Kdelta in presence of 200 uM ATP	B	6.3	pIC50	500	nM	IC50	J Med Chem (2012) 55: 8559-8581 [PMID:22924688]
ChEMBL	Inhibition of PI3K-delta (unknown origin) by cell free biochemical assay	B	6.8	pIC50	160	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1005-1010 [PMID:29486969]
ChEMBL	Inhibition of p110delta	B	6.89	pIC50	130	nM	IC50	Nat Chem Biol (2010) 6: 117-124 [PMID:20081827]
ChEMBL	Inhibition of PI3Kdelta in presence of 10 uM ATP	B	6.89	pIC50	130	nM	IC50	J Med Chem (2012) 55: 8559-8581 [PMID:22924688]
ChEMBL	Inhibition of PI3K-delta (unknown origin) expressed in baculovirus infected Sf9 insect cells after 10 mins in presence of [gamma-32P]ATP by radioligand binding assay	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1005-1010 [PMID:29486969]
ChEMBL	Inhibition of PI3Kdelta in human PBMC assessed as reduction in anti-human CD28 antibody stimulated IL-6 secretion levels after 72 hrs by ELISA	B	7.3	pIC50	50.12	nM	IC50	J Med Chem (2017) 60: 4304-4315 [PMID:28489362]
ChEMBL	Inhibition of PI3Kdelta in human PBMC assessed as reduction in anti-human CD28 antibody stimulated IL-6 secretion levels after 72 hrs by ELISA	B	7.6	pIC50	25.12	nM	IC50	J Med Chem (2017) 60: 4304-4315 [PMID:28489362]
phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma/PI3-kinase p110-gamma subunit in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3267] [GtoPdb: 2156] [UniProtKB: P48736]
ChEMBL	Inhibition of PI3K-gamma (unknown origin) by cell free biochemical assay	B	4.15	pIC50	70000	nM	IC50	Bioorg Med Chem Lett (2018) 28: 1005-1010 [PMID:29486969]
ChEMBL	Inhibition of p110gamma	B	4.21	pIC50	61000	nM	IC50	Nat Chem Biol (2010) 6: 117-124 [PMID:20081827]
ChEMBL	Inhibition of PI3Kgamma in presence of 10 uM ATP	B	4.21	pIC50	61000	nM	IC50	J Med Chem (2012) 55: 8559-8581 [PMID:22924688]
ChEMBL	Inhibition of PI3Kgamma (unknown origin)	B	4.54	pIC50	29000	nM	IC50	Medchemcomm (2012) 3: 1337-1355

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]