[3H]ORG2058 [Ligand Id: 3454] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2311103 (ORG-2058) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] | ||||||||
| ChEMBL | Dissociation constant for [3H]-ORG2058 at human progesterone receptor at 310K | B | 8.27 | pKd | 5.42 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 308 K | B | 8.34 | pKd | 4.56 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 303 K | B | 8.38 | pKd | 4.13 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 273 K | B | 8.48 | pKd | 3.28 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 298 K | B | 8.5 | pKd | 3.16 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]-ORG2058 at human progesterone receptor at 278 K | B | 8.57 | pKd | 2.7 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 293K | B | 8.58 | pKd | 2.64 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]-ORG2058 at human progesterone receptor at 283 K | B | 8.6 | pKd | 2.49 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 288 K | B | 8.63 | pKd | 2.32 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
