[3H]ORG2058 [Ligand Id: 3454] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL2311103 (ORG-2058) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401] | ||||||||
| ChEMBL | Dissociation constant for [3H]-ORG2058 at human progesterone receptor at 310K | B | 8.27 | pKd | 5.42 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 308 K | B | 8.34 | pKd | 4.56 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 303 K | B | 8.38 | pKd | 4.13 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 273 K | B | 8.48 | pKd | 3.28 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 298 K | B | 8.5 | pKd | 3.16 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]-ORG2058 at human progesterone receptor at 278 K | B | 8.57 | pKd | 2.7 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 293K | B | 8.58 | pKd | 2.64 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]-ORG2058 at human progesterone receptor at 283 K | B | 8.6 | pKd | 2.49 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
| ChEMBL | Dissociation constant for [3H]ORG2058 at human progesterone receptor at 288 K | B | 8.63 | pKd | 2.32 | nM | Kd | J Med Chem (2005) 48: 2026-2035 [PMID:15771445] |
ChEMBL data shown on this page come from version 35:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
