[3H]ORG2058 [Ligand Id: 3454] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL2311103 (ORG-2058)
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Progesterone receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL208] [GtoPdb: 627] [UniProtKB: P06401]
ChEMBL Dissociation constant for [3H]-ORG2058 at human progesterone receptor at 310K B 8.27 pKd 5.42 nM Kd J. Med. Chem. (2005) 48: 2026-2035 [PMID:15771445]
ChEMBL Dissociation constant for [3H]ORG2058 at human progesterone receptor at 308 K B 8.34 pKd 4.56 nM Kd J. Med. Chem. (2005) 48: 2026-2035 [PMID:15771445]
ChEMBL Dissociation constant for [3H]ORG2058 at human progesterone receptor at 303 K B 8.38 pKd 4.13 nM Kd J. Med. Chem. (2005) 48: 2026-2035 [PMID:15771445]
ChEMBL Dissociation constant for [3H]ORG2058 at human progesterone receptor at 273 K B 8.48 pKd 3.28 nM Kd J. Med. Chem. (2005) 48: 2026-2035 [PMID:15771445]
ChEMBL Dissociation constant for [3H]ORG2058 at human progesterone receptor at 298 K B 8.5 pKd 3.16 nM Kd J. Med. Chem. (2005) 48: 2026-2035 [PMID:15771445]
ChEMBL Dissociation constant for [3H]-ORG2058 at human progesterone receptor at 278 K B 8.57 pKd 2.7 nM Kd J. Med. Chem. (2005) 48: 2026-2035 [PMID:15771445]
ChEMBL Dissociation constant for [3H]ORG2058 at human progesterone receptor at 293K B 8.58 pKd 2.64 nM Kd J. Med. Chem. (2005) 48: 2026-2035 [PMID:15771445]
ChEMBL Dissociation constant for [3H]-ORG2058 at human progesterone receptor at 283 K B 8.6 pKd 2.49 nM Kd J. Med. Chem. (2005) 48: 2026-2035 [PMID:15771445]
ChEMBL Dissociation constant for [3H]ORG2058 at human progesterone receptor at 288 K B 8.63 pKd 2.32 nM Kd J. Med. Chem. (2005) 48: 2026-2035 [PMID:15771445]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]