ChEMBL ligand: CHEMBL376488 (Bedaquiline, R-207910, R207910, Sirturo, TMC-207, TMC207)
ATP synthase subunit c in Bacillus sp. [ChEMBL: CHEMBL3308989] [UniProtKB: P00845] There should be some charts here, you may need to enable JavaScript!
Kv11.1/HERG in Human [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809] There should be some charts here, you may need to enable JavaScript!
Putative uncharacterized protein atpE in Mycobacterium smegmatis [ChEMBL: CHEMBL1641346] [UniProtKB: Q5TIX5] There should be some charts here, you may need to enable JavaScript!
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
ATP synthase subunit c in Bacillus sp. (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3308989] [UniProtKB: P00845]
ChEMBL	Binding affinity to Bacillus PS3 ATP synthase subunit c	B	6.3	pKd	500	nM	Kd	Nat Chem Biol (2007) 3: 323-324 [PMID:17496888]
Kv11.1/HERG in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL240] [GtoPdb: 572] [UniProtKB: Q12809]
ChEMBL	Inhibition of human ERG	B	5.8	pIC50	1600	nM	IC50	Bioorg Med Chem (2019) 27: 1292-1307 [PMID:30803745]
ChEMBL	Inhibition of human ERG	B	5.8	pIC50	1600	nM	IC50	Bioorg Med Chem (2020) 28: 115213-115213 [PMID:31810890]
ChEMBL	Inhibition of human ERG by patch clamp assay	B	5.8	pIC50	1600	nM	IC50	Bioorg Med Chem (2018) 26: 1797-1809 [PMID:29482950]
ChEMBL	Inhibition of human ERG	B	5.8	pIC50	1600	nM	IC50	ACS Med Chem Lett (2017) 8: 1019-1024 [PMID:29057044]
ChEMBL	Inhibition of human ERG by manual patch clamp electrophysiology assay	B	5.8	pIC50	1600	nM	IC50	Bioorg Med Chem (2019) 27: 1283-1291 [PMID:30792104]
ChEMBL	Inhibition of human ERG assessed as prolongation of QT interval	B	6.43	pIC50	370	nM	IC50	Bioorg Med Chem (2018) 26: 1797-1809 [PMID:29482950]
ChEMBL	Inhibition of human ERG	B	6.43	pIC50	370	nM	IC50	Bioorg Med Chem Lett (2017) 27: 5190-5196 [PMID:29107541]
ChEMBL	Inhibition of fluorescently labelled tracer binding to human ERG by competitive binding assay	B	4.82	pEC50	15000	nM	EC50	RSC Med Chem (2021) 12: 943-959 [PMID:34223160]
Putative uncharacterized protein atpE in Mycobacterium smegmatis (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1641346] [UniProtKB: Q5TIX5]
ChEMBL	Inhibition of Mycobacterium smegmatis ATCC 607 ATP synthase subunit c-mediated ATP synthesis after 60 mins by luminometry	B	7.6	pIC50	25	nM	IC50	Nat Chem Biol (2007) 3: 323-324 [PMID:17496888]
ChEMBL	Inhibition of Mycobacterium smegmatis MC2 155 ATP synthase subunit c-mediated ATP production	B	8	pIC50	10	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1290-1292 [PMID:19075053]
ChEMBL	Inhibition of Mycobacterium smegmatis MC2 155 ATP synthase subunit c-mediated ATP production at 100 nM	B	8	pIC50	10	nM	IC50	Antimicrob Agents Chemother (2009) 53: 1290-1292 [PMID:19075053]
ChEMBL	Inhibition of Mycobacterium smegmatis ATCC 607 ATP synthase subunit c-mediated ATP synthesis after 60 mins by luminometry	B	8.6	pIC50	2.5	nM	IC50	Nat Chem Biol (2007) 3: 323-324 [PMID:17496888]
CoV Replicase polyprotein 1ab/CoV RNA-dependent RNA polymerase/CoV Non-structural protein 15/CoV Non-structural protein 13/Replicase polyprotein 1ab in Severe acute respiratory syndrome coronavirus 2 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4523582] [GtoPdb: 3125, 3139, 3206, 3261] [UniProtKB: P0DTD1]
ChEMBL	SARS-CoV-2 3CL-Pro protease inhibition IC50 determined by FRET kind of response from peptide substrate	F	5.36	pIC50	4360	nM	IC50	Identification of inhibitors of SARS-Cov2 M-Pro enzymatic activity using a small molecule repurposing screen

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]