cloprostenol [Ligand Id: 1894] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL37853 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| GtoPdb | - | - | 4.8 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Affinity for human Prostaglandin D2 receptor expressed in HEK293 cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| GtoPdb | - | - | 6.1 | pKi | - | - | - |
Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]; J Pharm Pharmacol (2002) 54: 539-47 [PMID:11999132] |
| ChEMBL | Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. | B | 6.3 | pIC50 | 496 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=80%) | F | 6.12 | pEC50 | 760 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| ChEMBL | Affinity for Prostanoid EP2 receptor expressed in CHO cells | B | 5.43 | pIC50 | 3700 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| GtoPdb | - | - | 8.36 | pKi | 4.4 | nM | Ki | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Affinity for Prostanoid EP3 receptor expressed in CHO cell line | B | 6.2 | pIC50 | 635 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3(% of control ligand, sulprostone=75%) | F | 5.3 | pEC50 | 5000 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| GtoPdb | - | - | 6.66 | pEC50 | 221 | nM | EC50 | J Pharmacol Exp Ther (1998) 286: 1094-102 [PMID:9694973] |
| EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| ChEMBL | Affinity for Prostanoid EP4 receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
| ChEMBL | Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2000) 43: 3400-3407 [PMID:10978187] |
| GtoPdb | - | - | 9.3 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Affinity for human Prostanoid FP receptor expressed in COS-7 cells | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%) | F | 8 | pEC50 | 10 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
| ChEMBL | Affinity for Prostaglandin I2 receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| GtoPdb | - | - | 5.2 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Affinity for Prostanoid TP receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human TP-receptor (% of control ligand, [3H]-U-46,619=100%) | F | 5.62 | pEC50 | 2400 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
