cloprostenol [Ligand Id: 1894] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL37853 |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| DP1 receptor/Prostanoid DP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4427] [GtoPdb: 338] [UniProtKB: Q13258] | ||||||||
| GtoPdb | - | - | 4.8 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Affinity for human Prostaglandin D2 receptor expressed in HEK293 cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| EP1 receptor/Prostanoid EP1 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1811] [GtoPdb: 340] [UniProtKB: P34995] | ||||||||
| GtoPdb | - | - | 6.1 | pKi | - | - | - |
Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944]; J Pharm Pharmacol (2002) 54: 539-47 [PMID:11999132] |
| ChEMBL | Affinity for Prostanoid EP1 receptor expressed in COS-7 cells. | B | 6.3 | pIC50 | 496 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP1 (% of control ligand, 17-phi-PGE2=80%) | F | 6.12 | pEC50 | 760 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| EP2 receptor/Prostanoid EP2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1881] [GtoPdb: 341] [UniProtKB: P43116] | ||||||||
| ChEMBL | Affinity for Prostanoid EP2 receptor expressed in CHO cells | B | 5.43 | pIC50 | 3700 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| EP3 receptor/Prostanoid EP3 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3710] [GtoPdb: 342] [UniProtKB: P43115] | ||||||||
| GtoPdb | - | - | 8.36 | pKi | 4.4 | nM | Ki | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Affinity for Prostanoid EP3 receptor expressed in CHO cell line | B | 6.2 | pIC50 | 635 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human Prostaglandin E receptor EP3(% of control ligand, sulprostone=75%) | F | 5.3 | pEC50 | 5000 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| GtoPdb | - | - | 6.66 | pEC50 | 221 | nM | EC50 | J Pharmacol Exp Ther (1998) 286: 1094-102 [PMID:9694973] |
| EP4 receptor/Prostanoid EP4 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1836] [GtoPdb: 343] [UniProtKB: P35408] | ||||||||
| ChEMBL | Affinity for Prostanoid EP4 receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| FP receptor/Prostanoid FP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1987] [GtoPdb: 344] [UniProtKB: P43088] | ||||||||
| ChEMBL | Inhibitory Binding constant (n=2) to Prostanoid FP receptor expressed in bovine corpus luteum | B | 7.51 | pKi | 31 | nM | Ki | J Med Chem (2000) 43: 3400-3407 [PMID:10978187] |
| GtoPdb | - | - | 9.3 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Affinity for human Prostanoid FP receptor expressed in COS-7 cells | B | 8.7 | pIC50 | 2 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Displacement of [3H]PGF2-alpha from human FP-receptor expressed in CHO-KI cells | B | 9 | pIC50 | 1 | nM | IC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human FP-receptor (% of control ligand, fluprostenol=100%) | F | 8 | pEC50 | 10 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
| IP receptor/Prostanoid IP receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1995] [GtoPdb: 345] [UniProtKB: P43119] | ||||||||
| ChEMBL | Affinity for Prostaglandin I2 receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| TP receptor/Thromboxane A2 receptor in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2069] [GtoPdb: 346] [UniProtKB: P21731] | ||||||||
| GtoPdb | - | - | 5.2 | pKi | - | - | - | Biochim Biophys Acta (2000) 1483: 285-93 [PMID:10634944] |
| ChEMBL | Affinity for Prostanoid TP receptor expressed in CHO cells | B | 5 | pIC50 | >10000 | nM | IC50 | J Med Chem (2000) 43: 945-952 [PMID:10715159] |
| ChEMBL | Functional activity in RAT-1cells, transiently-transfected with human TP-receptor (% of control ligand, [3H]-U-46,619=100%) | F | 5.62 | pEC50 | 2400 | nM | EC50 | Bioorg Med Chem Lett (2000) 10: 1519-1522 [PMID:10915040] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
