fanapanel [Ligand Id: 7636] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL19892 (Fanapanel, Zk200775, ZK-200775, ZK200775) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7] | ||||||||
| ChEMBL | Displacement of [3H]DCKA from glycine NMDA receptor of rat cortical membranes | B | 5 | pIC50 | >10000 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1205-1210 [PMID:11354378] |
| ChEMBL | Inhibition of NMDA receptor glycine site from rat cortical membrane | B | 5.29 | pIC50 | 5150 | nM | IC50 | J Med Chem (2010) 53: 5367-5382 [PMID:20356304] |
| ChEMBL | Inhibition of NMDA receptor glutamate site from rat cortical membrane | B | 5.55 | pIC50 | 2800 | nM | IC50 | J Med Chem (2010) 53: 5367-5382 [PMID:20356304] |
| GluA1/GluA2/GluA3/GluA4/Glutamate receptor ionotropic, AMPA in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2093871] [GtoPdb: 444, 445, 446, 447] [UniProtKB: P19490, P19491, P19492, P19493] | ||||||||
| ChEMBL | Displacement of [3H]AMPA from Ionotropic glutamate receptor AMPA of rat cortical membranes | B | 6.85 | pIC50 | 140 | nM | IC50 | Bioorg Med Chem Lett (2001) 11: 1205-1210 [PMID:11354378] |
ChEMBL data shown on this page come from version 33:
Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
