GtoPdb Ligand ID: 8412

Synonyms: AB0024 | GS 6624 | GS-6624
Compound class: Antibody
Comment: Simtuzumab is an investigational monoclonal antibody targeting lysyl oxidase-like 2 (LOXL2). The antibody is reported to be an allosteric modulator of LOXL2 enzymatic activity [6-7].
Peptide sequence information for this antibody is available from its IMGT/mAb-DB record. Peptide sequence matches reveal that US8461303 is the covering patent [7]. The heavy chain variable domain sequence of simtuzumab (from IMGT) matches the sequence for the AB0023 M20 variant 3 clone in US8461303.
Compound class Antibody
International Nonproprietary Names
INN number INN
9626 simtuzumab
AB0024 | GS 6624 | GS-6624
Database Links
Specialist databases
IMGT/mAb-DB 430
Other databases
GtoPdb PubChem SID 252166622
Search PubMed clinical trials simtuzumab
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Wikipedia Simtuzumab