nacubactam [Ligand Id: 10833] activity data from GtoPdb and ChEMBL
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| ChEMBL ligand: CHEMBL3989959 (FPI-1459, Nacubactam, RG-6080, RG6080, RO-7079901, RO7079901) |
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| DB | Assay description | Assay Type | Standard value | Standard parameter | Original value | Original units | Original parameter | Reference |
|---|---|---|---|---|---|---|---|---|
| Beta-lactamase in Enterobacter cloacae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2725] [UniProtKB: P05364] | ||||||||
| ChEMBL | Inhibition of Enterobacter cloacae AmpC | B | 6.07 | pIC50 | 845 | nM | IC50 | Eur J Med Chem (2022) 242: 114677-114677 [PMID:35988449] |
| Beta-lactamase CTX-M-14 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287630] [UniProtKB: Q9L5C7] | ||||||||
| ChEMBL | Inhibition of Escherichia coli beta-lactamase CTX-M-14 | B | 8 | pIC50 | 10 | nM | IC50 | Eur J Med Chem (2022) 242: 114677-114677 [PMID:35988449] |
| Beta-lactamase OXA-1 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4951] [UniProtKB: P13661] | ||||||||
| ChEMBL | Inhibition of Escherichia coli beta-lactamase OXA-1 | B | 5.52 | pIC50 | 3050 | nM | IC50 | Eur J Med Chem (2022) 242: 114677-114677 [PMID:35988449] |
| Beta-lactamase OXA-23 in Acinetobacter baumannii (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3885669] [UniProtKB: Q9L4P2] | ||||||||
| ChEMBL | Inhibition of Acinetobacter baumannii beta-lactamase OXA-23 | B | 4.33 | pIC50 | 46400 | nM | IC50 | Eur J Med Chem (2022) 242: 114677-114677 [PMID:35988449] |
| Beta-lactamase TEM-1 in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1287599] [UniProtKB: Q4GY26] | ||||||||
| ChEMBL | Inhibition of Escherichia coli beta-lactamase TEM-1 | B | 7.59 | pIC50 | 26 | nM | IC50 | Eur J Med Chem (2022) 242: 114677-114677 [PMID:35988449] |
| Carbepenem-hydrolyzing beta-lactamase KPC in Klebsiella pneumoniae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL6132] [UniProtKB: Q9F663] | ||||||||
| ChEMBL | Inhibition of Klebsiella pneumoniae beta-lactamase KPC-2 | B | 6.06 | pIC50 | 869 | nM | IC50 | Eur J Med Chem (2022) 242: 114677-114677 [PMID:35988449] |
ChEMBL data shown on this page come from version 34:
Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]
