ChEMBL ligand: CHEMBL417149
Caspase 1/Caspase-1 in Human [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] There should be some charts here, you may need to enable JavaScript!
Caspase 3/Caspase-3 in Human [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574] There should be some charts here, you may need to enable JavaScript!
Caspase 7/Caspase-7 in Human [ChEMBL: CHEMBL3468] [GtoPdb: 1623] [UniProtKB: P55210] There should be some charts here, you may need to enable JavaScript!
Caspase 8/Caspase-8 in Human [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466]
ChEMBL	Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrate	B	4.15	pIC50	70000	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1477-1482 [PMID:9873373]
ChEMBL	Inhibitory activity against caspase-1	B	6.72	pIC50	190	nM	IC50	Bioorg Med Chem Lett (2004) 14: 805-808 [PMID:14741294]
Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574]
ChEMBL	Inhibition of recombinant human caspase-3 activity using Ac-DEVD-AMC as substrate preincubated for 10 mins by fluorescence assay	B	7.12	pIC50	75.7	nM	IC50	Bioorg Med Chem (2014) 22: 6735-6745 [PMID:25468037]
ChEMBL	Inhibitory concentration of compound against caspase-3	B	7.36	pIC50	43.9	nM	IC50	J Med Chem (2004) 47: 2466-2474 [PMID:15115390]
ChEMBL	Inhibitory concentration required against human Caspase-3	B	7.57	pIC50	27	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2137-2140 [PMID:12798321]
ChEMBL	Inhibitory activity against caspase-3	B	7.57	pIC50	27	nM	IC50	Bioorg Med Chem Lett (2004) 14: 805-808 [PMID:14741294]
ChEMBL	Inhibition of caspase3	B	7.68	pIC50	21	nM	IC50	J Med Chem (2006) 49: 1613-1623 [PMID:16509578]
ChEMBL	Inhibition of human recombinant caspase 3 assessed as accumulation of fluorogenic product by fluorometric assay	B	8.66	pIC50	2.2	nM	IC50	J Med Chem (2009) 52: 2188-2191 [PMID:19326941]
ChEMBL	Inhibition of human caspase 3 by fluorometric assay	B	8.66	pIC50	2.2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2192-2197 [PMID:21441025]
ChEMBL	Inhibition of His-tagged human recombinant caspase 3 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay	B	8.77	pIC50	1.7	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3195-3201 [PMID:27216999]
ChEMBL	Inhibition of human recombinant caspase 3 assessed as fluorescent 7-amido-4-methylcoumarin release	B	8.8	pIC50	1.6	nM	IC50	Eur J Med Chem (2010) 45: 3858-3863 [PMID:20541849]
ChEMBL	Inhibition of recombinant human caspase-3 using Ac-LDEVD-AMC as substrate assessed as accumulation of 7-AMC incubated for 10 mins followed by substrate addition measured for 10 mins by fluorimetric analysis	B	9.7	pIC50	0.2	nM	IC50	Bioorg Med Chem (2013) 21: 2960-2967 [PMID:23632366]
GtoPdb	-	-	9.8	pIC50	0.16	nM	IC50	Eur J Med Chem (2010) 45: 3858-63 [PMID:20541849]
Caspase 7/Caspase-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3468] [GtoPdb: 1623] [UniProtKB: P55210]
ChEMBL	Inhibition of recombinant human caspase-7 activity using Ac-DEVD-AMC as substrate preincubated for 10 mins by fluorescence assay	B	6.81	pIC50	155.2	nM	IC50	Bioorg Med Chem (2014) 22: 6735-6745 [PMID:25468037]
ChEMBL	Inhibitory activity against caspase-7	B	7.06	pIC50	87	nM	IC50	Bioorg Med Chem Lett (2004) 14: 805-808 [PMID:14741294]
ChEMBL	Inhibition of His-tagged human recombinant caspase 7 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay	B	7.22	pIC50	60.4	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3195-3201 [PMID:27216999]
ChEMBL	Inhibition of human recombinant caspase 7 assessed as fluorescent 7-amido-4-methylcoumarin release	B	7.23	pIC50	59.1	nM	IC50	Eur J Med Chem (2010) 45: 3858-3863 [PMID:20541849]
ChEMBL	Inhibition of human recombinant caspase 7 assessed as accumulation of fluorogenic product by fluorometric assay	B	8.53	pIC50	2.95	nM	IC50	J Med Chem (2009) 52: 2188-2191 [PMID:19326941]
ChEMBL	Inhibition of caspase 7 by fluorometric assay	B	8.54	pIC50	2.9	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2192-2197 [PMID:21441025]
Caspase 8/Caspase-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790]
ChEMBL	Inhibitory activity against caspase-8	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2004) 14: 805-808 [PMID:14741294]

ChEMBL data shown on this page come from version 33:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]