ChEMBL ligand: CHEMBL417149
Caspase 1/Caspase-1 in Human [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466] There should be some charts here, you may need to enable JavaScript!
Caspase 3/Caspase-3 in Human [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574] There should be some charts here, you may need to enable JavaScript!
Caspase 7/Caspase-7 in Human [ChEMBL: CHEMBL3468] [GtoPdb: 1623] [UniProtKB: P55210] There should be some charts here, you may need to enable JavaScript!
Caspase 8/Caspase-8 in Human [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466]
ChEMBL	Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrate	B	4.15	pIC50	70000	nM	IC50	Bioorg Med Chem Lett (1998) 8: 1477-1482 [PMID:9873373]
ChEMBL	Inhibitory activity against caspase-1	B	6.72	pIC50	190	nM	IC50	Bioorg Med Chem Lett (2004) 14: 805-808 [PMID:14741294]
ChEMBL	Inhibition of caspase-1 (unknown origin)	B	6.72	pIC50	190	nM	IC50	J Med Chem (2021) 64: 1786-1815 [PMID:33569941]
Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574]
ChEMBL	Inhibition of recombinant human caspase-3 activity using Ac-DEVD-AMC as substrate preincubated for 10 mins by fluorescence assay	B	7.12	pIC50	75.7	nM	IC50	Bioorg Med Chem (2014) 22: 6735-6745 [PMID:25468037]
ChEMBL	Inhibitory concentration of compound against caspase-3	B	7.36	pIC50	43.9	nM	IC50	J Med Chem (2004) 47: 2466-2474 [PMID:15115390]
ChEMBL	Inhibitory concentration required against human Caspase-3	B	7.57	pIC50	27	nM	IC50	Bioorg Med Chem Lett (2003) 13: 2137-2140 [PMID:12798321]
ChEMBL	Inhibitory activity against caspase-3	B	7.57	pIC50	27	nM	IC50	Bioorg Med Chem Lett (2004) 14: 805-808 [PMID:14741294]
ChEMBL	Inhibition of caspase-3 (unknown origin)	B	7.57	pIC50	27	nM	IC50	J Med Chem (2021) 64: 1786-1815 [PMID:33569941]
ChEMBL	Inhibition of caspase3	B	7.68	pIC50	21	nM	IC50	J Med Chem (2006) 49: 1613-1623 [PMID:16509578]
ChEMBL	Inhibition of human caspase 3 by fluorometric assay	B	8.66	pIC50	2.2	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2192-2197 [PMID:21441025]
ChEMBL	Inhibition of human recombinant caspase 3 assessed as accumulation of fluorogenic product by fluorometric assay	B	8.66	pIC50	2.2	nM	IC50	J Med Chem (2009) 52: 2188-2191 [PMID:19326941]
ChEMBL	Inhibition of His-tagged human recombinant caspase 3 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay	B	8.77	pIC50	1.7	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3195-3201 [PMID:27216999]
ChEMBL	Inhibition of human recombinant caspase 3 assessed as fluorescent 7-amido-4-methylcoumarin release	B	8.8	pIC50	1.6	nM	IC50	Eur J Med Chem (2010) 45: 3858-3863 [PMID:20541849]
ChEMBL	Inhibition of recombinant human caspase-3 using Ac-LDEVD-AMC as substrate assessed as accumulation of 7-AMC incubated for 10 mins followed by substrate addition measured for 10 mins by fluorimetric analysis	B	9.7	pIC50	0.2	nM	IC50	Bioorg Med Chem (2013) 21: 2960-2967 [PMID:23632366]
GtoPdb	-	-	9.8	pIC50	0.16	nM	IC50	Eur J Med Chem (2010) 45: 3858-63 [PMID:20541849]
Caspase 7/Caspase-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3468] [GtoPdb: 1623] [UniProtKB: P55210]
ChEMBL	Inhibition of recombinant human caspase-7 activity using Ac-DEVD-AMC as substrate preincubated for 10 mins by fluorescence assay	B	6.81	pIC50	155.2	nM	IC50	Bioorg Med Chem (2014) 22: 6735-6745 [PMID:25468037]
ChEMBL	Inhibition of caspase-7 (unknown origin)	B	7.06	pIC50	87	nM	IC50	J Med Chem (2021) 64: 1786-1815 [PMID:33569941]
ChEMBL	Inhibitory activity against caspase-7	B	7.06	pIC50	87	nM	IC50	Bioorg Med Chem Lett (2004) 14: 805-808 [PMID:14741294]
ChEMBL	Inhibition of His-tagged human recombinant caspase 7 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay	B	7.22	pIC50	60.4	nM	IC50	Bioorg Med Chem Lett (2016) 26: 3195-3201 [PMID:27216999]
ChEMBL	Inhibition of human recombinant caspase 7 assessed as fluorescent 7-amido-4-methylcoumarin release	B	7.23	pIC50	59.1	nM	IC50	Eur J Med Chem (2010) 45: 3858-3863 [PMID:20541849]
ChEMBL	Inhibition of human recombinant caspase 7 assessed as accumulation of fluorogenic product by fluorometric assay	B	8.53	pIC50	2.95	nM	IC50	J Med Chem (2009) 52: 2188-2191 [PMID:19326941]
ChEMBL	Inhibition of caspase 7 by fluorometric assay	B	8.54	pIC50	2.9	nM	IC50	Bioorg Med Chem Lett (2011) 21: 2192-2197 [PMID:21441025]
Caspase 8/Caspase-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790]
ChEMBL	Inhibitory activity against caspase-8	B	6.89	pIC50	130	nM	IC50	Bioorg Med Chem Lett (2004) 14: 805-808 [PMID:14741294]
ChEMBL	Inhibition of caspase-8 (unknown origin)	B	6.89	pIC50	130	nM	IC50	J Med Chem (2021) 64: 1786-1815 [PMID:33569941]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]