Ac-DEVD-CHO [Ligand Id: 6527] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL417149
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
Caspase 1/Caspase-1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4801] [GtoPdb: 1617] [UniProtKB: P29466]
ChEMBL Amidolytic activity of THP.1 cell lysate against IL-1 beta converting enzyme using C1-Asp-AMC as a substrate B 4.15 pIC50 70000 nM IC50 Bioorg. Med. Chem. Lett. (1998) 8: 1477-1482 [PMID:9873373]
ChEMBL Inhibitory activity against caspase-1 B 6.72 pIC50 190 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 805-808 [PMID:14741294]
Caspase 3/Caspase-3 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2334] [GtoPdb: 1619] [UniProtKB: P42574]
ChEMBL Inhibition of recombinant human caspase-3 activity using Ac-DEVD-AMC as substrate preincubated for 10 mins by fluorescence assay B 7.12 pIC50 75.7 nM IC50 Bioorg. Med. Chem. (2014) 22: 6735-6745 [PMID:25468037]
ChEMBL Inhibitory concentration of compound against caspase-3 B 7.36 pIC50 43.9 nM IC50 J. Med. Chem. (2004) 47: 2466-2474 [PMID:15115390]
ChEMBL Inhibitory concentration required against human Caspase-3 B 7.57 pIC50 27 nM IC50 Bioorg. Med. Chem. Lett. (2003) 13: 2137-2140 [PMID:12798321]
ChEMBL Inhibitory activity against caspase-3 B 7.57 pIC50 27 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 805-808 [PMID:14741294]
ChEMBL Inhibition of caspase3 B 7.68 pIC50 21 nM IC50 J. Med. Chem. (2006) 49: 1613-1623 [PMID:16509578]
ChEMBL Inhibition of human recombinant caspase 3 assessed as accumulation of fluorogenic product by fluorometric assay B 8.66 pIC50 2.2 nM IC50 J. Med. Chem. (2009) 52: 2188-2191 [PMID:19326941]
ChEMBL Inhibition of human caspase 3 by fluorometric assay B 8.66 pIC50 2.2 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 2192-2197 [PMID:21441025]
ChEMBL Inhibition of His-tagged human recombinant caspase 3 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay B 8.77 pIC50 1.7 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3195-3201 [PMID:27216999]
ChEMBL Inhibition of human recombinant caspase 3 assessed as fluorescent 7-amido-4-methylcoumarin release B 8.8 pIC50 1.6 nM IC50 Eur. J. Med. Chem. (2010) 45: 3858-3863 [PMID:20541849]
ChEMBL Inhibition of recombinant human caspase-3 using Ac-LDEVD-AMC as substrate assessed as accumulation of 7-AMC incubated for 10 mins followed by substrate addition measured for 10 mins by fluorimetric analysis B 9.7 pIC50 0.2 nM IC50 Bioorg. Med. Chem. (2013) 21: 2960-2967 [PMID:23632366]
GtoPdb - - 9.8 pIC50 0.16 nM IC50 Eur J Med Chem (2010) 45: 3858-63 [PMID:20541849]
Caspase 7/Caspase-7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3468] [GtoPdb: 1623] [UniProtKB: P55210]
ChEMBL Inhibition of recombinant human caspase-7 activity using Ac-DEVD-AMC as substrate preincubated for 10 mins by fluorescence assay B 6.81 pIC50 155.2 nM IC50 Bioorg. Med. Chem. (2014) 22: 6735-6745 [PMID:25468037]
ChEMBL Inhibitory activity against caspase-7 B 7.06 pIC50 87 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 805-808 [PMID:14741294]
ChEMBL Inhibition of His-tagged human recombinant caspase 7 expressed in Escherichia coli using acetyl-Asp-Glu-Val-Asp-7- amido-4-methylcoumarin (Ac-DEVD-AMC) as substrate by fluorimetric assay B 7.22 pIC50 60.4 nM IC50 Bioorg. Med. Chem. Lett. (2016) 26: 3195-3201 [PMID:27216999]
ChEMBL Inhibition of human recombinant caspase 7 assessed as fluorescent 7-amido-4-methylcoumarin release B 7.23 pIC50 59.1 nM IC50 Eur. J. Med. Chem. (2010) 45: 3858-3863 [PMID:20541849]
ChEMBL Inhibition of human recombinant caspase 7 assessed as accumulation of fluorogenic product by fluorometric assay B 8.53 pIC50 2.95 nM IC50 J. Med. Chem. (2009) 52: 2188-2191 [PMID:19326941]
ChEMBL Inhibition of caspase 7 by fluorometric assay B 8.54 pIC50 2.9 nM IC50 Bioorg. Med. Chem. Lett. (2011) 21: 2192-2197 [PMID:21441025]
Caspase 8/Caspase-8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3776] [GtoPdb: 1624] [UniProtKB: Q14790]
ChEMBL Inhibitory activity against caspase-8 B 6.89 pIC50 130 nM IC50 Bioorg. Med. Chem. Lett. (2004) 14: 805-808 [PMID:14741294]

ChEMBL data shown on this page come from version 31:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, Cibrián-Uhalte E, Davies M, Dedman N, Karlsson A, Magariños MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]