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Caspase 7

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Target not currently curated in GtoImmuPdb

Target id: 1623

Nomenclature: Caspase 7

Family: C14: Caspase

Gene and Protein Information Click here for help
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 303 10q25.3 CASP7 caspase 7
Mouse - 303 19 51.84 cM Casp7 caspase 7
Rat - 303 1q55 Casp7 caspase 7
Previous and Unofficial Names Click here for help
apoptotic protease Mch-3 | CMH-1 | ICE-LAP3 | ICE-like apoptotic protease 3 | ICE-IAP3 | MCH3 | caspase 7, apoptosis-related cysteine peptidase
Database Links Click here for help
Specialist databases
MEROPS C14.004 (Hs)
Other databases
Alphafold
BRENDA
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
KEGG Gene
OMIM
Pharos
RefSeq Nucleotide
RefSeq Protein
UniProtKB
Wikipedia
Enzyme Reaction Click here for help
EC Number: 3.4.22.60
Substrates and Reaction Kinetics Click here for help
Substrate Sp. Property Value Units Standard property Standard value Assay description Assay conditions Comments Reference
huntingtin Substrate is endogenous in the given species Hs - -
retinoblastoma-associated protein Substrate is endogenous in the given species Hs - -
caspase 3 Substrate is endogenous in the given species Hs - -
ICAD Substrate is endogenous in the given species Hs - -
PARP Substrate is endogenous in the given species Hs - -
PKCδ Substrate is endogenous in the given species Hs - -
Pro-caspase 7 Substrate is endogenous in the given species Hs - -
Endogenous activators (Human)
Caspase 8, caspase 9, caspase 10, GrB

Download all structure-activity data for this target as a CSV file go icon to follow link

Inhibitors
Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
isatin sulfonamide 34 [PMID: 11384246] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 8.2 pKi 3
pKi 8.2 (Ki 6x10-9 M) [3]
compound 4 [PMID: 12408711] Small molecule or natural product Click here for species-specific activity table Hs Inhibition 6.9 pKi 1
pKi 6.9 (Ki 1.3x10-7 M) [1]
M826 Small molecule or natural product Click here for species-specific activity table Hs Inhibition 7.9 pIC50 2
pIC50 7.9 (IC50 1.3x10-8 M) [2]

References

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1. Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL et al.. (2002) Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem, 45 (23): 5005-22. [PMID:12408711]

2. Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J et al.. (2005) Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett, 15 (4): 1173-80. [PMID:15686936]

3. Lee D, Long SA, Murray JH, Adams JL, Nuttall ME, Nadeau DP, Kikly K, Winkler JD, Sung CM, Ryan MD et al.. (2001) Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem, 44 (12): 2015-26. [PMID:11384246]

How to cite this page

C14: Caspase: Caspase 7. Last modified on 27/07/2015. Accessed on 30/11/2021. IUPHAR/BPS Guide to PHARMACOLOGY, http://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1623.