Top ▲
Gene and Protein Information ![]() |
||||||
Species | TM | AA | Chromosomal Location | Gene Symbol | Gene Name | Reference |
Human | - | 303 | 10q25.3 | CASP7 | caspase 7 | |
Mouse | - | 303 | 19 51.84 cM | Casp7 | caspase 7 | |
Rat | - | 303 | 1q55 | Casp7 | caspase 7 |
Previous and Unofficial Names ![]() |
apoptotic protease Mch-3 | CMH-1 | ICE-LAP3 | ICE-like apoptotic protease 3 | ICE-IAP3 | MCH3 | caspase 7, apoptosis-related cysteine peptidase |
Database Links ![]() |
|
Specialist databases | |
MEROPS | C14.004 (Hs) |
Other databases | |
Alphafold | P55210 (Hs), P97864 (Mm) |
BRENDA | 3.4.22.60 |
ChEMBL Target | CHEMBL3468 (Hs) |
Ensembl Gene | ENSG00000165806 (Hs), ENSMUSG00000025076 (Mm), ENSRNOG00000056216 (Rn) |
Entrez Gene | 840 (Hs), 12369 (Mm), 64026 (Rn) |
Human Protein Atlas | ENSG00000165806 (Hs) |
KEGG Enzyme | 3.4.22.60 |
KEGG Gene | hsa:840 (Hs), mmu:12369 (Mm), rno:64026 (Rn) |
OMIM | 601761 (Hs) |
Pharos | P55210 (Hs) |
RefSeq Nucleotide | NM_001267056 (Hs), NM_001267058 (Hs), NM_033338 (Hs), NM_033339 (Hs), NM_033340 (Hs), NM_001227 (Hs), NM_001267057 (Hs), NM_007611 (Mm), NM_022260 (Rn) |
RefSeq Protein | NP_001253986 (Hs), NP_001253987 (Hs), NP_203124 (Hs), NP_203125 (Hs), NP_203126 (Hs), NP_001253985 (Hs), NP_001218 (Hs), NP_031637 (Mm), NP_071596 (Rn) |
UniProtKB | P55210 (Hs), P97864 (Mm) |
Wikipedia | CASP7 (Hs) |
Enzyme Reaction ![]() |
||||
|
Substrates and Reaction Kinetics ![]() |
||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
Endogenous activators (Human) |
Caspase 8, caspase 9, caspase 10, GrB |
Download all structure-activity data for this target as a CSV file
Inhibitors | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Key to terms and symbols | View all chemical structures | Click column headers to sort | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
|
1. Choong IC, Lew W, Lee D, Pham P, Burdett MT, Lam JW, Wiesmann C, Luong TN, Fahr B, DeLano WL et al.. (2002) Identification of potent and selective small-molecule inhibitors of caspase-3 through the use of extended tethering and structure-based drug design. J Med Chem, 45 (23): 5005-22. [PMID:12408711]
2. Han Y, Giroux A, Colucci J, Bayly CI, Mckay DJ, Roy S, Xanthoudakis S, Vaillancourt J, Rasper DM, Tam J et al.. (2005) Novel pyrazinone mono-amides as potent and reversible caspase-3 inhibitors. Bioorg Med Chem Lett, 15 (4): 1173-80. [PMID:15686936]
3. Lee D, Long SA, Murray JH, Adams JL, Nuttall ME, Nadeau DP, Kikly K, Winkler JD, Sung CM, Ryan MD et al.. (2001) Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem, 44 (12): 2015-26. [PMID:11384246]
C14: Caspase: Caspase 7. Last modified on 27/07/2015. Accessed on 14/02/2025. IUPHAR/BPS Guide to PHARMACOLOGY, https://www.guidetopharmacology.org/GRAC/ObjectDisplayForward?objectId=1623.