fisetin [Ligand Id: 5182] activity data from GtoPdb and ChEMBL

Click here for a description of the charts and data table

Please tell us if you are using this feature and what you think!

ChEMBL ligand: CHEMBL31574 (NSC-407010)
  • 3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
There should be some charts here, you may need to enable JavaScript!
  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
There should be some charts here, you may need to enable JavaScript!
  • Alpha-glucosidase MAL62 in Saccharomyces cerevisiae [ChEMBL: CHEMBL4357] [UniProtKB: P07265]
There should be some charts here, you may need to enable JavaScript!
  • 12S-LOX/Arachidonate 12-lipoxygenase in Human [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054]
There should be some charts here, you may need to enable JavaScript!
  • 15-LOX-1/Arachidonate 15-lipoxygenase in Human [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
There should be some charts here, you may need to enable JavaScript!
  • 15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
There should be some charts here, you may need to enable JavaScript!
  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
There should be some charts here, you may need to enable JavaScript!
  • cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534]
There should be some charts here, you may need to enable JavaScript!
  • Enoyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
There should be some charts here, you may need to enable JavaScript!
  • Fatty acid synthase in Plasmodium falciparum [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
There should be some charts here, you may need to enable JavaScript!
  • Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
There should be some charts here, you may need to enable JavaScript!
  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
There should be some charts here, you may need to enable JavaScript!
  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
There should be some charts here, you may need to enable JavaScript!
  • xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
There should be some charts here, you may need to enable JavaScript!
DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
ChEMBL Inhibition of FabG B 5.39 pIC50 4100 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Inhibition of AChE (unknown origin) B 7.92 pIC50 12 nM IC50 Med Chem Res (2013) 22: 3061-3075
Alpha-glucosidase MAL62 in Saccharomyces cerevisiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4357] [UniProtKB: P07265]
ChEMBL Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry B 1.11 pIC50 1.11 - logIC50 Med Chem Res (2012) 21: 3984-3993
12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054]
ChEMBL Inhibition of 12-hLO B 6.02 pIC50 950 nM IC50 Bioorg. Med. Chem. (2007) 15: 7408-7425 [PMID:17869117]
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
ChEMBL Inhibition of 15-hLO1 B 5.85 pIC50 1400 nM IC50 Bioorg. Med. Chem. (2007) 15: 7408-7425 [PMID:17869117]
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
ChEMBL Inhibition of 15-hLO2 B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2007) 15: 7408-7425 [PMID:17869117]
Arginase I/Arginase-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232699] [GtoPdb: 1244] [UniProtKB: P07824]
ChEMBL Inhibition of recombinant rat liver arginase expressed without histidine tail assessed as urea formation using L-arginine as substrate after 15 mins by Berthelot assay B 5.85 pIC50 1400 nM IC50 MedChemComm (2016) 7: 214-223
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of human plasma BChE by Ellman's method B 4.05 pKi 90000 nM Ki Eur. J. Med. Chem. (2010) 45: 186-192 [PMID:19879672]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
ChEMBL Inhibition of CK2 (unknown origin) B 6.77 pKi 170 nM Ki Eur. J. Med. Chem. (2016) 115: 148-160 [PMID:27017545]
ChEMBL Inhibition of recombinant human CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins B 6 pIC50 <1000 nM IC50 J. Med. Chem. (2015) 58: 7400-7408 [PMID:26322379]
ChEMBL Inhibition of CK2 (unknown origin) B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. (2013) 21: 6681-6689 [PMID:24011954]
Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
ChEMBL Inhibition of Trypanosoma cruzi cruzain by quantitative high throughput screening B 4.22 pIC50 >60000 nM IC50 J. Med. Chem. (2010) 53: 37-51 [PMID:19908840]
ChEMBL Inhibition of Trypanosoma cruzi cruzain by Flexstation microplate spectrofluorimetry B 4.52 pIC50 30000 nM IC50 J. Med. Chem. (2010) 53: 37-51 [PMID:19908840]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067P06493P14635Q8WWL7]
ChEMBL Inhibition of cyclin-dependent kinase 1/cyclinB B 6.1 pIC50 790 nM IC50 J. Med. Chem. (2005) 48: 737-743 [PMID:15689157]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of CDK2 B 5.3 pIC50 5000 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 1284-1287 [PMID:17178224]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
ChEMBL Inhibition of Cyclin-dependent kinase 5-p25nck5a B 6.24 pIC50 570 nM IC50 J. Med. Chem. (2005) 48: 737-743 [PMID:15689157]
cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534]
ChEMBL Inhibition of human cyclin-dependent kinase 6 complex with a virus-encoded cyclin from herpesvirus saimiri (Vcyclin) B 6.07 pIC50 850 nM IC50 J. Med. Chem. (2005) 48: 737-743 [PMID:15689157]
ChEMBL Inhibition of Homo sapiens (human) cyclin-dependent kinase 6 B 6.07 pIC50 850 nM IC50 Med Chem Res (2010) 19: 817-835
Enoyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
ChEMBL Inhibition of FabI B 6 pIC50 1000 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
ChEMBL Inhibition of Plasmodium falciparum FabI B 6 pIC50 1000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4779-4781 [PMID:20637612]
Fatty acid synthase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
ChEMBL Inhibition of FabZ B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
ChEMBL IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavage B 4.55 pIC50 28400 nM IC50 J. Med. Chem. (1995) 38: 890-897 [PMID:7699704]
ChEMBL IC50 was measured as concentration required to inhibit 50% of HIV-integrase integration B 5.07 pIC50 8500 nM IC50 J. Med. Chem. (1995) 38: 890-897 [PMID:7699704]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 F 5.09 pIC50 8200 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 F 5.09 pIC50 8200 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4779-4781 [PMID:20637612]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 F 5.19 pIC50 6500 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
Salivary alpha-amylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2478] [UniProtKB: P04745]
ChEMBL Inhibition of human salivary alpha-amylase B 4.71 pIC50 19600 nM IC50 J. Med. Chem. (2008) 51: 3555-3561 [PMID:18507367]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Inhibition of PIM1 kinase B 0.07 pIC50 0.07 uM -Log IC50 Bioorg. Med. Chem. (2007) 15: 6463-6473 [PMID:17637507]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Inhibition of SYK B 4.82 pIC50 15000 nM IC50 J. Med. Chem. (2012) 55: 3614-3643 [PMID:22257213]
ChEMBL Inhibition of SYK in human mast cells assessed as reduction in mast cell degranulation B 4.72 pEC50 19000 nM EC50 J. Med. Chem. (2012) 55: 3614-3643 [PMID:22257213]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry B 5.36 pIC50 4330 nM IC50 J. Nat. Prod. (1998) 61: 71-76 [PMID:9461655]

ChEMBL data shown on this page come from version 27:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]