ChEMBL ligand: CHEMBL31574 (5-desoxyquercetin, C.i. 75620, C.i. natural brown 1, Fisetin, Fisidenolon 1521, NSC-407010, NSC-656275)
3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6] There should be some charts here, you may need to enable JavaScript!
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303] There should be some charts here, you may need to enable JavaScript!
Alpha-glucosidase MAL62 in Saccharomyces cerevisiae [ChEMBL: CHEMBL4357] [UniProtKB: P07265] There should be some charts here, you may need to enable JavaScript!
Amyloid-beta A4 protein in Human [ChEMBL: CHEMBL2487] [UniProtKB: P05067] There should be some charts here, you may need to enable JavaScript!
12S-LOX/Arachidonate 12-lipoxygenase in Human [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054] There should be some charts here, you may need to enable JavaScript!
15-LOX-1/Arachidonate 15-lipoxygenase in Human [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050] There should be some charts here, you may need to enable JavaScript!
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296] There should be some charts here, you may need to enable JavaScript!
Arginase I/Arginase-1 in Rat [ChEMBL: CHEMBL3232699] [GtoPdb: 1244] [UniProtKB: P07824] There should be some charts here, you may need to enable JavaScript!
butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400] There should be some charts here, you may need to enable JavaScript!
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400] There should be some charts here, you may need to enable JavaScript!
Cruzipain in Trypanosoma cruzi [ChEMBL: CHEMBL3563] [UniProtKB: P25779] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078] There should be some charts here, you may need to enable JavaScript!
cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534] There should be some charts here, you may need to enable JavaScript!
Enoyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5] There should be some charts here, you may need to enable JavaScript!
Fatty acid synthase in Plasmodium falciparum [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7] There should be some charts here, you may need to enable JavaScript!
Glyoxalase I in Human [ChEMBL: CHEMBL2424] [UniProtKB: Q04760] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1] There should be some charts here, you may need to enable JavaScript!
Plasmodium falciparum [ChEMBL: CHEMBL364] There should be some charts here, you may need to enable JavaScript!
pyruvate kinase M1/2/Pyruvate kinase isozymes M1/M2 in Human [ChEMBL: CHEMBL1075189] [GtoPdb: 3006] [UniProtKB: P14618] There should be some charts here, you may need to enable JavaScript!
Salivary alpha-amylase in Human [ChEMBL: CHEMBL2478] [UniProtKB: P0DUB6] There should be some charts here, you may need to enable JavaScript!
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309] There should be some charts here, you may need to enable JavaScript!
OATP2B1/Solute carrier organic anion transporter family member 2B1 in Human [ChEMBL: CHEMBL1743124] [GtoPdb: 1224] [UniProtKB: O94956] There should be some charts here, you may need to enable JavaScript!
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405] There should be some charts here, you may need to enable JavaScript!
xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
ChEMBL	Inhibition of FabG	B	5.39	pIC50	4100	nM	IC50	J Med Chem (2006) 49: 3345-3353 [PMID:16722653]
acetylcholinesterase (Yt blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL	Inhibition of AChE (unknown origin)	B	7.92	pIC50	12	nM	IC50	Med Chem Res (2013) 22: 3061-3075
Alpha-glucosidase MAL62 in Saccharomyces cerevisiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4357] [UniProtKB: P07265]
ChEMBL	Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry	B	1.11	pIC50	1.11	-	logIC50	Med Chem Res (2012) 21: 3984-3993
Amyloid-beta A4 protein in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2487] [UniProtKB: P05067]
ChEMBL	Inhibition of amyloid beta (1 to 42) (unknown origin) fibril formation incubated for 1 hr by thioflavin-T fluorescence assay	B	4.9	pIC50	12500	nM	IC50	Eur J Med Chem (2018) 152: 570-589 [PMID:29763806]
12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054]
ChEMBL	Inhibition of 12-hLO	B	6.02	pIC50	950	nM	IC50	Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117]
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
ChEMBL	Inhibition of 15-hLO1	B	5.85	pIC50	1400	nM	IC50	Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117]
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
ChEMBL	Inhibition of 15-hLO2	B	4	pIC50	>100000	nM	IC50	Bioorg Med Chem (2007) 15: 7408-7425 [PMID:17869117]
Arginase I/Arginase-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232699] [GtoPdb: 1244] [UniProtKB: P07824]
ChEMBL	Inhibition of recombinant rat liver arginase expressed without histidine tail assessed as urea formation using L-arginine as substrate after 15 mins by Berthelot assay	B	5.85	pIC50	1400	nM	IC50	Medchemcomm (2016) 7: 214-223
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL	Inhibition of human plasma BChE by Ellman's method	B	4.05	pKi	90000	nM	Ki	Eur J Med Chem (2010) 45: 186-192 [PMID:19879672]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 1550, 1551, 1549] [UniProtKB: P19784, P67870, P68400]
ChEMBL	Inhibition of CK2 (unknown origin)	B	6.77	pKi	170	nM	Ki	Eur J Med Chem (2016) 115: 148-160 [PMID:27017545]
ChEMBL	Inhibition of recombinant human CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins	B	6	pIC50	<1000	nM	IC50	J Med Chem (2015) 58: 7400-7408 [PMID:26322379]
ChEMBL	Inhibition of CK2 (unknown origin)	B	6.46	pIC50	350	nM	IC50	Bioorg Med Chem (2013) 21: 6681-6689 [PMID:24011954]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL	Inhibition of CK2alpha (unknown origin)	B	6.46	pKi	350	nM	Ki	Eur J Med Chem (2019) 181: 111581-111581 [PMID:31400711]
Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
ChEMBL	Inhibition of Trypanosoma cruzi cruzain by quantitative high throughput screening	B	4.22	pIC50	>60000	nM	IC50	J Med Chem (2010) 53: 37-51 [PMID:19908840]
ChEMBL	Inhibition of Trypanosoma cruzi cruzain by Flexstation microplate spectrofluorimetry	B	4.52	pIC50	30000	nM	IC50	J Med Chem (2010) 53: 37-51 [PMID:19908840]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067, P06493, P14635, Q8WWL7]
ChEMBL	Inhibition of cyclin-dependent kinase 1/cyclinB	B	6.1	pIC50	790	nM	IC50	J Med Chem (2005) 48: 737-743 [PMID:15689157]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL	Inhibition of CDK2	B	5.3	pIC50	5000	nM	IC50	Bioorg Med Chem Lett (2007) 17: 1284-1287 [PMID:17178224]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535, Q15078]
ChEMBL	Inhibition of Cyclin-dependent kinase 5-p25nck5a	B	6.24	pIC50	570	nM	IC50	J Med Chem (2005) 48: 737-743 [PMID:15689157]
cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534]
ChEMBL	Inhibition of human cyclin-dependent kinase 6 complex with a virus-encoded cyclin from herpesvirus saimiri (Vcyclin)	B	6.07	pIC50	850	nM	IC50	J Med Chem (2005) 48: 737-743 [PMID:15689157]
ChEMBL	Inhibition of Homo sapiens (human) cyclin-dependent kinase 6	B	6.07	pIC50	850	nM	IC50	Med Chem Res (2010) 19: 817-835
Enoyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
ChEMBL	Inhibition of FabI	B	6	pIC50	1000	nM	IC50	J Med Chem (2006) 49: 3345-3353 [PMID:16722653]
ChEMBL	Inhibition of Plasmodium falciparum FabI	B	6	pIC50	1000	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4779-4781 [PMID:20637612]
Fatty acid synthase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
ChEMBL	Inhibition of FabZ	B	5.7	pIC50	2000	nM	IC50	J Med Chem (2006) 49: 3345-3353 [PMID:16722653]
Glyoxalase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424] [UniProtKB: Q04760]
ChEMBL	Inhibition constant of compound against binding of Yeast Glyoxalase I	B	4.88	pKi	13182.57	nM	Ki	J Med Chem (1988) 31: 1396-1406 [PMID:3290487]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate	B	5.64	pIC50	2308	nM	IC50	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
ChEMBL	IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavage	B	4.55	pIC50	28400	nM	IC50	J Med Chem (1995) 38: 890-897 [PMID:7699704]
ChEMBL	IC50 was measured as concentration required to inhibit 50% of HIV-integrase integration	B	5.07	pIC50	8500	nM	IC50	J Med Chem (1995) 38: 890-897 [PMID:7699704]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL	Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	5.09	pIC50	8200	nM	IC50	J Med Chem (2006) 49: 3345-3353 [PMID:16722653]
ChEMBL	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54	F	5.09	pIC50	8200	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4779-4781 [PMID:20637612]
ChEMBL	Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1	F	5.19	pIC50	6500	nM	IC50	J Med Chem (2006) 49: 3345-3353 [PMID:16722653]
pyruvate kinase M1/2/Pyruvate kinase isozymes M1/M2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1075189] [GtoPdb: 3006] [UniProtKB: P14618]
ChEMBL	Inhibition of recombinant PKM2 (unknown origin) Gly128, Asp177, Asp178, Ser362, Hie78, Be51, Asn75 residues	B	6.05	pIC50	900	nM	IC50	J Med Chem (2022) 65: 1171-1205 [PMID:34726055]
ChEMBL	Inhibition of PKM2 (unknown origin)	B	6.05	pIC50	900	nM	IC50	RSC Med Chem (2021) 12: 1121-1141 [PMID:34355179]
Salivary alpha-amylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2478] [UniProtKB: P0DUB6]
ChEMBL	Inhibition of human salivary alpha-amylase	B	4.71	pIC50	19600	nM	IC50	J Med Chem (2008) 51: 3555-3561 [PMID:18507367]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL	Inhibition of PIM1 kinase	B	0.07	pIC50	0.07	uM	-Log IC50	Bioorg Med Chem (2007) 15: 6463-6473 [PMID:17637507]
OATP2B1/Solute carrier organic anion transporter family member 2B1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1743124] [GtoPdb: 1224] [UniProtKB: O94956]
ChEMBL	Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of OATP2B1 mediated DBF uptake using DBF as fluorescent substrate incubated for 2 mins by BCA assay	B	5.17	pIC50	6760.83	nM	IC50	RSC Med Chem (2023) 14: 890-898 [PMID:37252098]
ChEMBL	Inhibition of human OATP2B1 expressed in Flp-In-CHO cells assessed as inhibition of OATP2B1 mediated DBF uptake using DBF as fluorescent substrate incubated for 2 mins by BCA assay	B	5.17	pIC50	6700	nM	IC50	RSC Med Chem (2023) 14: 890-898 [PMID:37252098]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL	Inhibition of SYK	B	4.82	pIC50	15000	nM	IC50	J Med Chem (2012) 55: 3614-3643 [PMID:22257213]
ChEMBL	Inhibition of SYK in human mast cells assessed as reduction in mast cell degranulation	B	4.72	pEC50	19000	nM	EC50	J Med Chem (2012) 55: 3614-3643 [PMID:22257213]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL	Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry	B	5.36	pIC50	4330	nM	IC50	J Nat Prod (1998) 61: 71-76 [PMID:9461655]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]