fisetin [Ligand Id: 5182] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL31574 (NSC-656275, NSC-407010, Fisetin)
  • 3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
  • This target only has 0 pki data point
  • 0
1 CHEMBL31574_lig_chart_1 3-oxoacyl-acyl-carrier protein reductase Plasmodium falciparum
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  • acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
  • This target only has 0 pki data point
  • 0
2 CHEMBL31574_lig_chart_2 Acetylcholinesterase Human
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  • Alpha-glucosidase MAL62 in Saccharomyces cerevisiae [ChEMBL: CHEMBL4357] [UniProtKB: P07265]
  • This target only has 0 pki data point
  • 0
3 CHEMBL31574_lig_chart_3 Alpha-glucosidase MAL62 Saccharomyces cerevisiae
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  • 12S-LOX/Arachidonate 12-lipoxygenase in Human [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054]
  • This target only has 0 pki data point
  • 0
4 CHEMBL31574_lig_chart_4 Arachidonate 12-lipoxygenase Human
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  • 15-LOX-1/Arachidonate 15-lipoxygenase in Human [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
  • This target only has 0 pki data point
  • 0
5 CHEMBL31574_lig_chart_5 Arachidonate 15-lipoxygenase Human
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  • 15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
  • This target only has 0 pki data point
  • 0
6 CHEMBL31574_lig_chart_6 Arachidonate 15-lipoxygenase, type II Human
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  • Arginase I/Arginase-1 in Rat [ChEMBL: CHEMBL3232699] [GtoPdb: 1244] [UniProtKB: P07824]
  • This target only has 0 pki data point
  • 0
7 CHEMBL31574_lig_chart_7 Arginase-1 Rat
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  • butyrylcholinesterase/Butyrylcholinesterase in Human [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
  • This target only has 1 pki data point
  • 4.05
8 CHEMBL31574_lig_chart_8 Butyrylcholinesterase Human
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  • casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
  • This target only has 1 pki data point
  • 6.77
9 CHEMBL31574_lig_chart_9 Casein kinase II Human
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  • casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
  • This target only has 1 pki data point
  • 6.46
10 CHEMBL31574_lig_chart_10 Casein kinase II alpha Human
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  • Cruzipain in Trypanosoma cruzi [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
  • This target only has 0 pki data point
  • 0
11 CHEMBL31574_lig_chart_11 Cruzipain Trypanosoma cruzi
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12 CHEMBL31574_lig_chart_12 Cyclin-dependent kinase 1/cyclin B Human
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  • cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
  • This target only has 0 pki data point
  • 0
13 CHEMBL31574_lig_chart_13 Cyclin-dependent kinase 2 Human
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  • cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
  • This target only has 0 pki data point
  • 0
14 CHEMBL31574_lig_chart_14 Cyclin-dependent kinase 5/CDK5 activator 1 Human
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  • cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534]
  • This target only has 0 pki data point
  • 0
15 CHEMBL31574_lig_chart_15 Cyclin-dependent kinase 6 Human
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  • Enoyl-acyl-carrier protein reductase in Plasmodium falciparum [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
  • This target only has 0 pki data point
  • 0
16 CHEMBL31574_lig_chart_16 Enoyl-acyl-carrier protein reductase Plasmodium falciparum
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  • Fatty acid synthase in Plasmodium falciparum [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
  • This target only has 0 pki data point
  • 0
17 CHEMBL31574_lig_chart_17 Fatty acid synthase Plasmodium falciparum
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  • Glyoxalase I in Human [ChEMBL: CHEMBL2424] [UniProtKB: Q04760]
  • This target only has 1 pki data point
  • 4.88
18 CHEMBL31574_lig_chart_18 Glyoxalase I Human
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  • Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
  • This target only has 0 pki data point
  • 0
19 CHEMBL31574_lig_chart_19 Human immunodeficiency virus type 1 integrase Human immunodeficiency virus 1
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  • Plasmodium falciparum [ChEMBL: CHEMBL364]
  • This target only has 0 pki data point
  • 0
20 CHEMBL31574_lig_chart_20 Plasmodium falciparum Plasmodium falciparum
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  • Salivary alpha-amylase in Human [ChEMBL: CHEMBL2478] [UniProtKB: P0DUB6]
  • This target only has 0 pki data point
  • 0
21 CHEMBL31574_lig_chart_21 Salivary alpha-amylase Human
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  • Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
  • This target only has 0 pki data point
  • 0
22 CHEMBL31574_lig_chart_22 Serine/threonine-protein kinase PIM1 Human
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  • spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
  • This target only has 0 pki data point
  • 0
23 CHEMBL31574_lig_chart_23 Tyrosine-protein kinase SYK Human
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  • xanthine dehydrogenase/Xanthine dehydrogenase in Human [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
  • This target only has 0 pki data point
  • 0
24 CHEMBL31574_lig_chart_24 Xanthine dehydrogenase Human
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
3-oxoacyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4513] [UniProtKB: Q965D6]
ChEMBL Inhibition of FabG B 5.39 pIC50 4100 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
acetylcholinesterase (Cartwright blood group)/Acetylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL220] [GtoPdb: 2465] [UniProtKB: P22303]
ChEMBL Inhibition of AChE (unknown origin) B 7.92 pIC50 12 nM IC50 Med Chem Res (2013) 22: 3061-3075
Alpha-glucosidase MAL62 in Saccharomyces cerevisiae (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4357] [UniProtKB: P07265]
ChEMBL Inhibition of baker's yeast alpha-glucosidase using p-nitrophenyl-alpha-D-glucopyranoside as substrate by spectrophotometry B 1.11 pIC50 1.11 - logIC50 Med Chem Res (2012) 21: 3984-3993
12S-LOX/Arachidonate 12-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3687] [GtoPdb: 1387] [UniProtKB: P18054]
ChEMBL Inhibition of 12-hLO B 6.02 pIC50 950 nM IC50 Bioorg. Med. Chem. (2007) 15: 7408-7425 [PMID:17869117]
15-LOX-1/Arachidonate 15-lipoxygenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2903] [GtoPdb: 1388] [UniProtKB: P16050]
ChEMBL Inhibition of 15-hLO1 B 5.85 pIC50 1400 nM IC50 Bioorg. Med. Chem. (2007) 15: 7408-7425 [PMID:17869117]
15-LOX-2/Arachidonate 15-lipoxygenase, type II in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2457] [GtoPdb: 1389] [UniProtKB: O15296]
ChEMBL Inhibition of 15-hLO2 B 4 pIC50 >100000 nM IC50 Bioorg. Med. Chem. (2007) 15: 7408-7425 [PMID:17869117]
Arginase I/Arginase-1 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3232699] [GtoPdb: 1244] [UniProtKB: P07824]
ChEMBL Inhibition of recombinant rat liver arginase expressed without histidine tail assessed as urea formation using L-arginine as substrate after 15 mins by Berthelot assay B 5.85 pIC50 1400 nM IC50 MedChemComm (2016) 7: 214-223
butyrylcholinesterase/Butyrylcholinesterase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1914] [GtoPdb: 2471] [UniProtKB: P06276]
ChEMBL Inhibition of human plasma BChE by Ellman's method B 4.05 pKi 90000 nM Ki Eur. J. Med. Chem. (2010) 45: 186-192 [PMID:19879672]
casein kinase 2, alpha prime polypeptide subunit/casein kinase 2, beta polypeptide subunit/casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II in Human (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL2095191] [GtoPdb: 155015511549] [UniProtKB: P19784P67870P68400]
ChEMBL Inhibition of CK2 (unknown origin) B 6.77 pKi 170 nM Ki Eur. J. Med. Chem. (2016) 115: 148-160 [PMID:27017545]
ChEMBL Inhibition of recombinant human CK2 expressed in Escherichia coli using RRRADDSDDDDD as substrate after 10 mins B 6 pIC50 <1000 nM IC50 J. Med. Chem. (2015) 58: 7400-7408 [PMID:26322379]
ChEMBL Inhibition of CK2 (unknown origin) B 6.46 pIC50 350 nM IC50 Bioorg. Med. Chem. (2013) 21: 6681-6689 [PMID:24011954]
casein kinase 2, alpha 1 polypeptide subunit/Casein kinase II alpha in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3629] [GtoPdb: 1549] [UniProtKB: P68400]
ChEMBL Inhibition of CK2alpha (unknown origin) B 6.46 pKi 350 nM Ki Eur J Med Chem (2019) 181: 111581-111581 [PMID:31400711]
Cruzipain in Trypanosoma cruzi (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3563] [UniProtKB: P25779]
ChEMBL Inhibition of Trypanosoma cruzi cruzain by quantitative high throughput screening B 4.22 pIC50 >60000 nM IC50 J. Med. Chem. (2010) 53: 37-51 [PMID:19908840]
ChEMBL Inhibition of Trypanosoma cruzi cruzain by Flexstation microplate spectrofluorimetry B 4.52 pIC50 30000 nM IC50 J. Med. Chem. (2010) 53: 37-51 [PMID:19908840]
cyclin dependent kinase 1/Cyclin-dependent kinase 1/cyclin B in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL2094127] [GtoPdb: 1961] [UniProtKB: O95067P06493P14635Q8WWL7]
ChEMBL Inhibition of cyclin-dependent kinase 1/cyclinB B 6.1 pIC50 790 nM IC50 J. Med. Chem. (2005) 48: 737-743 [PMID:15689157]
cyclin dependent kinase 2/Cyclin-dependent kinase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL301] [GtoPdb: 1973] [UniProtKB: P24941]
ChEMBL Inhibition of CDK2 B 5.3 pIC50 5000 nM IC50 Bioorg. Med. Chem. Lett. (2007) 17: 1284-1287 [PMID:17178224]
cyclin dependent kinase 5/Cyclin-dependent kinase 5/CDK5 activator 1 in Human (target type: PROTEIN COMPLEX) [ChEMBL: CHEMBL1907600] [GtoPdb: 1977] [UniProtKB: Q00535Q15078]
ChEMBL Inhibition of Cyclin-dependent kinase 5-p25nck5a B 6.24 pIC50 570 nM IC50 J. Med. Chem. (2005) 48: 737-743 [PMID:15689157]
cyclin dependent kinase 6/Cyclin-dependent kinase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2508] [GtoPdb: 1978] [UniProtKB: Q00534]
ChEMBL Inhibition of human cyclin-dependent kinase 6 complex with a virus-encoded cyclin from herpesvirus saimiri (Vcyclin) B 6.07 pIC50 850 nM IC50 J. Med. Chem. (2005) 48: 737-743 [PMID:15689157]
ChEMBL Inhibition of Homo sapiens (human) cyclin-dependent kinase 6 B 6.07 pIC50 850 nM IC50 Med Chem Res (2010) 19: 817-835
Enoyl-acyl-carrier protein reductase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4150] [UniProtKB: Q965D5]
ChEMBL Inhibition of FabI B 6 pIC50 1000 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
ChEMBL Inhibition of Plasmodium falciparum FabI B 6 pIC50 1000 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4779-4781 [PMID:20637612]
Fatty acid synthase in Plasmodium falciparum (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4512] [UniProtKB: Q965D7]
ChEMBL Inhibition of FabZ B 5.7 pIC50 2000 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
Glyoxalase I in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2424] [UniProtKB: Q04760]
ChEMBL Inhibition constant of compound against binding of Yeast Glyoxalase I B 4.88 pKi 13182.57 nM Ki J. Med. Chem. (1988) 31: 1396-1406 [PMID:3290487]
Human immunodeficiency virus type 1 integrase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3471] [UniProtKB: Q7ZJM1]
ChEMBL IC50 was measured as concentration required to inhibit 50% of HIV-integrase cleavage B 4.55 pIC50 28400 nM IC50 J. Med. Chem. (1995) 38: 890-897 [PMID:7699704]
ChEMBL IC50 was measured as concentration required to inhibit 50% of HIV-integrase integration B 5.07 pIC50 8500 nM IC50 J. Med. Chem. (1995) 38: 890-897 [PMID:7699704]
Plasmodium falciparum (target type: ORGANISM) [ChEMBL: CHEMBL364]
ChEMBL Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 F 5.09 pIC50 8200 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
ChEMBL Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 F 5.09 pIC50 8200 nM IC50 Bioorg. Med. Chem. Lett. (2010) 20: 4779-4781 [PMID:20637612]
ChEMBL Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 F 5.19 pIC50 6500 nM IC50 J. Med. Chem. (2006) 49: 3345-3353 [PMID:16722653]
Salivary alpha-amylase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2478] [UniProtKB: P0DUB6]
ChEMBL Inhibition of human salivary alpha-amylase B 4.71 pIC50 19600 nM IC50 J. Med. Chem. (2008) 51: 3555-3561 [PMID:18507367]
Pim-1 proto-oncogene, serine/threonine kinase/Serine/threonine-protein kinase PIM1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2147] [GtoPdb: 2158] [UniProtKB: P11309]
ChEMBL Inhibition of PIM1 kinase B 0.07 pIC50 0.07 uM -Log IC50 Bioorg. Med. Chem. (2007) 15: 6463-6473 [PMID:17637507]
spleen associated tyrosine kinase/Tyrosine-protein kinase SYK in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2599] [GtoPdb: 2230] [UniProtKB: P43405]
ChEMBL Inhibition of SYK B 4.82 pIC50 15000 nM IC50 J. Med. Chem. (2012) 55: 3614-3643 [PMID:22257213]
ChEMBL Inhibition of SYK in human mast cells assessed as reduction in mast cell degranulation B 4.72 pEC50 19000 nM EC50 J. Med. Chem. (2012) 55: 3614-3643 [PMID:22257213]
xanthine dehydrogenase/Xanthine dehydrogenase in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1929] [GtoPdb: 2646] [UniProtKB: P47989]
ChEMBL Inhibition of xanthine oxidase assessed as decrease in uric acid production by spectrophotometry B 5.36 pIC50 4330 nM IC50 J. Nat. Prod. (1998) 61: 71-76 [PMID:9461655]

ChEMBL data shown on this page come from version 28:

Gaulton A, Hersey A, Nowotka M, Bento AP, Chambers J, Mendez D, Mutowo P, Atkinson F, Bellis LJ, CibriƔn-Uhalte E, Davies M, Dedman N, Karlsson A, MagariƱos MP, Overington JP, Papadatos G, Smit I, Leach AR. (2017) 'The ChEMBL database in 2017.' Nucleic Acids Res., 45(D1). DOI: 10.1093/nar/gkw1074. [PMCID:5210557]