(R,S)-4-PPG [Ligand Id: 1406] activity data from GtoPdb and ChEMBL

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ChEMBL ligand: CHEMBL277475
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  • mGlu4 receptor/Metabotropic glutamate receptor 4 in Human [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833]
  • mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423]
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  • mGlu6 receptor/Metabotropic glutamate receptor 6 in Human [ChEMBL: CHEMBL4573] [GtoPdb: 294] [UniProtKB: O15303]
  • mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349]
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  • mGlu7 receptor/Metabotropic glutamate receptor 7 in Human [ChEMBL: CHEMBL3777] [GtoPdb: 295] [UniProtKB: Q14831]
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  • mGlu8 receptor/Metabotropic glutamate receptor 8 in Human [ChEMBL: CHEMBL3228] [GtoPdb: 296] [UniProtKB: O00222]
  • mGlu8 receptor/Metabotropic glutamate receptor 8 in Rat [ChEMBL: CHEMBL2718] [GtoPdb: 296] [UniProtKB: P70579]
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DB Assay description Assay Type Standard value Standard parameter Original value Original units Original parameter Reference
GluN1/GluN2A/GluN2B/GluN2C/GluN2D/GluN3B/GluN3A/Glutamate NMDA receptor in Rat (target type: PROTEIN COMPLEX GROUP) [ChEMBL: CHEMBL1907608] [GtoPdb: 455, 456, 457, 458, 459, 461, 460] [UniProtKB: P35439, Q00959, Q00960, Q00961, Q62645, Q8VHN2, Q9R1M7]
ChEMBL Displacement of [3H]CPP from N-methyl-D-aspartate glutamate receptor in rat brain membrane B 4 pIC50 >100000 nM IC50 J Med Chem (1992) 35: 1345-1370 [PMID:1533422]
mGlu4 receptor/Metabotropic glutamate receptor 4 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2736] [GtoPdb: 292] [UniProtKB: Q14833]
ChEMBL Agonist potency against cloned human Metabotropic glutamate receptor 4 (mGluR-4) F 5.28 pKi 5200 nM Ki J Med Chem (2000) 43: 2609-2645 [PMID:10893301]
ChEMBL Compound was evaluated for the inhibition of forskolin stimulated cAMP accumulation in CHO cells expressing hmGluR4a F 5.28 pEC50 5200 nM EC50 Bioorg Med Chem Lett (2000) 10: 1241-1244 [PMID:10866390]
GtoPdb - - 5.3 pEC50 - - - J Pharmacol Exp Ther (1999) 289: 1678-1687 [PMID:10336568];
Bioorg Med Chem Lett (2000) 10: 1241-4 [PMID:10866390]
ChEMBL Agonistic activity at Metabotropic glutamate receptor 4 expressed in mammalian cells by GTPgammaS binding assay B 5.33 pEC50 4700 nM EC50 Bioorg Med Chem Lett (2000) 10: 1447-1450 [PMID:10888329]
ChEMBL Compound was evaluated for the inhibition of forskolin stimulated cAMP accumulation in CHO cells expressing hmGluR4a F 5.49 pEC50 3200 nM EC50 Bioorg Med Chem Lett (2000) 10: 1241-1244 [PMID:10866390]
mGlu4 receptor/Metabotropic glutamate receptor 4 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2787] [GtoPdb: 292] [UniProtKB: P31423]
ChEMBL Metabotropic glutamate receptor 4 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells F 5.28 pEC50 5200 nM EC50 J Med Chem (2004) 47: 456-466 [PMID:14711315]
mGlu6 receptor/Metabotropic glutamate receptor 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL4573] [GtoPdb: 294] [UniProtKB: O15303]
ChEMBL Agonist potency against cloned Metabotropic glutamate receptor 6 (mGluR-6). F 5.33 pKi 4700 nM Ki J Med Chem (2000) 43: 2609-2645 [PMID:10893301]
GtoPdb - - 5.3 pEC50 - - - J Pharmacol Exp Ther (1999) 289: 1678-1687 [PMID:10336568];
Neuropharmacology (2001) 40: 311-8 [PMID:11166323]
mGlu6 receptor/Metabotropic glutamate receptor 6 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3842] [GtoPdb: 294] [UniProtKB: P35349]
ChEMBL Metabotropic glutamate receptor 6 agonist activity to influence forskolin stimulated c-AMP formation in rat non neuronal cells F 5.33 pEC50 4700 nM EC50 J Med Chem (2004) 47: 456-466 [PMID:14711315]
mGlu7 receptor/Metabotropic glutamate receptor 7 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3777] [GtoPdb: 295] [UniProtKB: Q14831]
GtoPdb - - 3.7 pIC50 - - - J Pharmacol Exp Ther (1999) 289: 1678-1687 [PMID:10336568];
Bioorg Med Chem Lett (2000) 10: 1241-4 [PMID:10866390]
ChEMBL Compound was evaluated for the inhibition of forskolin stimulated cAMP accumulation in CHO cells expressing hmGluR7b F 4.32 pEC50 48000 nM EC50 Bioorg Med Chem Lett (2000) 10: 1241-1244 [PMID:10866390]
mGlu8 receptor/Metabotropic glutamate receptor 8 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3228] [GtoPdb: 296] [UniProtKB: O00222]
ChEMBL Agonist potency against cloned Metabotropic glutamate receptor 8 (mGluR-8). F 6.68 pKi 210 nM Ki J Med Chem (2000) 43: 2609-2645 [PMID:10893301]
GtoPdb - - 6.7 pEC50 - - - J Pharmacol Exp Ther (1999) 289: 1678-1687 [PMID:10336568];
Bioorg Med Chem Lett (2000) 10: 1241-4 [PMID:10866390];
Neuropharmacology (2001) 40: 311-8 [PMID:11166323]
mGlu8 receptor/Metabotropic glutamate receptor 8 in Rat (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2718] [GtoPdb: 296] [UniProtKB: P70579]
ChEMBL Metabotropic glutamate receptor 8 agonist activity against forskolin stimulated c-AMP formation in rat non neuronal cells F 6.68 pEC50 210 nM EC50 J Med Chem (2004) 47: 456-466 [PMID:14711315]

ChEMBL data shown on this page come from version 32:

Mendez D, Gaulton A, Bento AP, Chambers J, De Veij M, Félix E, Magariños MP, Mosquera JF, Mutowo P, Nowotka M, Gordillo-Marañón M, Hunter F, Junco L, Mugumbate G, Rodriguez-Lopez M, Atkinson F, Bosc N, Radoux CJ, Segura-Cabrera A, Hersey A, Leach AR. (2019) 'ChEMBL: towards direct deposition of bioassay data' Nucleic Acids Res., 47(D1). DOI: 10.1093/nar/gky1075. [EPMCID:30398643]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]