ChEMBL ligand: CHEMBL625 (E233, Equizole, Lombristop, Mintezol, Minzolum, MK-360, Nemapan, NSC-525040, NSC-90507, Omnizole, Pitrizet, Thiabendazole, Thiabenzole, Tiabendazol, Tiabendazole)
CYP1A2/Cytochrome P450 1A2 in Human [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177] There should be some charts here, you may need to enable JavaScript!
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942] There should be some charts here, you may need to enable JavaScript!
histone deacetylase 6/Histone deacetylase 6 in Human [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7] There should be some charts here, you may need to enable JavaScript!
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 [ChEMBL: CHEMBL247] [UniProtKB: Q72547] There should be some charts here, you may need to enable JavaScript!
Methionine aminopeptidase in Escherichia coli [ChEMBL: CHEMBL3423] [UniProtKB: P0AE18] There should be some charts here, you may need to enable JavaScript!
Methionyl aminopeptidase 1/Methionine aminopeptidase 1 in Human [ChEMBL: CHEMBL2474] [GtoPdb: 1572] [UniProtKB: P53582] There should be some charts here, you may need to enable JavaScript!
Methionyl aminopeptidase 2/Methionine aminopeptidase 2 in Human [ChEMBL: CHEMBL3922] [GtoPdb: 1573] [UniProtKB: P50579] There should be some charts here, you may need to enable JavaScript!

DB	Assay description	Assay Type	Standard value	Standard parameter	Original value	Original units	Original parameter	Reference
CYP1A2/Cytochrome P450 1A2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3356] [GtoPdb: 1319] [UniProtKB: P05177]
ChEMBL	DRUGMATRIX: CYP450, 1A2 enzyme inhibition (substrate: 3-Cyano-7-ethoxycoumarin)	B	6.1	pIC50	800	nM	IC50	DrugMatrix in vitro pharmacology data
FKBP prolyl isomerase 1A/FK506-binding protein 1A in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1902] [GtoPdb: 2609] [UniProtKB: P62942]
ChEMBL	Binding affinity to human FKBP12 expressed in Escherichia coli BL21(DE3) by isothermal titration calorimetry	B	4.22	pKd	60000	nM	Kd	J Med Chem (2007) 50: 6607-6617 [PMID:18038971]
histone deacetylase 6/Histone deacetylase 6 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL1865] [GtoPdb: 2618] [UniProtKB: Q9UBN7]
ChEMBL	Determination of IC50 values for inhibition of enzymatic assay of human HDAC6 with custom peptide substrate	B	6.44	pIC50	362.9	nM	IC50	HDAC6 screening dataset using tau-based substrate in an enzymatic assay yields selective inhibitors and activators
Human immunodeficiency virus type 1 reverse transcriptase in Human immunodeficiency virus 1 (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL247] [UniProtKB: Q72547]
ChEMBL	HIV-1 reverse transcriptase (RT) activity using Poly (rC)/oligo (dG) as template/primer and [3H]dGTP	B	4.84	pIC50	14600	nM	IC50	J Med Chem (2002) 45: 5410-5413 [PMID:12431069]
Methionine aminopeptidase in Escherichia coli (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3423] [UniProtKB: P0AE18]
ChEMBL	Inhibition of Co2+ loaded MetAP expressed in Escherichia coli	B	6.33	pIC50	472	nM	IC50	J Med Chem (2006) 49: 511-522 [PMID:16420038]
Methionyl aminopeptidase 1/Methionine aminopeptidase 1 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL2474] [GtoPdb: 1572] [UniProtKB: P53582]
ChEMBL	Inhibition of human MetAP1	B	4.32	pIC50	47800	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4038-4044 [PMID:20621724]
ChEMBL	Inhibition of human methionine aminopeptidase 1 in presence of Mn2+	B	4	pEC50	>100000	nM	EC50	J Med Chem (2013) 56: 3996-4016 [PMID:23634668]
ChEMBL	Inhibition of human methionine aminopeptidase 1 in presence of Co2+	B	5.47	pEC50	3400	nM	EC50	J Med Chem (2013) 56: 3996-4016 [PMID:23634668]
Methionyl aminopeptidase 2/Methionine aminopeptidase 2 in Human (target type: SINGLE PROTEIN) [ChEMBL: CHEMBL3922] [GtoPdb: 1573] [UniProtKB: P50579]
ChEMBL	Inhibition of human MetAP2 expressed in baculovirus infected Sf9 cells	B	4.35	pIC50	44700	nM	IC50	Bioorg Med Chem Lett (2010) 20: 4038-4044 [PMID:20621724]

ChEMBL data shown on this page come from version 34:

Zdrazil B, Felix E, Hunter F, Manners EJ, Blackshaw J, Corbett S, de Veij M, Ioannidis H, Lopez DM, Mosquera JF, Magarinos MP, Bosc N, Arcila R, Kizilören T, Gaulton A, Bento AP, Adasme MF, Monecke P, Landrum GA, Leach AR. (2024). The ChEMBL Database in 2023: a drug discovery platform spanning multiple bioactivity data types and time periods. Nucleic Acids Res., 52(D1). DOI: 10.1093/nar/gkad1004. [EPMCID:10767899] [PMID:37933841]
Davies M, Nowotka M, Papadatos G, Dedman N, Gaulton A, Atkinson F, Bellis L, Overington JP. (2015) 'ChEMBL web services: streamlining access to drug discovery data and utilities.' Nucleic Acids Res., 43(W1). DOI: 10.1093/nar/gkv352. [EPMCID:25883136]