Methionyl aminopeptidase 1 | M24: Methionyl aminopeptidase | IUPHAR/BPS Guide to PHARMACOLOGY

Top ▲

Methionyl aminopeptidase 1

Target not currently curated in GtoImmuPdb

Target id: 1572

Nomenclature: Methionyl aminopeptidase 1

Family: M24: Methionyl aminopeptidase

Gene and Protein Information
Species TM AA Chromosomal Location Gene Symbol Gene Name Reference
Human - 386 4q23 METAP1 methionyl aminopeptidase 1
Mouse - 386 3 G3 Metap1 methionyl aminopeptidase 1
Rat - 386 2q44 Metap1 methionyl aminopeptidase 1
Previous and Unofficial Names
MAP1A | Peptidase M | methionine aminopeptidase 1 | MetAP1A
Database Links
Specialist databases
MEROPS M24.017 (Hs)
Other databases
ChEMBL Target
Ensembl Gene
Entrez Gene
Human Protein Atlas
KEGG Enzyme
RefSeq Nucleotide
RefSeq Protein
Enzyme Reaction
EC Number:
EC Number:

Download all structure-activity data for this target as a CSV file

Key to terms and symbols View all chemical structures Click column headers to sort
Ligand Sp. Action Value Parameter Reference
compound 14 [PMID: 23634668] Hs Inhibition 7.0 pEC50 1
pEC50 7.0 (EC50 9.3x10-8 M) [1]
Description: In the presence of Co.


Show »

1. Zhang F, Bhat S, Gabelli SB, Chen X, Miller MS, Nacev BA, Cheng YL, Meyers DJ, Tenney K, Shim JS et al.. (2013) Pyridinylquinazolines selectively inhibit human methionine aminopeptidase-1 in cells. J. Med. Chem., 56 (10): 3996-4016. [PMID:23634668]

How to cite this page

M24: Methionyl aminopeptidase: Methionyl aminopeptidase 1. Last modified on 14/07/2015. Accessed on 26/09/2020. IUPHAR/BPS Guide to PHARMACOLOGY,